All Phenotypes Ctnnb1<Bfc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctnnb1^Bfc/Ctnnb1^Bfc	either: (involves: BALB/cCrl * C3H/HeNCrl) or (involves: BALB/cCrl * C3H/HeNCrl * C57BL/6)	MGI:4947309
ht2	Ctnnb1^Bfc/Ctnnb1⁺	either: (involves: BALB/cCrl * C3H/HeNCrl) or (involves: BALB/cCrl * C3H/HeNCrl * C57BL/6)	MGI:4947308
ht3	Ctnnb1^Bfc/Ctnnb1⁺	involves: BALB/cCrl * C3H/HeNCrl	MGI:2656754
cx4	Ctnnb1^Bfc/Ctnnb1⁺ Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6⁺	either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)	MGI:4947311
cx5	Ctnnb1^Bfc/Ctnnb1⁺ Lrp6^Gw/Lrp6⁺	either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6)	MGI:4947310
cx6	Ctnnb1^Bfc/Ctnnb1⁺ Dkk1^tm1Lmgd/Dkk1⁺	either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)	MGI:4947312
cx7	Ctnnb1^Bfc/Ctnnb1^Bfc Dkk1^tm1Lmgd/Dkk1⁺	either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)	MGI:4947313

Allelic Composition	Ctnnb1^Bfc/Ctnnb1^Bfc
Genetic Background	either: (involves: BALB/cCrl * C3H/HeNCrl) or (involves: BALB/cCrl * C3H/HeNCrl * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^Bfc mutation (4 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:170646 )

• no viable mice are generated

growth/size/body

abnormal head size ( J:170646 )

• all mice exhibit head reduction defects unlike wild-type mice

Allelic Composition	Ctnnb1^Bfc/Ctnnb1⁺
Genetic Background	either: (involves: BALB/cCrl * C3H/HeNCrl) or (involves: BALB/cCrl * C3H/HeNCrl * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^Bfc mutation (4 available); any Ctnnb1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:170646 )

• fewer than expected mice are produced

vision/eye

abnormal eye morphology ( J:170646 )

• mice exhibit ocular defects that are more prominent on a background with C57BL/6 compared with BALB/c

cataract ( J:170646 )

• mice exhibit cataract-like lens opacity unlike wild-type mice

microphthalmia ( J:170646 )

anophthalmia ( J:170646 )

nervous system

forebrain hypoplasia ( J:170646 )

• 38% of mice at E8-9.0 and 90% of mice at E9-10 exhibit head defects with reduced forebrain unlike wild-type mice

craniofacial

flattened snout ( J:170646 )

• squashed snout

growth/size/body

abnormal head morphology ( J:170646 )

• 38% of mice at E8-9.0 and 90% of mice at E9-10 exhibit head defects with reduced forebrain unlike wild-type mice

• 23% of mice exhibit reduced head tissue compared with wild-type mice

• at E9.0 to E10.0, 27% of mice exhibit head defects compared with 2% of wild-type mice

flattened snout ( J:170646 )

• squashed snout

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

broad head ( J:63816 , J:209611 )

• broad face (J:63816)

• the anteroposterior axis was significantly shortened, whereas the dorsoventral and medial-lateral axes were enlarged (J:209611)

vision/eye

ocular hypertelorism ( J:63816 )

• wide-spaced eyes

growth/size/body

broad head ( J:63816 , J:209611 )

• broad face (J:63816)

• the anteroposterior axis was significantly shortened, whereas the dorsoventral and medial-lateral axes were enlarged (J:209611)

nervous system

increased brain size ( J:209611 )

• gray matter and total brain volumes were significantly larger in Bfc/+ (P < 0.05; 1-way ANOVA)

decreased corpus callosum size ( J:209611 )

• the corpus callosum appeared to be severely underdeveloped in 3 Bfc/+ individuals, and lacked any inter-hemispheric extensions

abnormal globus pallidus morphology ( J:209611 )

• globus pallidus is slightly, but significantly, larger in Bfc/+

increased striatum size ( J:209611 )

• striatum is slightly, but significantly, larger in Bfc/+

enlarged thalamus ( J:209611 )

• thalamus is slightly, but significantly, larger in Bfc/+

abnormal hippocampus neuron morphology ( J:209611 )

• the length and number of neurites were significantly increased after only 1 day in culture

• after 8 days in culture, the extent of dendritic branching in heterozygous neurons was dramatically lower than in controls

small olfactory bulb ( J:209611 )

• mutants showed substantially reduced cerebellar and olfactory bulb volumes compared with controls

small cerebellum ( J:209611 )

• mutants showed substantially reduced cerebellar and olfactory bulb volumes compared with controls

abnormal synaptic vesicle clustering ( J:209611 )

• heterozygotes, a lower density of docked synaptic vesicles (SV) in cortex and in hippocampus CA1 region is seen

reduced long-term potentiation ( J:209611 )

• long-term potentiation (LTP) induced by either tetanic or theta-burst stimulation was significantly reduced in hippocampus CA1 slices from heterozygous mice

decreased prepulse inhibition ( J:209611 )

• heterozygous mice mice show significant PPI deficits but acoustic startle response is comparable to controls

behavior/neurological

impaired contextual conditioning behavior ( J:209611 )

• freezing behavior in heterozygous mice using a standard fear conditioning protocol for contextual memory is significantly lower than that of littermate controls, suggesting that mutants have a reduced capacity to recall the previous shock exposure

abnormal operant conditioning behavior ( J:209611 )

• for trials in which rewards are given after a light event, responses increase significantly during the expected time interval in control mice, but not in heterozygous mutants

• in probe trials where no reward is given, responses of heterozygous mutant mice during the critical time window is significantly lower than littermate controls

abnormal spatial reference memory ( J:209611 )

• control animals improve performance with repeated trials in the hidden platform variation of the water maze test, but heterozygous mutant mice did not improve

impaired coordination ( J:209611 )

• heterozygous mice show a significantly shorter latency period before falling from the rod in a challenging rotarod test incorporaing 6 consecutive accelerating stages in a single session; no differences are seen in a standard rotarod test

abnormal vocalization ( J:209611 )

• heterozygous pups exhibit a significant reduction in the total number of vocalizations with more of these calls characterized by a single component compared to controls

Allelic Composition	Ctnnb1^Bfc/Ctnnb1⁺ Dkk1^tm1Lmgd/Dkk1⁺ Lrp6^Gw/Lrp6⁺
Genetic Background	either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^Bfc mutation (4 available); any Ctnnb1 mutation (49 available)
Dkk1^tm1Lmgd mutation (0 available); any Dkk1 mutation (17 available)
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

caudal body truncation ( J:170646 )

• 23% of mice exhibit complete head truncation unlike wild-type mice

growth/size/body

abnormal head size ( J:170646 )

• all mice exhibit head reduction defects unlike wild-type mice

Allelic Composition	Ctnnb1^Bfc/Ctnnb1⁺ Lrp6^Gw/Lrp6⁺
Genetic Background	either: (involves: 101/H * BALB/cCrl * C3H) or (involves: 101/H * BALB/cCrl * C3H * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^Bfc mutation (4 available); any Ctnnb1 mutation (49 available)
Lrp6^Gw mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal head size ( J:170646 )

• 86% of mice exhibit head reduction defects unlike wild-type mice

Allelic Composition	Ctnnb1^Bfc/Ctnnb1⁺ Dkk1^tm1Lmgd/Dkk1⁺
Genetic Background	either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:170646 )

• fewer than expected mice are produced

• viability is less than in Ctnnb1^Bfc heterozygotes

vision/eye

abnormal eye morphology ( J:170646 )

• ocular defects are higher than in Ctnnb1^Bfc heterozygotes

growth/size/body

abnormal head morphology ( J:170646 )

• 92% of mice exhibit head defects compared with wild-type mice

• head defects are higher than in Ctnnb1^Bfc heterozygotes

Allelic Composition	Ctnnb1^Bfc/Ctnnb1^Bfc Dkk1^tm1Lmgd/Dkk1⁺
Genetic Background	either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal head size ( J:170646 )

• all mice exhibit head reduction defects unlike wild-type mice

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