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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Edil3Tg(Sox2-cre)1Amc
transgene insertion 1, Andrew P McMahon
MGI:2656539
Summary 111 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cul4btm1Swl/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
B6.Cg-Edil3Tg(Sox2-cre)1Amc Cul4btm1Swl MGI:5438241
cn2
Prkag2tm1.1Geno/Prkag2tm1.1Geno
Edil3Tg(Sox2-cre)1Amc/Edil3+
B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc MGI:6116214
cn3
Abcb7tm1Mdf/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: B6.Cg-Edil3Tg(Sox2-cre)1Amc Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA) MGI:3629061
cn4
Abcb7tm1Mdf/Abcb7+
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: B6.Cg-Edil3Tg(Sox2-cre)1Amc Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA) MGI:3629062
cn5
Kdm6atm1c(EUCOMM)Wtsi/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1) MGI:5516067
cn6
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1) MGI:5516066
cn7
Cul4btm1.1Pz/Cul4b+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:5502173
cn8
Fnip1m1Btlr/Fnip1m1Btlr
Prkag2tm1.1Geno/Prkag2tm1.1Geno
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:6116217
cn9
Cul4btm1.1Pz/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:5502172
cn10
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA MGI:4412194
cn11
Dicer1tm1Bdh/Dicer1tm1Bdh
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA MGI:6156399
cn12
Ddx3xtm1.1Lyou/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA MGI:5774972
cn13
Ddx3xtm1.1Lyou/Ddx3x+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA MGI:5774973
cn14
Lrp5tm1Kry/Lrp5tm1Kry
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA MGI:4412197
cn15
Fzd4tm1Nat/Fzd4tm1Nat
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA MGI:4412196
cn16
Fzd4tm1Nat/Fzd4+
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
involves: 129 * C57BL/6 * CBA MGI:4412195
cn17
Cited2tm1Bha/Cited2tm2Bha
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129 * C57BL/6 * CBA * SJL MGI:3804085
cn18
Cdx2tm1Fbe/Cdx2tm2Fbe
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA MGI:5308975
cn19
Zfp568Gt(P103E09)Wrst/Zfp568Gt(RRU161)Byg
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA MGI:4882136
cn20
Arap3tm1.1Sve/Arap3tm1.2Sve
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL MGI:5428759
cn21
Casz1tm1.1Flc/Casz1tm1.1Flc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL MGI:5811819
cn22
Mapk11tm1Jsca/Mapk11+
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5461498
cn23
Map2k1tm1Bacc/Map2k1tm1.1Bacc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5504406
cn24
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5288510
cn25
Myctm2.1Atp/Myctm2.1Atp
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3811915
cn26
Elavl1tm1Dkon/Elavl1tm1Dkon
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3847920
cn27
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5288513
cn28
Chd1tm1c(KOMP)Rsan/Chd1tm1c(KOMP)Rsan
Edil3Tg(Sox2-cre)1Amc/?
involves: 129P2/OlaHsd * C57BL/6J * CBA MGI:5708149
cn29
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA MGI:5440178
cn30
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA MGI:5440177
cn31
Lama1tm1.1Arhi/Lama1tm1.2Arhi
Edil3Tg(Sox2-cre)1Amc/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5426832
cn32
Dph1tm1.1Cmch/Dph1tm1.1Cmch
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA MGI:5659970
cn33
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5544091
cn34
Shhtm2Chg/Shh+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3687544
cn35
Porcntm1.1Lcm/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5049886
cn36
Porcntm1.1Lcm/Porcn+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5049887
cn37
Disp1tm1Pab/Disp1tm1Pab
Shhtm2Chg/Shh+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3687546
cn38
Shhtm1Chg/Shhtm2Chg
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3687543
cn39
Edil3Tg(Sox2-cre)1Amc/Edil3+
Wnt7atm1Amc/Wnt7atm1Amc
Wnt7btm1Parr/Wnt7btm2Amc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3831189
cn40
Sall4tm2Tre/Sall4tm2.1Tre
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * CD-1 MGI:3693081
cn41
Fzd5tm1Nat/Fzd5tm2Nat
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL MGI:3807221
cn42
Dag1tm1Kcam/Dag1tm2.1Kcam
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5470527
cn43
Pnkptm1.1Pmc/Pnkptm1.1Pmc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * C57BL/6 * CBA MGI:5795747
cn44
Trim28tm1.1Ipc/Trim28tm1.2Ipc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6 * CBA MGI:5620619
cn45
Pak4tm2.1Amin/Pak4tm2.2Amin
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N MGI:4360349
cn46
Trim33tm1.1Los/Trim33tm1.2Los
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6 * CBA * SJL MGI:4830326
cn47
Lama1tm1Olf/Lama1tm1Olf
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster MGI:4456114
cn48
Rac1tm1Tyb/Rac1tm2Tyb
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C3H * C57BL/6 * CBA MGI:5050115
cn49
Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5140923
cn50
Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5140925
cn51
Trpm7tm1Clph/Trpm7tm1.1Clph
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3814711
cn52
Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA MGI:5470168
cn53
Dab2tm2.1Xxx/Dab2tm2.2Xxx
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:5562566
cn54
Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:5140926
cn55
Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S5/SvEvBrd * C57BL/6 * CBA MGI:4360982
cn56
Gli3tm1Alj/Gli3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA MGI:5791934
cn57
Nsdhltm1.1Hrm/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA MGI:5896533
cn58
Nsdhltm1.1Hrm/Nsdhl+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA MGI:5896532
cn59
Gt(ROSA)26Sortm10(Gata2)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470273
cn60
Gt(ROSA)26Sortm8(Aifm1)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470271
cn61
Gt(ROSA)26Sortm6(Vegfa*)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470268
cn62
Gt(ROSA)26Sortm16Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5502197
cn63
Gt(ROSA)26Sortm5(CAG-Mdm4,-EGFP)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470266
cn64
Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470265
cn65
Gt(ROSA)26Sortm4(Snai1)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470264
cn66
Gt(ROSA)26Sortm11(Gata3)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470274
cn67
Gt(ROSA)26Sortm9(Aifm1*)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470272
cn68
Gt(ROSA)26Sortm14Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5470277
cn69
Eef1a1tm1Tcrl/Eef1a1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5692456
cn70
Fam20ctm1.1Cqi/Fam20ctm1.1Cqi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5428021
cn71
Psip1tm1Eng/Psip1tm1Eng
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5294952
cn72
Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:4360361
cn73
Ubr4tm1.2Nkt/Ubr4tm1.2Nkt
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:5532401
cn74
Esrrbtm1.1Nat/Esrrbtm1.2Nat
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:3723508
cn75
E2f7tm1Gle/E2f7tm1Gle
E2f8tm1Gle/E2f8tm1Gle
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5473267
cn76
Ptentm1Ppp/Pten+
Rac1tm1Tyb/Rac1tm2Tyb
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/Sv * C3H * C57BL/6 * CBA MGI:5050118
cn77
Eomestm1Rob/Eomestm1.1Rob
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA MGI:3775735
cn78
Tlk2tm1.1Strc/Tlk2tm1.2Strc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C3H * C57BL/6 MGI:6274368
cn79
Nodaltm1Rob/Nodaltm5Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 MGI:3056367
cn80
Nodaltm1Rob/Nodal+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA MGI:4437426
cn81
Edil3Tg(Sox2-cre)1Amc/Edil3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA MGI:4437424
cn82
Lhx1tm1Bhr/Lhx1tm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * C57BL/6N * CBA MGI:5699420
cn83
Eomestm1Rob/Eomestm1.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA MGI:3775733
cn84
Eomestm1Rob/Eomes+
Nodaltm1Rob/Nodal+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA MGI:3775737
cn85
Eomestm1Rob/Eomestm2.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA MGI:4399139
cn86
Smad2tm1Rob/Smad2tm2Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * C57BL/6 * CBA * CD-1 MGI:2668417
cn87
Map2k1tm1Chrn/Map2k1tm1.1Chrn
Edil3Tg(Sox2-cre)1Amc/?
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N MGI:3714923
cn88
Smad4tm1Rob/Smad4tm1.1Rob
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * CD-1 MGI:3624716
cn89
Smad2tm1Rob/Smad2tm2Rob
Smad3tm1Xfw/Smad3+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129/Sv * 129S/SvEv * C57BL/6 * CBA * CD-1 MGI:3689505
cn90
Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129/Sv * C57BL/6J * SWR MGI:3513053
cn91
Wnt7btm2Amc/Wnt7btm2.1Amc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129X1/SvJ * C57BL/6 * CBA MGI:3793499
cn92
Fzr1tm1Mama/Fzr1tm1.1Mama
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: BALB/cJ * C57BL/6 * SJL MGI:3801167
cn93
Nuggctm1Diaz/Nuggctm1Diaz
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * C57BL/6J * CBA MGI:5476766
cn94
Ctsdtm1.1Thre/Ctsdtm1.1Thre
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * C57BL/6N * CBA * SJL MGI:5702327
cn95
Prickle1tm1.3Asw/Prickle1tm1.3Asw
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:5649031
cn96
Prickle1tm1.2Asw/Prickle1tm1.3Asw
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:5649032
cn97
Hcfc1tm1Lwh/Hcfc1tm1Lwh
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:5901762
cn98
Hcfc1tm1Lwh/Hcfc1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:5901761
cn99
Zic3tm1.1Smwa/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:5476839
cn100
Hcfc1tm1Lwh/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:5901759
cn101
Slc13a4tm1c(EUCOMM)Wtsi/Slc13a4tm1d(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:5896626
cn102
Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:5288515
cn103
Enpp2tm1Vart/Enpp2tm1Vart
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA MGI:4441466
cn104
Fzr1tm1Mama/Fzr1tm1Mama
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6 * CBA * SJL MGI:3801166
cn105
Foxp2tm1Sfis/Foxp2tm1.2Sfis
Edil3Tg(Sox2-cre)1Amc/?
involves: C57BL/6 * CBA * SJL MGI:3723632
cn106
Prdm15tm1c(EUCOMM)Wtsi/Prdm15tm1c(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6J * C57BL/6N MGI:6403992
cn107
Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL/6N MGI:5796348
cn108
Edil3Tg(Sox2-cre)1Amc/Edil3+
Strip1tm1b(KOMP)Wtsi/Strip1tm1c(KOMP)Wtsi
involves: C57BL/6N * CBA * FVB/NJ * SJL MGI:6121353
cn109
Vps52tm1.1Kab/Vps52tm1.2Kab
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: C57BL * C57BL/6 * CBA * DBA MGI:5464113
cx110
Evc2tm2.1Mis/Evc2tm2.1Mis
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129X1/SvJ * C57BL/6 * CBA MGI:5698047
cx111
Edil3Tg(Sox2-cre)1Amc/0
Gt(ROSA)26Sortm1.1(DUX4*)Plj/Gt(ROSA)26Sor+
involves: C57BL/6 * CBA MGI:6120561


Genotype
MGI:5438241
cn1
Allelic
Composition
Cul4btm1Swl/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
B6.Cg-Edil3Tg(Sox2-cre)1Amc Cul4btm1Swl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4btm1Swl mutation (0 available); any Cul4b mutation (29 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• hippocampal neurons exhibit reduced dendritic complexity and spine density compared with control neurons
• hippocampal neurons exhibit reduced dendritic complexity and spine density compared with control neurons
• fewer PV+ hippocampal neurons
• however, mice exhibit normal numbers of SS+ and GAD67+ neurons

behavior/neurological
• impaired in a Morris water maze
• impaired in a Morris water maze

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
intellectual disability DOID:1059 J:187403




Genotype
MGI:6116214
cn2
Allelic
Composition
Prkag2tm1.1Geno/Prkag2tm1.1Geno
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Prkag2tm1.1Geno mutation (0 available); any Prkag2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• small but significant increase in heart rate, both in vivo under anesthesia and during ambulatory telemetric recordings, as well as in ex vivo
• sinoatrial cells display enhanced automaticity but equivalent maximum diastolic potential and cell capacitance to controls
• however, sinoatrial cells show normal sarcolemmal hyperpolarization-activated funny current, I(f) density and no changes in fractional activation
• sinoatrial cells reach a similar maximal rate in response to isoproterenol as controls, but starting from a higher baseline rate, this reflects a smaller proportional increase from baseline




Genotype
MGI:3629061
cn3
Allelic
Composition
Abcb7tm1Mdf/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
either: B6.Cg-Edil3Tg(Sox2-cre)1Amc Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb7tm1Mdf mutation (1 available); any Abcb7 mutation (6 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3629062
cn4
Allelic
Composition
Abcb7tm1Mdf/Abcb7+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
either: B6.Cg-Edil3Tg(Sox2-cre)1Amc Abcb7tm1Mdf or (involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcb7tm1Mdf mutation (1 available); any Abcb7 mutation (6 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• females are viable




Genotype
MGI:5516067
cn5
Allelic
Composition
Kdm6atm1c(EUCOMM)Wtsi/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• males recovered at expected frequencies at E18.5




Genotype
MGI:5516066
cn6
Allelic
Composition
Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Kdm6atm1c(EUCOMM)Wtsi mutation (1 available); any Kdm6a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5502173
cn7
Allelic
Composition
Cul4btm1.1Pz/Cul4b+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4btm1.1Pz mutation (0 available); any Cul4b mutation (29 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• live mice are produced in Mendelian ratios




Genotype
MGI:6116217
cn8
Allelic
Composition
Fnip1m1Btlr/Fnip1m1Btlr
Prkag2tm1.1Geno/Prkag2tm1.1Geno
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Fnip1m1Btlr mutation (0 available); any Fnip1 mutation (39 available)
Prkag2tm1.1Geno mutation (0 available); any Prkag2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit rescue of the bradycardia seen in single Fnip1 homozygotes




Genotype
MGI:5502172
cn9
Allelic
Composition
Cul4btm1.1Pz/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4btm1.1Pz mutation (0 available); any Cul4b mutation (29 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are healthy and show no abnormal development




Genotype
MGI:4412194
cn10
Allelic
Composition
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mid-gestational lethality

growth/size/body
• Background Sensitivity: growth retardation at E10.5

cardiovascular system
• Background Sensitivity: no visceral smooth muscle associated with the aorta at E9.5
• Background Sensitivity: severely disrupted

embryo
• Background Sensitivity: growth retardation at E10.5

muscle
• Background Sensitivity: no visceral smooth muscle associated with the aorta at E9.5




Genotype
MGI:6156399
cn11
Allelic
Composition
Dicer1tm1Bdh/Dicer1tm1Bdh
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Bdh mutation (4 available); any Dicer1 mutation (62 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• observed at E8.5

nervous system
• observed at E8.5




Genotype
MGI:5774972
cn12
Allelic
Composition
Ddx3xtm1.1Lyou/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx3xtm1.1Lyou mutation (0 available); any Ddx3x mutation (8 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• non-viable embryos are detected at E10.5 and E11.5
• by weaning no males are detected

embryo
• in the whole body and allantois before embryo turning
• deformed caudal embryonic structure at E9.5
• failure of body turning
• developmental delay at E9.5
• shorter at E9.5
• at E8.5 in unturned embryos

cellular
• increase in markers of DNA damage
• cell cycle arrest
• in embryos at E9.5
• in the whole body and allantois before embryo turning

cardiovascular system

growth/size/body
• developmental delay at E9.5

nervous system
• underdeveloped

homeostasis/metabolism

muscle




Genotype
MGI:5774973
cn13
Allelic
Composition
Ddx3xtm1.1Lyou/Ddx3x+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx3xtm1.1Lyou mutation (0 available); any Ddx3x mutation (8 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• females with loss of expression of the maternal allele in the epiblast but not visceral endoderm and extraembryonic ectoderm are viable with no gross abnormalities




Genotype
MGI:4412197
cn14
Allelic
Composition
Lrp5tm1Kry/Lrp5tm1Kry
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
Lrp5tm1Kry mutation (0 available); any Lrp5 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mid-gestational lethality but some survival improvement

growth/size/body
• Background Sensitivity: growth retardation moderated

cardiovascular system
• Background Sensitivity: disruption less severe
• Background Sensitivity: less severely disrupted

embryo
• Background Sensitivity: growth retardation moderated




Genotype
MGI:4412196
cn15
Allelic
Composition
Fzd4tm1Nat/Fzd4tm1Nat
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (18 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• Background Sensitivity: normal survival

growth/size/body
N
• Background Sensitivity: normal phenotype

cardiovascular system
N
• Background Sensitivity: normal phenotype




Genotype
MGI:4412195
cn16
Allelic
Composition
Fzd4tm1Nat/Fzd4+
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat/Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Fzd4tm1Nat mutation (1 available); any Fzd4 mutation (18 available)
Igs1tm2(CAG-Bgeo,-Ndp,-EGFP)Nat mutation (1 available); any Igs1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mid-gestational lethality but some survival to E18

growth/size/body
• Background Sensitivity: growth retardation moderated

cardiovascular system
• Background Sensitivity: disruption less severe
• Background Sensitivity: less severely disrupted

embryo
• Background Sensitivity: growth retardation moderated




Genotype
MGI:3804085
cn17
Allelic
Composition
Cited2tm1Bha/Cited2tm2Bha
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (4 available); any Cited2 mutation (14 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (14 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• though present in Mendelian ratios at E15.5, mice die during late gestation or postnatal development with no mice present at weaning
• though present in Mendelian ratios at E15.5, mice die during late gestation or postnatal development with no mice present at weaning

cardiovascular system
• in some mice
• bilateral in one mouse
• some mice exhibit a common atrioventricular valve
• in some mice
• in one mouse
• in all embryos at E15.5
• abnormal ventricular topology

respiratory system
• in 6 of 10 embryos and associated with right atrial isomerism at E15.5

nervous system
• 2 mice at E15.5

endocrine/exocrine glands

growth/size/body
• in some mice
• in 6 of 10 embryos and associated with right atrial isomerism at E15.5




Genotype
MGI:5308975
cn18
Allelic
Composition
Cdx2tm1Fbe/Cdx2tm2Fbe
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx2tm1Fbe mutation (0 available); any Cdx2 mutation (17 available)
Cdx2tm2Fbe mutation (0 available); any Cdx2 mutation (17 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo




Genotype
MGI:4882136
cn19
Allelic
Composition
Zfp568Gt(P103E09)Wrst/Zfp568Gt(RRU161)Byg
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Zfp568Gt(P103E09)Wrst mutation (0 available); any Zfp568 mutation (100 available)
Zfp568Gt(RRU161)Byg mutation (0 available); any Zfp568 mutation (100 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• partial rescue of the null phenotype with some embryos displaying all defects seen in mice homozygous for Zfp568chato, some displaying only the extraembryonic defects, and some having a wild-type phenotype
• the degree of rescue is at least partially related to the degree of cre mediated recombination




Genotype
MGI:5428759
cn20
Allelic
Composition
Arap3tm1.1Sve/Arap3tm1.2Sve
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arap3tm1.1Sve mutation (0 available); any Arap3 mutation (0 available)
Arap3tm1.2Sve mutation (0 available); any Arap3 mutation (0 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die around E11
• identical to mice homozygous for Arap3tm1.2Sve

embryo
• identical to mice homozygous for Arap3tm1.2Sve
• defect in labyrinth formation

cardiovascular system
• identical to mice homozygous for Arap3tm1.2Sve

growth/size/body

integument




Genotype
MGI:5811819
cn21
Allelic
Composition
Casz1tm1.1Flc/Casz1tm1.1Flc
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casz1tm1.1Flc mutation (1 available); any Casz1 mutation (283 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• at E12.5, embryos show a cardiac phenotype indistinguishable from that of embryos homozygous for Casz1tm1.1Flc and heterozygous for Nkx2-5tm1(cre)Rjs
• severe cardiac hypoplasia at E12.5




Genotype
MGI:5461498
cn22
Allelic
Composition
Mapk11tm1Jsca/Mapk11+
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (26 available)
Mapk14tm2Nbr mutation (2 available); any Mapk14 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• XY sex reversal of gonads at E14.5




Genotype
MGI:5504406
cn23
Allelic
Composition
Map2k1tm1Bacc/Map2k1tm1.1Bacc
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Map2k1tm1.1Bacc mutation (0 available); any Map2k1 mutation (94 available)
Map2k1tm1Bacc mutation (0 available); any Map2k1 mutation (94 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice do not exhibit any obvious phenotypes




Genotype
MGI:5288510
cn24
Allelic
Composition
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (26 available)
Mapk14tm2Nbr mutation (2 available); any Mapk14 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Developmental defects in Mapk14tm2Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 Mapk11tm1Jsca/Mapk11tm1Jsca embryos

mortality/aging

nervous system
• spina bifida is correlated with neural hyperproliferation
• at E13.5
• in 30% of mice at E13.5

cardiovascular system
• decreased proliferation at E13.5

liver/biliary system
• at E13.5 dissociated hepatocytes and infiltration of hematopoietic cells are seen
• at E13.5

reproductive system
• complete XY sex reversal of gonads at E14.5

muscle
• decreased proliferation at E13.5

embryo
• at E13.5

cellular
• decreased proliferation at E13.5
• spina bifida is correlated with neural hyperproliferation




Genotype
MGI:3811915
cn25
Allelic
Composition
Myctm2.1Atp/Myctm2.1Atp
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Myctm2.1Atp mutation (0 available); any Myc mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

liver/biliary system

hematopoietic system
• when embryonic or yolk sac cells are cultured, few abnormal colony-forming unit-granulocyte/macrophage colonies form unlike when wild-type cells are cultured
• despite normal numbers of hematopoietic stem cells, hematopoiesis is impaired
• erythroblast precursors are decreased 1500-fold compared to in wild-type mice due to a 19-fold increased in apoptosis at E9.5 and a 41-fold increased at E10.5
• when embryonic or yolk sac cells are cultured, few abnormal blast-forming unit-erythroid colonies form unlike when wild-type cells are cultured
• the number of early basophilic erythroblasts is decreased 11.5-fold compared to in wild-type mice

embryo

growth/size/body

cardiovascular system
N
• embryonic vasculature development is normal




Genotype
MGI:3847920
cn26
Allelic
Composition
Elavl1tm1Dkon/Elavl1tm1Dkon
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Elavl1tm1Dkon mutation (1 available); any Elavl1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mid-gestational embryonic lethality is not observed in the offspring of male Tg(Sox2-cre)1Amc transgenics and female Elavl1tm1.1Dkon homozygotes
• instead fetuses die between E17.5 and E19.5

embryo
• E14.5 embryos possess limbs of reduced size, which in many cases lacked definable digits and resemble E12.5 limb buds

skeleton
• craniofacial osteogenic ossification is delayed in 80% of E17.5 embryos with the exception of mandibles that develop normally
• sternums in E17.5-E18.5 embryos have a xiphoid process that is open and bifid
• vertebrae are not ossified in E18.5 embryos and lack the articular processes that connect vertebrae
• radial and ulnar bones are fused in more than 40% of the E17.5 embryos
• skeletal structures of E17.5- E19.5 embryos remained primarily cartilaginous
• long bones are shorter in null embryos and show minimal ossification zones in scapulae, femurs, and tibia

craniofacial
• craniofacial osteogenic ossification is delayed in 80% of E17.5 embryos with the exception of mandibles that develop normally
• less than 15% of E17.5 embryos have severe nasal clefting

immune system
• spleens are absent in E15.5 and E19.5 embryos
• spleens are absent in E15.5 and E19.5 embryos

limbs/digits/tail
• E14.5 embryos possess limbs of reduced size, which in many cases lacked definable digits and resemble E12.5 limb buds
• is observed within both forelimbs (carpal to metacarpal) and hindlimbs (tarsal to metatarsal) of E17.5 embryos
• fetal mice have short limbs
• long bones are shorter in null embryos and show minimal ossification zones in the femurs and tibia

respiratory system
• major dysmorphologies occur in the lung of E19.5 embyros

hematopoietic system
• spleens are absent in E15.5 and E19.5 embryos
• spleens are absent in E15.5 and E19.5 embryos

growth/size/body
• less than 15% of E17.5 embryos have severe nasal clefting




Genotype
MGI:5288513
cn27
Allelic
Composition
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (26 available)
Mapk14tm2Nbr mutation (2 available); any Mapk14 mutation (31 available)
Mapk14tm3.1(Mapk11)Nbr mutation (0 available); any Mapk14 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cardiac defects in Mapk14tm3.1(Mapk11)Nbr/Mapk14tm2Nbr Edil3Tg(Sox2-cre)1Amc/0 Mapk11tm1Jsca/Mapk11tm1Jsca embryos

mortality/aging
• present in the expected numbers at E18.5 but none are found at weaning

cardiovascular system

nervous system
N
• spina bifida phenotype seen in double null mice is rescued in mice carrying the Mapk14tm3.1(Mapk11)Nbr allele




Genotype
MGI:5708149
cn28
Allelic
Composition
Chd1tm1c(KOMP)Rsan/Chd1tm1c(KOMP)Rsan
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd1tm1c(KOMP)Rsan mutation (1 available); any Chd1 mutation (15 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos undergoing resorption by E9.5




Genotype
MGI:5440178
cn29
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (23 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (23 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• absence of embryonic structures at E8.5




Genotype
MGI:5440177
cn30
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (23 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (23 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm1.1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E8.5 embryos have a sac-like structure composed of 2 layers where the outer layer is reminiscent of the visceral endoderm and the inner layer has characteristics of a pseudostratified epithelium
• expression analysis indicates failure to gastrulate
• formation of proper embryonic structures is incomplete




Genotype
MGI:5426832
cn31
Allelic
Composition
Lama1tm1.1Arhi/Lama1tm1.2Arhi
Edil3Tg(Sox2-cre)1Amc/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Lama1tm1.1Arhi mutation (0 available); any Lama1 mutation (6 available)
Lama1tm1.2Arhi mutation (0 available); any Lama1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice complete gestation and survive postnatally

behavior/neurological
• shorter latency to fall in a rotarod test

nervous system
• decreased depth of folia
• aggregations of granule cells on cerebellar surface along the line of fusion between adjacent folia
• Purkinje cell layer is distorted
• some Purkinje cells are not located in Purkinje cell layer
• fibers are short with fragmented endfeet
• dendritic tree of Purkinje cells is reduced
• fewer proliferating granule cell precursors from birth to 10 days of age
• migration of granule cells from external to internal layer is not observed
• superior colliculus is exposed on the surface of the brain
• pial basement membrane is irregular
• density of glial cells is reduced

cellular




Genotype
MGI:5659970
cn32
Allelic
Composition
Dph1tm1.1Cmch/Dph1tm1.1Cmch
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dph1tm1.1Cmch mutation (0 available); any Dph1 mutation (20 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die shortly after birth

craniofacial
• underdeveloped mandible
• in newborns
• in newborns
• palatal shelves remain in a vertical position
• tongue fails to descend

growth/size/body
• palatal shelves remain in a vertical position
• tongue fails to descend
• growth retardation at E14.5

homeostasis/metabolism

integument
• pale appearance at E14.5

digestive/alimentary system
• palatal shelves remain in a vertical position
• tongue fails to descend

skeleton
• underdeveloped mandible
• in newborns
• in newborns

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Miller-Dieker lissencephaly syndrome DOID:0060469 OMIM:247200
J:214744




Genotype
MGI:5544091
cn33
Allelic
Composition
Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Igs1tm11(CAG-Bgeo,-Edn2)Nat mutation (1 available); any Igs1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Inhibition of vascular development and midgestational lethality in Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Edil3Tg(Sox2-cre)1Amc/0 embryos

mortality/aging

cardiovascular system
• near complete absence of vascular development at E9.5
• at E9.5-E10.5
• pooling of blood in the head and thorax at E9.5-E10.5

embryo
• mild growth retardation at E8.5 and severe retardation at E9.5-E10.5
• at E9.5-E10.5

growth/size/body
• at E9.5-E10.5
• mild growth retardation at E8.5 and severe retardation at E9.5-E10.5

nervous system
• at E9.5-E10.5




Genotype
MGI:3687544
cn34
Allelic
Composition
Shhtm2Chg/Shh+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Shhtm2Chg mutation (0 available); any Shh mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals die perinatally

nervous system
• brain defects mimic human holoprosencephaly but external craniofacial morphology is relatively unaffected
• enlarged midbrain
• ventricles are enlarged at E10.5
• development is defective at E13.5
• telencephalic ventricles are widely separated at E10.5
• at E12.5, telencephalon lacks thickened hippocampal neuroepithelium
• at E10.5 dorsal midline has failed to invaginate in contrast to wild-type
• defective at E13.5
• apoptotic activity is eliminated in dorsal midline of telencephalon in contrast to wild-type at E9.5; apoptosis is 7-fold lower than in wild-type
• at E10, proliferation in roof plate region is similar to adjacent tissues and higher than seen in wild-type whereas proliferation is differentially reduced in wild-type embryo roof plate region
• dorsal midline is severely hypoplastic and lacks conjunction of corpus callosum and septum
• increased proliferation and decreased apoptosis persists at E10.5
• telencephalon lacks middle anterior commissure and characteristic choroid plexuses and hippocampal structures that are seen in wild-type; telencephalon lacks well-formed U-shaped hippocampus and ventricles are separated by enlarged thalamus
• frequent agenesis of dorsal corpus callosum is seen
• mutants lack olfactory bulbs
• a third eminence in addition to LGE and MGE is observed in mutants at E12.5
• eminence is expanded at expense of cortical domain of telencephalon
• eminence is expanded at expense of cortical domain of telencephalon

craniofacial
• many embryos display bulging cranium
• the maxillary shelves are not fully mineralized in the mutant
• mutants have cleft secondary palate
• palatal shelves fail to fuse; at E15.5, skeletal staining further shows the presence of widely separated palatal shelves

digestive/alimentary system
• the maxillary shelves are not fully mineralized in the mutant
• mutants have cleft secondary palate
• palatal shelves fail to fuse; at E15.5, skeletal staining further shows the presence of widely separated palatal shelves

skeleton
• many embryos display bulging cranium
• the maxillary shelves are not fully mineralized in the mutant

limbs/digits/tail
• develop six to seven digits per limb with complete formation of digits 2-5 (preaxial polydactyly)

growth/size/body
• the maxillary shelves are not fully mineralized in the mutant
• mutants have cleft secondary palate
• palatal shelves fail to fuse; at E15.5, skeletal staining further shows the presence of widely separated palatal shelves




Genotype
MGI:5049886
cn35
Allelic
Composition
Porcntm1.1Lcm/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Porcntm1.1Lcm mutation (0 available); any Porcn mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are recovered between E15.5 and E18.5

embryo
• at E6.5, mice fail to express Brachyury, an early mesoderm marker, unlike in wild-type mice




Genotype
MGI:5049887
cn36
Allelic
Composition
Porcntm1.1Lcm/Porcn+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Porcntm1.1Lcm mutation (0 available); any Porcn mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Focal dermal hypoplasia-like phenotypes in Porcntm1.1Lcm/Porcn+ Edil3Tg(Sox2-cre)1Amc/0 embryos

mortality/aging
• only 1 viable pup was produced from several litters

limbs/digits/tail
• tail hypoplasia at E17.5

integument
N
• mice exhibit normal keratinocyte development
• in one mouse produced on its ventral skin
• at E17.5, mice exhibit large patches of abnormally smooth, hair follicle-free epidermis unlike in wild-type mice
• mice exhibit dermal atrophy unlike wild-type mice

growth/size/body
• at E17.5
• at E17.5
• in one mouse produced

embryo
• tail/posterior axis truncation

craniofacial
• at E17.5

skeleton
• in severe cases

digestive/alimentary system
• at E17.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
focal dermal hypoplasia DOID:2120 OMIM:305600
J:173672




Genotype
MGI:3687546
cn37
Allelic
Composition
Disp1tm1Pab/Disp1tm1Pab
Shhtm2Chg/Shh+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1tm1Pab mutation (0 available); any Disp1 mutation (33 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Shhtm2Chg mutation (0 available); any Shh mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survive to at least E18.5

limbs/digits/tail
• digits show segmentation and calcification defects
• develop 6-7 digits per limb (preaxial polydactyly)




Genotype
MGI:3687543
cn38
Allelic
Composition
Shhtm1Chg/Shhtm2Chg
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Shhtm1Chg mutation (1 available); any Shh mutation (22 available)
Shhtm2Chg mutation (0 available); any Shh mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

limbs/digits/tail
• exhibit defective development of the carpal and tarsal bones in the central digit
• in the forelimb, digit 2 is replaced with a biphalangeal digit characteristic of digit 1
• in the hindlimb, digit 1 is replaced by digits with more posterior characteristics
• exhibit defective development of the carpal and tarsal bones in the central digit

skeleton
• exhibit defective development of the carpal and tarsal bones in the central digit
• exhibit defective development of the carpal and tarsal bones in the central digit




Genotype
MGI:3831189
cn39
Allelic
Composition
Edil3Tg(Sox2-cre)1Amc/Edil3+
Wnt7atm1Amc/Wnt7atm1Amc
Wnt7btm1Parr/Wnt7btm2Amc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Wnt7atm1Amc mutation (1 available); any Wnt7a mutation (10 available)
Wnt7btm1Parr mutation (1 available); any Wnt7b mutation (11 available)
Wnt7btm2Amc mutation (1 available); any Wnt7b mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all embryos die around E12.5 due to severe hemorrhaging within the central nervous system

cardiovascular system
• while vascularization has occurred within the ventral neural tube of control E10.5 embryos at the forelimb level, no such vascularization is observed in this region of mutant embryos
• in E12.5 embryos, endothelial cells and pericytes are absent from all ventral neural regions of the presumptive spinal cord except for in the floor plate
• in the dorsal neural tube of E12.5 embryos, endothelial cells and pericytes form abnormal clusters and enlarged lumens in the vascular structures present
• hemorrhaging is detected throughout the developing brain of E12.5 embryos
• hemorrhaging is detected throughout the developing spine of E12.5 embryos
• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

nervous system
• hemorrhaging is detected throughout the developing brain of E12.5 embryos
• hemorrhaging is detected throughout the developing spine of E12.5 embryos
• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos




Genotype
MGI:3693081
cn40
Allelic
Composition
Sall4tm2Tre/Sall4tm2.1Tre
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Sall4tm2.1Tre mutation (0 available); any Sall4 mutation (95 available)
Sall4tm2Tre mutation (0 available); any Sall4 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• embryo development is arrested at the late primitive streak stage, before somite development




Genotype
MGI:3807221
cn41
Allelic
Composition
Fzd5tm1Nat/Fzd5tm2Nat
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Fzd5tm1Nat mutation (1 available); any Fzd5 mutation (10 available)
Fzd5tm2Nat mutation (1 available); any Fzd5 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• animals exhibit 15-20% reduction in body size and weight

nervous system
• parafascicular nucleus (PFN) exhibits loss of 50% of all neurons, and nearly 100% of Fzd5-expressing neurons at 8 weeks
• neurons are present in normal numbers and show normal projections to the striatum at P1, then are gradually lost during the first postnatal month

behavior/neurological
• mice consistently show compromised performance in rotarod tests compared to heterozygous controls

vision/eye
• mice display slow retinal degeneration




Genotype
MGI:5470527
cn42
Allelic
Composition
Dag1tm1Kcam/Dag1tm2.1Kcam
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1tm1Kcam mutation (1 available); any Dag1 mutation (96 available)
Dag1tm2.1Kcam mutation (1 available); any Dag1 mutation (96 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice
• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice
• endfoot detachment
• at E11.5, commissural axons exhibit robust postcrossing trajectory defects with failure to project to the lateral portion of the funiculus and altered lateral and ventral funiculi ratio compared with wild-type mice
• at E13, a large number of commissural axons project abnormally within the floor plate unlike in wild-type mice
• at E13.5, mice exhibit extensive disruptions in more lateral aspect of the ventrolateral funiculus compared with wild-type mice
• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice

cellular
• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice
• mice exhibit abnormal formation of the descending hindbrain axonal tract and severe defasciculation of the spinal cord dorsal funiculus compared with wild-type mice
• endfoot detachment
• at E11.5, mice exhibit progressive fragmentation of the basement membrane surrounding the spinal cord which is accompanied by detachment of radial neuroepithelial endfeet from the basal surface unlike wild-type mice




Genotype
MGI:5795747
cn43
Allelic
Composition
Pnkptm1.1Pmc/Pnkptm1.1Pmc
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Pnkptm1.1Pmc mutation (0 available); any Pnkp mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• early lethality, with no embryos recovered after E9




Genotype
MGI:5620619
cn44
Allelic
Composition
Trim28tm1.1Ipc/Trim28tm1.2Ipc
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (16 available)
Trim28tm1.2Ipc mutation (0 available); any Trim28 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• embryos no normal yolk sac protrusions or trophoblast malformations
• shorter and wider than in control mice

nervous system

digestive/alimentary system
• failure of gut closure

cardiovascular system




Genotype
MGI:4360349
cn45
Allelic
Composition
Pak4tm2.1Amin/Pak4tm2.2Amin
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Pak4tm2.1Amin mutation (1 available); any Pak4 mutation (65 available)
Pak4tm2.2Amin mutation (0 available); any Pak4 mutation (65 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are recovered (no time point given)

embryo
• authors state that mice resemble Pak4tm1Amin
• authors state that mice resemble Pak4tm1Amin

growth/size/body




Genotype
MGI:4830326
cn46
Allelic
Composition
Trim33tm1.1Los/Trim33tm1.2Los
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Trim33tm1.1Los mutation (0 available); any Trim33 mutation (16 available)
Trim33tm1.2Los mutation (0 available); any Trim33 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• few embryos survive to E10

embryo
N
• unlike in homozygous germline null mice, no defects are seen in the anterior visceral endoderm or the extraembryonic ectoderm
• expression analysis indicates an almost radial expansion of the definitive endoderm at E7.5
• duplications of anterior axial mesendoderm tissues
• seen in about 1/3 of embryos that also have a defect in primitive streak morphology
• at E10 the few surviving embryos display open neural folds
• expanded in surviving embryos at E8.0
• duplications of node tissues
• about 1/3 of embryos lack an overtly elongated streak

nervous system
• at E10 the few surviving embryos display open neural folds
• at E10 the few surviving embryos display defective brain development

growth/size/body
• seen in about 1/3 of embryos that also have a defect in primitive streak morphology




Genotype
MGI:4456114
cn47
Allelic
Composition
Lama1tm1Olf/Lama1tm1Olf
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S2/SvPas * C57BL/6J * CBA * CD-1 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Lama1tm1Olf mutation (0 available); any Lama1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

The inner limiting membrane does not form in Lama1tm1Olf/Lama1tm1Olf Edil3Tg(Sox2-cre)1Amc/0 mice

mortality/aging
N
• normal lifespan

growth/size/body
• 13% reduction in birth weight, but by 8 weeks of age this weight difference is no longer observed

reproductive system
N
• normal fertility

vision/eye
• the vitreal vessels remain endostatin positive throughout adulthood
• at 1 year of age eye diameters are 11% larger than those of controls
• ophthalmoscopy shows vitreal fibroplasia, vessel tortuosity, and retinal spots that are larger and more prominent than those in nmf223 homozygotes
• larger vessels lie within the vitreous and cover the entire retinal surface, and there is a lack of primary plexus veins and arteries within the retina
• intermediate and deep vascular plexi are present in the retina but not as dense as those of nmf223 homozygotes
• Muller cells lacking end-feet with misguided and shortened processes are found
• the inner limiting membrane does not form properly
• peripheral loss of cells in the inner plexiform and both nuclear layers of the retina, which is more severe and has an earlier onset than that in nmf223 homozygotes

cardiovascular system
• larger vessels lie within the vitreous and cover the entire retinal surface, and there is a lack of primary plexus veins and arteries within the retina
• intermediate and deep vascular plexi are present in the retina but not as dense as those of nmf223 homozygotes

nervous system
• Muller cells lacking end-feet with misguided and shortened processes are found




Genotype
MGI:5050115
cn48
Allelic
Composition
Rac1tm1Tyb/Rac1tm2Tyb
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S4/SvJae * C3H * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Rac1tm1Tyb mutation (0 available); any Rac1 mutation (11 available)
Rac1tm2Tyb mutation (0 available); any Rac1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survive longer than germ line null mice
• survive until E8.5

embryo
• in the mesoderm and basal regions of the epiblast at E7.5
• at E6.5 and E7.5, cell death is increased in the anterior half of the embryo compared to the posterior half
• expression analysis indicates organization of midline structures is abnormal
• the midline is broad at E8.5
• mesoderm cells are specified but migration away from the primitive streak is impaired
• mesodermal cells are round, with just a few short protrusions
• the embryonic region is smaller compared to control littermates from E7.5 onwards
• expression analysis indicates the notochordal plate is wider and shorter at E7.75
• the neural plate is present but fails to initiate neural tube closure
• during epithelial to mesenchymal transition in the primitive streak breakdown of the basement membrane appears somewhat disrupted with large laminin aggregates seen on nascent mesodermal cells
• accumulation of T expressing cells in the primitive streak indicating an impairment in migration of cells away from the streak
• node cells are specified but fail to coalesce to form a normal node
• properly organized somites do not form

cellular
• cultured cells from E7.5 embryos fail to adhere to either fibronectin or Matrigel matrices
• in the mesoderm and basal regions of the epiblast at E7.5
• at E6.5 and E7.5, cell death is increased in the anterior half of the embryo compared to the posterior half
• decrease in the mitotic index in E7.5 embryos

cardiovascular system

growth/size/body
• the embryonic region is smaller compared to control littermates from E7.5 onwards

nervous system
• the neural plate is present but fails to initiate neural tube closure




Genotype
MGI:5140923
cn49
Allelic
Composition
Pdgfrbtm12(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Pdgfrbtm12(Pdgfrb)Sor mutation (0 available); any Pdgfrb mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:5140925
cn50
Allelic
Composition
Pdgfrbtm13(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Pdgfrbtm13(Pdgfrb)Sor mutation (1 available); any Pdgfrb mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body
• during the second week

cardiovascular system
• during the second week, mice exhibit thickening of the ascending aorta media compared with wild-type mice




Genotype
MGI:3814711
cn51
Allelic
Composition
Trpm7tm1Clph/Trpm7tm1.1Clph
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Trpm7tm1.1Clph mutation (0 available); any Trpm7 mutation (5 available)
Trpm7tm1Clph mutation (1 available); any Trpm7 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no viable embryos were found, no time of lethality was provided




Genotype
MGI:5470168
cn52
Allelic
Composition
Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvSvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Zic3tm2.1Jwb mutation (1 available); any Zic3 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• despite normal numbers at E15.5, fewer than expected mice at weaning

cardiovascular system
• separate entrance of hepatic veins in some mice
• in 5 of 32 mice at E9.5
• in some mice
• atrium isomerism in some mice
• in some mice
• in some mice

digestive/alimentary system
• in 4 of 38 mice at E15.5
• in some mice
• midline and right-sided stomach in some mice
• in some mice

embryo
• in some mice at E9.5
• in 14 of 32 mice
• in 4 of 38 mice at E15.5

growth/size/body
• in 4 of 38 mice at E15.5
• in 14 of 32 mice
• laterality defects in 2 of 8 mice
• in some mice

nervous system
• in 4 of 38 mice at E15.5
• in 4 of 38 mice at E15.5

behavior/neurological
• in some mice

vision/eye
• in some mice

skeleton

respiratory system
• pulmonary isomerism in some mice

limbs/digits/tail

craniofacial
• in 4 of 38 mice at E15.5




Genotype
MGI:5562566
cn53
Allelic
Composition
Dab2tm2.1Xxx/Dab2tm2.2Xxx
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab2tm2.1Xxx mutation (0 available); any Dab2 mutation (3 available)
Dab2tm2.2Xxx mutation (0 available); any Dab2 mutation (3 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• viable

homeostasis/metabolism
• serum total cholesterol level is slightly but consistently increased

embryo
N
• no gross developmental defects




Genotype
MGI:5140926
cn54
Allelic
Composition
Pdgfrbtm14(Pdgfrb)Sor/Pdgfrb+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Pdgfrbtm14(Pdgfrb)Sor mutation (1 available); any Pdgfrb mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• during the second week, mice exhibit thickening of the ascending aorta compared with wild-type mice

adipose tissue
N
• at P13, mice exhibit normal interscapular brown adipose tissue
• at P13, inguinal white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice
• at P13, only rudimentary mesenteric adipose depots are detected compared to in wild-type mice
• at P9, white adipose tissue exhibit a 1.5-fold increase in the stromal vascular fraction compared with wild-type tissue
• subcutaneous mesenchymal cells exhibit reduced white adipocyte differentiation in vitro compared with wild-type cells
• at P13, inguinal and subcutaneous white adipose tissues contain reduced lipids but higher cell density compared to in wild-type mice
• at P13, subcutaneous white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice

growth/size/body
• during the second week

integument
• at P13, subcutaneous white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice

cellular
• subcutaneous mesenchymal cells exhibit reduced white adipocyte differentiation in vitro compared with wild-type cells




Genotype
MGI:4360982
cn55
Allelic
Composition
Gt(ROSA)26Sortm1(Wnk1)Clhu/Gt(ROSA)26Sor+
Wnk1Gt(OST38262)Lex/Wnk1Gt(OST38262)Lex
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm1(Wnk1)Clhu mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
Wnk1Gt(OST38262)Lex mutation (1 available); any Wnk1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• expression of Wnk1 in the somatic embryonic cells fails to rescue the phenotypes seen in Wnk1 null embryos




Genotype
MGI:5791934
cn56
Allelic
Composition
Gli3tm1Alj/Gli3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gli3tm1Alj mutation (1 available); any Gli3 mutation (10 available)
Tgif1tm1Caw mutation (1 available); any Tgif1 mutation (27 available)
Tgif2tm1Dwot mutation (0 available); any Tgif2 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduced Gli3 levels partially rescues ventral forebrain morphology observed in double mutants with less disorganization and partially separated cephalic folds
• in half of mice at E18.5

embryo
• partially separated cephalic folds

craniofacial
• partially rescued nasal field separation defect

growth/size/body
• partially rescued nasal field separation defect

respiratory system
• partially rescued nasal field separation defect

taste/olfaction
• partially rescued nasal field separation defect




Genotype
MGI:5896533
cn57
Allelic
Composition
Nsdhltm1.1Hrm/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Nsdhltm1.1Hrm mutation (0 available); any Nsdhl mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• growth curve falls behind controls starting around P7




Genotype
MGI:5896532
cn58
Allelic
Composition
Nsdhltm1.1Hrm/Nsdhl+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Nsdhltm1.1Hrm mutation (0 available); any Nsdhl mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• patches of hairless skin
• patches of hyperkeratotic skin

growth/size/body

skeleton
• skeletal abnormalities




Genotype
MGI:5470273
cn59
Allelic
Composition
Gt(ROSA)26Sortm10(Gata2)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm10(Gata2)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5470271
cn60
Allelic
Composition
Gt(ROSA)26Sortm8(Aifm1)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm8(Aifm1)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice do not exhibit embryonic lethality




Genotype
MGI:5470268
cn61
Allelic
Composition
Gt(ROSA)26Sortm6(Vegfa*)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm6(Vegfa*)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5502197
cn62
Allelic
Composition
Gt(ROSA)26Sortm16Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm16Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• doxycycline-treated mouse embryonic fibroblasts or adult tail tip fibroblasts perform normally in embryoid body differentiation assays in terms of the formation of embryoid bodies, beating cardiomyocyes, sprouting vascular endothelial channels, or their hematopoietic differentiation potential




Genotype
MGI:5470266
cn63
Allelic
Composition
Gt(ROSA)26Sortm5(CAG-Mdm4,-EGFP)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm5(CAG-Mdm4,-EGFP)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are born in Mendelian ratios and show no overt phenotypes




Genotype
MGI:5470265
cn64
Allelic
Composition
Gt(ROSA)26Sortm3(Snai2)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm3(Snai2)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• variable

cardiovascular system
• cephalic hemorrhage at E14.5

integument
• at E14.5




Genotype
MGI:5470264
cn65
Allelic
Composition
Gt(ROSA)26Sortm4(Snai1)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm4(Snai1)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• severe developmental defects at E10.5




Genotype
MGI:5470274
cn66
Allelic
Composition
Gt(ROSA)26Sortm11(Gata3)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm11(Gata3)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice do not exhibit embryonic lethality




Genotype
MGI:5470272
cn67
Allelic
Composition
Gt(ROSA)26Sortm9(Aifm1*)Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm9(Aifm1*)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice do not exhibit embryonic lethality




Genotype
MGI:5470277
cn68
Allelic
Composition
Gt(ROSA)26Sortm14Jhai/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Gt(ROSA)26Sortm14Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice do not exhibit embryonic lethality




Genotype
MGI:5692456
cn69
Allelic
Composition
Eef1a1tm1Tcrl/Eef1a1+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Eef1a1tm1Tcrl mutation (1 available); any Eef1a1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• a high percentage of E12.5 embryos exhibit neural tube defects
• several E11.5 and E12.5 embryos exhibit spina bifida

mortality/aging
• fewer double heterozygous animals (4.6%) are produced than expected (25%) from a heterozygote x heterozygote mating
• a significant drop in viability occurs between E15.5 and birth
• no pups survive beyond P14

nervous system
• a high percentage of E12.5 embryos exhibit neural tube defects
• several E11.5 and E12.5 embryos exhibit spina bifida
• several E11.5 and E12.5 embryos exhibit holoprosencephaly




Genotype
MGI:5428021
cn70
Allelic
Composition
Fam20ctm1.1Cqi/Fam20ctm1.1Cqi
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Fam20ctm1.1Cqi mutation (1 available); any Fam20c mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Small size, flat face, hypomineralization, and distorted spine in Fam20ctm1.1Cqi/Fam20ctm1.1Cqi Edil3Tg(Sox2-cre)1Amc/0 mice

reproductive system

skeleton
• decrease in the percentage of apoptotic cells in the hypertrophic zone
• decrease in the absolute number of proliferating chondrocytes
• small skeleton
• downregulation of markers of terminal differentiation at 3 weeks of age
• at 1 week of age
• appearance of more porous areas in both the outer and inner bone surfaces
• increase in porosity
• the diaphysis region of the tibia has more osteoid/hypomineralized areas in the cortical bone
• reduced in size
• decrease in the absolute number of proliferating chondrocytes
• at 6 weeks of age
• significantly lower mineral Apparent Density and Material Density in the tibia midshaft region at 3 and 6 weeks of age
• appear immature
• both early stage differentiation and late stage maturation are affected
• lower levels of mineralization at 5 months of age
• significantly lower mineral deposition rate
• hypophosphatemic rickets
• in the ribs, long bones, and carpus at 1 weeks of age
• delay in secondary ossification centers in the epiphysis in the long bones and vertebrae at 6 weeks of age
• multiple fractures are often seen after 3 weeks of age

craniofacial
• at 1 week of age

growth/size/body
• smaller stature at 1 week of age
• prominent dwarfism at 4 weeks of age

homeostasis/metabolism
• at 18 and 42 days of age
• increase in serum FGF23 levels at 18 and 42 days of age
• the 1,25(OH)2D3 level is reduced at 18 days of age but not at 42 days of age

limbs/digits/tail
• appearance of more porous areas in both the outer and inner bone surfaces

cellular
• decrease in the percentage of apoptotic cells in the hypertrophic zone
• downregulation of markers of terminal differentiation at 3 weeks of age
• decrease in the absolute number of proliferating chondrocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rickets DOID:10609 OMIM:264700
OMIM:277440
OMIM:600081
OMIM:600785
J:185208




Genotype
MGI:5294952
cn71
Allelic
Composition
Psip1tm1Eng/Psip1tm1Eng
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Psip1tm1Eng mutation (1 available); any Psip1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cells exhibit defective HIV-1 integration compared with wild-type cells




Genotype
MGI:4360361
cn72
Allelic
Composition
Erbb3tm1.1Dwt/Erbb3tm2.1Dwt
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Erbb3tm1.1Dwt mutation (1 available); any Erbb3 mutation (7 available)
Erbb3tm2.1Dwt mutation (0 available); any Erbb3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice were detected (no time of death given)




Genotype
MGI:5532401
cn73
Allelic
Composition
Ubr4tm1.2Nkt/Ubr4tm1.2Nkt
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Ubr4tm1.2Nkt mutation (1 available); any Ubr4 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mild growth retardation and brain abnormalities in Ubr4tm1.2Nkt/Ubr4tm1.2Nkt Edil3Tg(Sox2-cre)1Amc/0 embryos

mortality/aging
• despite being present at E12.5 and E13.5, no mice are present at E14.5

cardiovascular system
• increased empty spaces (hepatic sinusoids) at E12.5; sinusoids are very dilated at E13.5
• increased ventricle volume at E12.5 and E13.5
• immature inferior atrioventricular endocardial cushion at E12
• immature at E12.5 and E13.5 with a large canal between left and right ventricle

nervous system
• compressed especially in the posterior portion
• area between the ventricles and cephalic mesenchyme tissue is reduced compared to in control mice
• severe cell death with cavitation in the lateral and medial ganglionic eminences, localized below the forebrain cortex
• severe cell death with cavitation in the lateral and medial ganglionic eminences, localized below the forebrain cortex

liver/biliary system
• increased empty spaces (hepatic sinusoids) at E12.5; sinusoids are very dilated at E13.5
• less densely packed
• at E12.5

embryo
N
• mice exhibit normal labyrinth layer structure and blood vessels of the labyrinth layer

growth/size/body
• bulges sticking up from the middle of the head at E12.5 and more evident at E13.5

cellular
• severe cell death with cavitation in the lateral and medial ganglionic eminences, localized below the forebrain cortex
• in the heart at E13.5 without an increase in apoptosis




Genotype
MGI:3723508
cn74
Allelic
Composition
Esrrbtm1.1Nat/Esrrbtm1.2Nat
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Esrrbtm1.1Nat mutation (1 available); any Esrrb mutation (237 available)
Esrrbtm1.2Nat mutation (0 available); any Esrrb mutation (237 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• no auditory startle reflex
• observed beginning at several weeks of age
• adults spin or run in circles

hearing/vestibular/ear
• collapsed at 7 days of age
• reduction in volume seen at 4 days of age
• narrowing of membranous labyrinths of the three semicircular canals is observed in postnatal animals