Phenotypes associated with this allele

• Allele Symbol: Hs3st1^tm1Nws
• Allele Name: targeted mutation 1, Nicholas W Shworak
• Allele ID: MGI:2655749
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hs3st1^tm1Nws/Hs3st1^tm1Nws	B6.129S2-Hs3st1^tm1Nws	MGI:2655753
hm2	Hs3st1^tm1Nws/Hs3st1^tm1Nws	involves: 129S2/SvPas * 129S4/SvJae	MGI:2655755

Genotype
MGI:2655753

hm1

• Allelic Composition: Hs3st1^tm1Nws/Hs3st1^tm1Nws
• Genetic Background: B6.129S2-Hs3st1^tm1Nws

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:82622 )

• Background Sensitivity: death occurs around P2-P3 on a C57BL/6 background

embryo

decreased embryo weight ( J:82622 )

• embryos weigh 20% less than wild-type

growth/size/body

decreased embryo weight ( J:82622 )

• embryos weigh 20% less than wild-type

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:82622 )

N • despite a reduction in anticoagulant heparan sulfate, mutants maintain normal levels of tissue fibrin accumulation under normoxic and hypoxic conditions, show no obvious procoagulant phenotype, exhibit normal responses to carotid artery injury, and show no evidence of placental vascular insufficiency

Genotype
MGI:2655755

hm2

• Allelic Composition: Hs3st1^tm1Nws/Hs3st1^tm1Nws
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

mortality/aging

mortality/aging ( J:82622 )

N • Background Sensitivity: unlike on a C57BL/6 background where death occurs at P2-P3, mice on a mixed 129S2/SvPas and 129S4/SvJae genentic background do not exhibt lethality