Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation
(0 available);
any
Anxa5 mutation
(22 available)
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normal phenotype
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• mice are viable, fertile and develop normally; normal formation and maintenance of skeletal elements; normal clinical-chemical parameters
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation
(0 available);
any
Anxa5 mutation
(22 available)
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immune system
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• LPS-activated peritoneal macrophages show higher secretion of IL-10 than wild-type macrophages in response to mechanical stress-induced necrotic cells
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• mutant macrophages show a more anti-inflammatory and immunosuppressive potential in response to mechanical stress-induced necrotic cells
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• mutants do not show an allogeneic reaction against cells necrotized by mechanical stress, whereas wild-type mice show a strong reaction
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation
(0 available);
any
Anxa5 mutation
(22 available)
Anxa6tm1Moss mutation
(2 available);
any
Anxa6 mutation
(42 available)
Col10a1tm1Ksec mutation
(0 available);
any
Col10a1 mutation
(27 available)
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immune system
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• decreased CD11c+ dendritic cells at 1 year in female mice
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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• CD4+/CD8- T-helper cells at 1 year in the spleen
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skeleton
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• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
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• with increased cell numbers
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limbs/digits/tail
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• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
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hematopoietic system
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• decreased CD11c+ dendritic cells at 1 year in female mice
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• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
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• CD4+/CD8- T-helper cells at 1 year in the spleen
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation
(0 available);
any
Anxa5 mutation
(22 available)
Anxa6tm1Moss mutation
(2 available);
any
Anxa6 mutation
(42 available)
|
|
|
immune system
|
• decreased CD11c+ dendritic cells at 1 year in female mice
|
|
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
|
hematopoietic system
|
• decreased CD11c+ dendritic cells at 1 year in female mice
|
|
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
|