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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd40tm1Geha
targeted mutation 1, Raif S Geha
MGI:2655321
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd40tm1Geha/Cd40tm1Geha involves: 129S4/SvJae * C57BL/6 MGI:3841417
cx2
 		Btktm1Wk/Btktm1Wk
Cd40tm1Geha/Cd40tm1Geha 		involves: 129S4/SvJae * C57BL/6 MGI:2655323


Genotype
MGI:3841417
hm1
Allelic
Composition		 Cd40tm1Geha/Cd40tm1Geha
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40tm1Geha mutation (0 available); any Cd40 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased spleen germinal center number ( J:82298 )
• germinal centers are infrequent in TNP-LPS immunized mutants
decreased spleen germinal center size ( J:82298 )
• germinal centers are smaller in TNP-LPS immunized mutants
abnormal lymph node germinal center morphology ( J:82298 )
• smaller and fewer germinal centers are observed in response to TI-I antigen, TNP-LPS

hematopoietic system
decreased spleen germinal center number ( J:82298 )
• germinal centers are infrequent in TNP-LPS immunized mutants
decreased spleen germinal center size ( J:82298 )
• germinal centers are smaller in TNP-LPS immunized mutants




Genotype
MGI:2655323
cx2
Allelic
Composition		 Btktm1Wk/Btktm1Wk
Cd40tm1Geha/Cd40tm1Geha
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Wk mutation (1 available); any Btk mutation (22 available)
Cd40tm1Geha mutation (0 available); any Cd40 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell proliferation ( J:82298 )
• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type
decreased B cell number ( J:82298 )
• severe deficiency of B cells in the spleen and lymph nodes compared to single Btk homozygotes; total numbers of B220+IgM+ B cells in the spleen are 3-4 fold reduced relative to single Btk homozygotes and 7-8 fold reduced relative to wild-type or single Cd40 homozygotes
• B cell deficiency is more severe in the lymph node than in spleen
decreased mature B cell number ( J:82298 )
• mature recirculating B cells (B220highIgM+, HSAlowIgM+, and B220+IgD+) are reduced more than in single Btk homozygotes
absent spleen germinal center ( J:82298 )
• absence of germinal center formation in response to TI-I antigen stimulation
decreased IgA level ( J:82298 )
• 40-fold reduction compared to single CD40 homozygote
decreased IgG2a level ( J:82298 )
• similar decrease to that seen in single CD40 homozygotes
decreased IgG2b level ( J:82298 )
• 10-fold reduction compared to single CD40 homozygote
decreased IgG3 level ( J:82298 )
• similar decrease to that seen in single Btk homozygotes
decreased IgM level ( J:82298 )
• 7-fold reduction compared to single Btk homozygote

immune system
decreased B cell proliferation ( J:82298 )
• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type
decreased B cell number ( J:82298 )
• severe deficiency of B cells in the spleen and lymph nodes compared to single Btk homozygotes; total numbers of B220+IgM+ B cells in the spleen are 3-4 fold reduced relative to single Btk homozygotes and 7-8 fold reduced relative to wild-type or single Cd40 homozygotes
• B cell deficiency is more severe in the lymph node than in spleen
decreased mature B cell number ( J:82298 )
• mature recirculating B cells (B220highIgM+, HSAlowIgM+, and B220+IgD+) are reduced more than in single Btk homozygotes
absent spleen germinal center ( J:82298 )
• absence of germinal center formation in response to TI-I antigen stimulation
absent lymph node germinal center ( J:82298 )
• absence of germinal center formation in response to TI-I antigen stimulation
abnormal humoral immune response ( J:82298 )
• defective IgM and IgG response to TI antigen and TD antigen stimulation
decreased IgA level ( J:82298 )
• 40-fold reduction compared to single CD40 homozygote
decreased IgG2a level ( J:82298 )
• similar decrease to that seen in single CD40 homozygotes
decreased IgG2b level ( J:82298 )
• 10-fold reduction compared to single CD40 homozygote
decreased IgG3 level ( J:82298 )
• similar decrease to that seen in single Btk homozygotes
decreased IgM level ( J:82298 )
• 7-fold reduction compared to single Btk homozygote

cellular
decreased B cell proliferation ( J:82298 )
• in vitro, B cells show a reduced level of proliferation in response to LPS compared to wild-type




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory