About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxp3tm1.1Ayr
targeted mutation 1.1, Alexander Y Rudensky
MGI:2654936
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Foxp3tm1.1Ayr/Foxp3tm1.1Ayr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3699143
cx2
Foxp3tm1.1Ayr/Foxp3tm1.1Ayr
Mir146tm1.1Bal/Mir146tm1.1Bal
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4887824
cx3
Foxp3tm1.1Ayr/Y
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
Not Specified MGI:3574972
ot4
Foxp3tm1.1Ayr/Y involves: 129S1/Sv * 129X1/SvJ MGI:2654941
ot5
Foxp3tm1.1Ayr/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3699150


Genotype
MGI:3699143
hm1
Allelic
Composition
Foxp3tm1.1Ayr/Foxp3tm1.1Ayr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation (0 available); any Foxp3 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• observed in 3-week old mutants
• the number of CD44+CD25- DN1 cells is increased
• observed in 3-week old female mutants
• massive lymphocytic and mononuclear infiltrates in liver sinusoids of females seen at 3 weeks
• massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks
• massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in females; not seen in control littermates

hematopoietic system
• observed in 3-week old mutants
• the number of CD44+CD25- DN1 cells is increased

liver/biliary system
• massive lymphocytic and mononuclear infiltrates in liver sinusoids of females seen at 3 weeks

respiratory system
• massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks

integument
• massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in females; not seen in control littermates
• tail scaling is observed

endocrine/exocrine glands

growth/size/body
• observed in 3-week old mutants




Genotype
MGI:4887824
cx2
Allelic
Composition
Foxp3tm1.1Ayr/Foxp3tm1.1Ayr
Mir146tm1.1Bal/Mir146tm1.1Bal
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation (0 available); any Foxp3 mutation (55 available)
Mir146tm1.1Bal mutation (2 available); any Mir146 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• soon after 5 weeks when bone marrow is used to reconstitute wild-type mice

immune system
• when bone marrow is used to reconstitute wild-type mice
• 6-7 weeks after transfer, massive lymphocyte activation and tissue infiltration in the lung, liver, and skin is observed when bone marrow is used to reconstitute wild-type mice
• in T cells when bone marrow is used to reconstitute wild-type mice
• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice

integument
• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice

vision/eye
• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice

hematopoietic system
• when bone marrow is used to reconstitute wild-type mice
• 6-7 weeks after transfer, massive lymphocyte activation and tissue infiltration in the lung, liver, and skin is observed when bone marrow is used to reconstitute wild-type mice




Genotype
MGI:3574972
cx3
Allelic
Composition
Foxp3tm1.1Ayr/Y
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraTcrb)425Cbn/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation (0 available); any Foxp3 mutation (55 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Tg(TcraTcrb)425Cbn mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit no differences in thymocyte and peripheral T cell subpopulations and normal antigen sensitivity, costimulation requirement and proliferative capacity of nonregulatory CD4+ T cells

normal phenotype
• mice were healthy and phenotypically indistinguishable from controls




Genotype
MGI:2654941
ot4
Allelic
Composition
Foxp3tm1.1Ayr/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation (0 available); any Foxp3 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at P21, male hemizygotes exhibit an extremely enlarged spleen
• mutant CD4+ T cells exhibit an activated phenotype, showing increased CD69, CD44, CTLA-4 and GITR expression along with decreased expression of CD62L relative to wild-type CD4+ T cells
• at P10, male hemizygotes display a significantly reduced CD4+CD25+ regulatory T cell population in both the lymph node and thymus relative to wild-type mice (0.4% and 0.6% vs 3.0% and 3.8%, respectively)
• at P21, male hemizygotes exhibit extremely enlarged lymph nodes
• male hemizygotes become moribund at ~4 weeks of age and eventually succumb to aggressive lymphoproliferative autoimmunity
• overt signs of disease are first evident at ~P12, and include runting and scaly and inflamed skin on the ears and tail
• skin inflammation on the ears and tail, first evident at ~P12

hematopoietic system
• at P21, male hemizygotes exhibit an extremely enlarged spleen
• mutant CD4+ T cells exhibit an activated phenotype, showing increased CD69, CD44, CTLA-4 and GITR expression along with decreased expression of CD62L relative to wild-type CD4+ T cells
• at P10, male hemizygotes display a significantly reduced CD4+CD25+ regulatory T cell population in both the lymph node and thymus relative to wild-type mice (0.4% and 0.6% vs 3.0% and 3.8%, respectively)

growth/size/body
• runting is first evident at ~P12
• at P21, male hemizygotes exhibit an extremely enlarged spleen

craniofacial

hearing/vestibular/ear

integument
• skin inflammation on the ears and tail, first evident at ~P12
• scaly skin on the ears and tail, frist evident at ~P12




Genotype
MGI:3699150
ot5
Allelic
Composition
Foxp3tm1.1Ayr/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation (0 available); any Foxp3 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• observed in 3-week old mutants

immune system
• observed in 3-week old mutants
• observed in 3-week old mutants
• massive lymphocytic and mononuclear infiltrates in liver sinusoids seen at 3 weeks
• massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks
• massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in hemizygous males; not seen in control littermates

liver/biliary system
• massive lymphocytic and mononuclear infiltrates in liver sinusoids seen at 3 weeks

respiratory system
• massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks

integument
• massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in hemizygous males; not seen in control littermates
• tail scaling is observed

growth/size/body
• observed in 3-week old mutants





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory