Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation
(0 available);
any
Foxp3 mutation
(55 available)
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immune system
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• observed in 3-week old mutants
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• the number of CD44+CD25- DN1 cells is increased
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• observed in 3-week old female mutants
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• massive lymphocytic and mononuclear infiltrates in liver sinusoids of females seen at 3 weeks
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• massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks
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• massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in females; not seen in control littermates
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hematopoietic system
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• observed in 3-week old mutants
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• the number of CD44+CD25- DN1 cells is increased
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liver/biliary system
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• massive lymphocytic and mononuclear infiltrates in liver sinusoids of females seen at 3 weeks
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respiratory system
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• massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks
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integument
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• massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in females; not seen in control littermates
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• tail scaling is observed
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endocrine/exocrine glands
growth/size/body
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• observed in 3-week old mutants
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation
(0 available);
any
Foxp3 mutation
(55 available)
Mir146tm1.1Bal mutation
(2 available);
any
Mir146 mutation
(9 available)
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mortality/aging
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• soon after 5 weeks when bone marrow is used to reconstitute wild-type mice
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immune system
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• when bone marrow is used to reconstitute wild-type mice
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• 6-7 weeks after transfer, massive lymphocyte activation and tissue infiltration in the lung, liver, and skin is observed when bone marrow is used to reconstitute wild-type mice
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• in T cells when bone marrow is used to reconstitute wild-type mice
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• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
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• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
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• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
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integument
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• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
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vision/eye
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• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
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• as early as 5 weeks when bone marrow is used to reconstitute wild-type mice
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hematopoietic system
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• when bone marrow is used to reconstitute wild-type mice
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• 6-7 weeks after transfer, massive lymphocyte activation and tissue infiltration in the lung, liver, and skin is observed when bone marrow is used to reconstitute wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation
(0 available);
any
Foxp3 mutation
(55 available)
Rag1tm1Mom mutation
(49 available);
any
Rag1 mutation
(120 available)
Tg(TcraTcrb)425Cbn mutation
(3 available)
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immune system
N |
• mice exhibit no differences in thymocyte and peripheral T cell subpopulations and normal antigen sensitivity, costimulation requirement and proliferative capacity of nonregulatory CD4+ T cells
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normal phenotype
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• mice were healthy and phenotypically indistinguishable from controls
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Allelic Composition |
Foxp3tm1.1Ayr/Y
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation
(0 available);
any
Foxp3 mutation
(55 available)
|
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immune system
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• at P21, male hemizygotes exhibit an extremely enlarged spleen
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• mutant CD4+ T cells exhibit an activated phenotype, showing increased CD69, CD44, CTLA-4 and GITR expression along with decreased expression of CD62L relative to wild-type CD4+ T cells
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• at P10, male hemizygotes display a significantly reduced CD4+CD25+ regulatory T cell population in both the lymph node and thymus relative to wild-type mice (0.4% and 0.6% vs 3.0% and 3.8%, respectively)
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• at P21, male hemizygotes exhibit extremely enlarged lymph nodes
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• male hemizygotes become moribund at ~4 weeks of age and eventually succumb to aggressive lymphoproliferative autoimmunity
• overt signs of disease are first evident at ~P12, and include runting and scaly and inflamed skin on the ears and tail
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• skin inflammation on the ears and tail, first evident at ~P12
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hematopoietic system
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• at P21, male hemizygotes exhibit an extremely enlarged spleen
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• mutant CD4+ T cells exhibit an activated phenotype, showing increased CD69, CD44, CTLA-4 and GITR expression along with decreased expression of CD62L relative to wild-type CD4+ T cells
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• at P10, male hemizygotes display a significantly reduced CD4+CD25+ regulatory T cell population in both the lymph node and thymus relative to wild-type mice (0.4% and 0.6% vs 3.0% and 3.8%, respectively)
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growth/size/body
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• runting is first evident at ~P12
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• at P21, male hemizygotes exhibit an extremely enlarged spleen
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craniofacial
hearing/vestibular/ear
integument
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• skin inflammation on the ears and tail, first evident at ~P12
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• scaly skin on the ears and tail, frist evident at ~P12
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Allelic Composition |
Foxp3tm1.1Ayr/Y
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1.1Ayr mutation
(0 available);
any
Foxp3 mutation
(55 available)
|
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hematopoietic system
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• observed in 3-week old mutants
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immune system
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• observed in 3-week old mutants
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• observed in 3-week old mutants
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• massive lymphocytic and mononuclear infiltrates in liver sinusoids seen at 3 weeks
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• massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks
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• massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in hemizygous males; not seen in control littermates
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liver/biliary system
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• massive lymphocytic and mononuclear infiltrates in liver sinusoids seen at 3 weeks
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respiratory system
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• massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks
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integument
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• massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in hemizygous males; not seen in control littermates
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• tail scaling is observed
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growth/size/body
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• observed in 3-week old mutants
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