Phenotypes associated with this allele
Allelic Composition |
Rnf2tm1Mvl/Rnf2tm1Mvl
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Genetic Background |
either: (involves: 129/Ola) or (involves: 129/Ola * FVB) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf2tm1Mvl mutation
(0 available);
any
Rnf2 mutation
(36 available)
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mortality/aging
embryo
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• accumulation of posterior mesoderm
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• mutants are delayed in development at E6.5-E8.5 and never reach the headfold stage
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• epiblast fails to expand normally
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1tm1Brn mutation
(2 available);
any
Bmi1 mutation
(33 available)
Rnf2tm1Mvl mutation
(0 available);
any
Rnf2 mutation
(36 available)
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mortality/aging
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• mutants die at 4-5 weeks of age, earlier than single homozygous Bmi1 mutants
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growth/size/body
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• delay in postnatal development at P10, from which point onward, growth ceases almost entirely
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behavior/neurological
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• severe lack of coordination
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• mutants exhibit a more abnormal gait than single homozygous Bmi1 mutants
impaired coordination [MP:0001405
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nervous system
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• arborization of Purkinje cells in the molecular layer is different, with thicker and less branched dendrites
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• reduction in cellularity and size of the granular layer of the cerebellum
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• reduction in cellularity and size of the molecular layer of the cerebellum
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skeleton
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• mutants exhibit axial skeleton abnormalities in the cervical, thoracic, lumbar and sacral regions
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation
(6 available);
any
Cdkn2a mutation
(62 available)
Rnf2tm1Mvl mutation
(0 available);
any
Rnf2 mutation
(36 available)
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embryo
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• development does not progress past E11-E12
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• some somites are laid down in paraxial mesoderm which is never observed in Rnf2 homozygotes
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nervous system
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• abnormal forebrain development with a near complete lack of head mesenchyme
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