All Phenotypes Brca2<tm2Hst> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca2^tm2Hst
targeted mutation 2, Paul Hasty
MGI:2653914

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca2^tm2Hst/Brca2^tm2Hst	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653930
ht2	Brca2^tm1Hst/Brca2^tm2Hst	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653931

Allelic Composition	Brca2^tm2Hst/Brca2^tm2Hst
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm2Hst mutation (0 available); any Brca2 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:82434 )

Allelic Composition	Brca2^tm1Hst/Brca2^tm2Hst
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Hst mutation (0 available); any Brca2 mutation (132 available)
Brca2^tm2Hst mutation (0 available); any Brca2 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

early cellular replicative senescence ( J:82434 )

• primary MEFs senesce prematurely in culture

chromosomal instability ( J:82434 )

• primary MEFs have higher numbers of chromosomal aberrations even at passage 2 and accumulate further aberrations more rapidly than wild-type MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23