Phenotypes associated with this allele

• Allele Symbol: Brca2^tm1Hst
• Allele Name: targeted mutation 1, Paul Hasty
• Allele ID: MGI:2653913
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca2^tm1Hst/Brca2^tm1Hst	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653927
ht2	Brca2^tm1Hst/Brca2^tm2Hst	involves: 129S7/SvEvBrd * C57BL/6	MGI:2653931

Genotype
MGI:2653927

hm1

• Allelic Composition: Brca2^tm1Hst/Brca2^tm1Hst
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:82434 )

• about 50% of mutants die by 89-90 weeks compared to 104-108 weeks for 50% of the controls

neoplasm

increased lymphoma incidence ( J:82434 )

increased carcinoma incidence ( J:82434 )

decreased tumor latency ( J:82434 )

• earlier onset of cancer than in controls; 20% of mutants develop either cancer or sepsis from 67 to 104 weeks of age compared to controls that do so at week 104

immune system

sepsis ( J:82434 )

• earlier onset of sepsis than in controls; 20% of mutants develop either cancer or sepsis from 67 to 104 weeks of age compared to controls that do so at week 104

Genotype
MGI:2653931

ht2

• Allelic Composition: Brca2^tm1Hst/Brca2^tm2Hst
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

cellular

early cellular replicative senescence ( J:82434 )

• primary MEFs senesce prematurely in culture

chromosomal instability ( J:82434 )

• primary MEFs have higher numbers of chromosomal aberrations even at passage 2 and accumulate further aberrations more rapidly than wild-type MEFs