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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trpm5tm1Csz
targeted mutation 1, Charles S Zuker
MGI:2653340
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trpm5tm1Csz/Trpm5tm1Csz involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2653341
cx2
Trpm4tm1.1Knt/Trpm4tm1.1Knt
Trpm5tm1Csz/Trpm5tm1Csz
involves: 129S1/Sv * 129X1/SvJ MGI:3817414


Genotype
MGI:2653341
hm1
Allelic
Composition
Trpm5tm1Csz/Trpm5tm1Csz
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm5tm1Csz mutation (1 available); any Trpm5 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
taste/olfaction
• nerve responses to sweet, amino acid, and bitter stimuli were abolished
• normal nerve responses to salty or sour stimuli
• preference for sweet, amino acid or bitter vs. water abolished
• preference for salty or sour vs. water similar to controls




Genotype
MGI:3817414
cx2
Allelic
Composition
Trpm4tm1.1Knt/Trpm4tm1.1Knt
Trpm5tm1Csz/Trpm5tm1Csz
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm4tm1.1Knt mutation (0 available); any Trpm4 mutation (32 available)
Trpm5tm1Csz mutation (1 available); any Trpm5 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in the spleen compared to Trpm5tm1Csz homozygotes

immune system
• in the spleen compared to Trpm5tm1Csz homozygotes
• activated dendritic cells exhibit increased calcium ion concentrations compared to in Trpm5tm1Csz homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory