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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rhbdf2cub
curly bare
MGI:2653121
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rhbdf2cub/Rhbdf2cub B6.Cg-Rhbdf2cub MGI:2653142
hm2
Rhbdf2cub/Rhbdf2cub MRL.Cg-Rhbdf2cub MGI:6256982
cx3
Rhbdf2cub/Rhbdf2cub
AregMcub/Areg+
involves: C57BL/6J * STOCK a us/J * V/LeJ MGI:2653152


Genotype
MGI:2653142
hm1
Allelic
Composition
Rhbdf2cub/Rhbdf2cub
Genetic
Background
B6.Cg-Rhbdf2cub
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf2cub mutation (2 available); any Rhbdf2 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit more rapid wound healing in an ear punch assay than wild-type mice
• bone-marrow engraftment from mutant donor mice into slow-healing wild-type recipient mice fail to transfer the cutaneous rapid wound-healing

immune system
• mild to moderate inflammation in white adipose tissue, with mixed cellular infiltrates in the subdermal adipose tissue

endocrine/exocrine glands
• described as hyperplastic (J:82006)

adipose tissue
• mild to moderate inflammation in white adipose tissue, with mixed cellular infiltrates in the subdermal adipose tissue

pigmentation
• irregular melanin granules

integument
• described as hyperplastic (J:82006)
• mice are almost hairless by 10 days of age, but remain covered with sparse, short, kinky hair (J:82006)
• complete hair loss throughout life (J:244160)
• tapered distal ends that terminate in the midshaft of the follicle or close to the surface; absent hair cells
• irregular melanin granules
• follicular dystrophy (J:244160)
• follicular dystrophy (J:250259)
• mutant mice receiving skin grafts from wild-type mice retain the skin phenotype of the donor mouse, with no follicular dystrophy and normal hair growth in the grafts (J:250259)
• skin grafts from mutant mice exhibit follicular dystrophy following transplantation onto wild-type mice (J:250259)
• abnormal inner root sheath; wider and irregular in shape
• densely fibrotic dermis with moderate inflammation of anagen skin
• denser collagen
• densely fibrotic dermis with moderate inflammation of anagen skin




Genotype
MGI:6256982
hm2
Allelic
Composition
Rhbdf2cub/Rhbdf2cub
Genetic
Background
MRL.Cg-Rhbdf2cub
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf2cub mutation (2 available); any Rhbdf2 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice show complete hair loss
• follicular dystrophy
• mouse embryonic keratinocytes produce higher levels of amphiregulin after stimulation with phorbol-12-myristate-12-acetate

endocrine/exocrine glands

homeostasis/metabolism
• Background Sensitivity: mice on a MRL/MpJ background exhibit accelerated wound healing in an ear punch assay compared to mice on the C57BL/6 background

cellular
• mouse embryonic fibroblasts produce higher levels of amphiregulin after stimulation with phorbol-12-myristate-12-acetate




Genotype
MGI:2653152
cx3
Allelic
Composition
Rhbdf2cub/Rhbdf2cub
AregMcub/Areg+
Genetic
Background
involves: C57BL/6J * STOCK a us/J * V/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AregMcub mutation (1 available); any Areg mutation (7 available)
Rhbdf2cub mutation (2 available); any Rhbdf2 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory