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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(KRT14-cre)1Cgn
transgene insertion 1, University of Cologne
MGI:2652655
Summary 30 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Vegfatm2Gne/Vegfatm2Gne
Lyz2tm1(cre)Ifo/Lyz2+
Tg(KRT14-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA * FVB/N MGI:5444295
cn2
Cebpatm1Gonz/Cebpa+
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4366854
cn3
Cebpatm1Gonz/Cebpatm2Nerl
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4366855
cn4
Cebpatm1Gonz/Cebpatm9Nerl
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4366856
cn5
Cebpatm1Gonz/Cebpatm1Gonz
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4366857
cn6
Myd88tm1Aki/Myd88tm1Aki
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2 MGI:7256624
cn7
Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy
Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285675
cn8
Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285681
cn9
Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5285682
cn10
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5582487
cn11
Chuktm1Yhu/Chuktm1Yhu
Tg(KRT14-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3817620
cn12
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2 MGI:7256612
cn13
Ifnar1tm1Agt/Ifnar1tm1Agt
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2 MGI:7256625
cn14
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * DBA/2 MGI:5582492
cn15
Resttm1.1Yasu/Rest+
Tg(KRT14-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:6241529
cn16
Resttm1.1Yasu/Resttm1.1Yasu
Tg(KRT14-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:6241532
cn17
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(KRT14-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:5582488
cn18
Chuktm1Mpa/Chuktm1Mpa
Tg(KRT14-cre)1Cgn/?
involves: C57BL/6 MGI:3714173
cn19
Otulinem1Gvl/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2 MGI:7256600
cn20
Snap29tm1c(EUCOMM)Wtsi/Snap29tm1c(EUCOMM)Wtsi
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * C57BL/6N * DBA/2 MGI:5812300
cn21
Faddtm1Mpa/Faddtm1Mpa
Mlkltm1.1Wsa/Mlkltm1.1Wsa
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * C57BL/6N * DBA/2 MGI:7256619
cn22
Mlkltm1.1Wsa/Mlkltm1.1Wsa
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * C57BL/6N * DBA/2 MGI:7256622
cn23
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * C57BL/6N * DBA/2 MGI:7256626
cn24
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Il22ra1tm1Rsab/Il22ra1tm1Rsab
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * DBA/2 MGI:5582486
cn25
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Il20ratm1Rsab/Il20ratm1Rsab
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * DBA/2 MGI:5582485
cn26
Trim16tm1Gmma/Trim16+
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * DBA/2 MGI:6479658
cn27
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * DBA/2 MGI:5582490
cn28
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Il22tm1Jcrd/Il22tm1Jcrd
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * DBA/2 MGI:5582491
cn29
Trim16tm1Gmma/Trim16tm1Gmma
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * DBA/2 MGI:6479659
cn30
Dbitm2.1Smdp/Dbitm2.2Smdp
Tg(KRT14-cre)1Cgn/0
involves: C57BL/6 * DBA/2 * FVB/N MGI:5538741


Genotype
MGI:5444295
cn1
Allelic
Composition
Vegfatm2Gne/Vegfatm2Gne
Lyz2tm1(cre)Ifo/Lyz2+
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Vegfatm2Gne mutation (1 available); any Vegfa mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• during the early and middle phases of wound healing, mice exhibit reduced formation and vascularization of granulation tissue compared with control mice




Genotype
MGI:4366854
cn2
Allelic
Composition
Cebpatm1Gonz/Cebpa+
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation (1 available); any Cebpa mutation (16 available)
Cebpbtm1Nerl mutation (0 available); any Cebpb mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• mice have normal epidermis




Genotype
MGI:4366855
cn3
Allelic
Composition
Cebpatm1Gonz/Cebpatm2Nerl
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation (1 available); any Cebpa mutation (16 available)
Cebpatm2Nerl mutation (0 available); any Cebpa mutation (16 available)
Cebpbtm1Nerl mutation (0 available); any Cebpb mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:4366856
cn4
Allelic
Composition
Cebpatm1Gonz/Cebpatm9Nerl
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation (1 available); any Cebpa mutation (16 available)
Cebpatm9Nerl mutation (0 available); any Cebpa mutation (16 available)
Cebpbtm1Nerl mutation (0 available); any Cebpb mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:4366857
cn5
Allelic
Composition
Cebpatm1Gonz/Cebpatm1Gonz
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation (1 available); any Cebpa mutation (16 available)
Cebpbtm1Nerl mutation (0 available); any Cebpb mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 5 to 8 hours of birth

growth/size/body
• at birth mice loss weight rapidly likely due to severe transepithelial water loss without lipophilic barrier dysfunction

vision/eye

integument
• the interfollicular epidermis exhibits an immature phenotype with fewer and smaller keratohyalin granules in the stratum granulosum and immature non-scaling stratum corneum and parakeratosis compared with wild-type mice

cellular




Genotype
MGI:7256624
cn6
Allelic
Composition
Myd88tm1Aki/Myd88tm1Aki
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Aki mutation (9 available); any Myd88 mutation (47 available)
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• no skin lesions and normal epidermal thickness




Genotype
MGI:5285675
cn7
Allelic
Composition
Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy
Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb1tm1.1Sgy mutation (1 available); any Lmnb1 mutation (38 available)
Lmnb2tm1.1Sgy mutation (1 available); any Lmnb2 mutation (27 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born at Mendelian frequency and survive for over 2 years

integument
N
• keratinocytes exhibit normal proliferation
• mice exhibit normal skin and hair
• keratinocytes exhibit an increase in misshapen cell nuclei and nuclear blebs in culture compared with wild-type cells
• however, no polyploidy is observed




Genotype
MGI:5285681
cn8
Allelic
Composition
Lmnb1tm1.1Sgy/Lmnb1tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb1tm1.1Sgy mutation (1 available); any Lmnb1 mutation (38 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born at Mendelian frequency and survive for over 2 years




Genotype
MGI:5285682
cn9
Allelic
Composition
Lmnb2tm1.1Sgy/Lmnb2tm1.1Sgy
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb2tm1.1Sgy mutation (1 available); any Lmnb2 mutation (27 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born at Mendelian frequency and survive for over 2 years




Genotype
MGI:5582487
cn10
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• mice reach adulthood without showing inflammatory skin lesions




Genotype
MGI:3817620
cn11
Allelic
Composition
Chuktm1Yhu/Chuktm1Yhu
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation (0 available); any Chuk mutation (48 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• at birth, some mice resemble Chuktm1Mpa homozygotes
• some mice exhibit epidermal hyperplasia after birth




Genotype
MGI:7256612
cn12
Allelic
Composition
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal circulating inflammatory cytokine and chemokine levels

integument
N
• no dermatitis and normal epidermal thickness up to age older than 40 weeks




Genotype
MGI:7256625
cn13
Allelic
Composition
Ifnar1tm1Agt/Ifnar1tm1Agt
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation (11 available); any Ifnar1 mutation (59 available)
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal circulating inflammatory cytokine and chemokine levels in most mice
• delineated inflamed skin lesions from age 6 weeks in some mice

integument
N
• no skin lesions and normal epidermal thickness in most mice
• delineated inflamed skin lesions from age 6 weeks in some mice




Genotype
MGI:5582492
cn14
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• mice reach adulthood without showing inflammatory skin lesions




Genotype
MGI:6241529
cn15
Allelic
Composition
Resttm1.1Yasu/Rest+
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (95 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• mice never form white spots




Genotype
MGI:6241532
cn16
Allelic
Composition
Resttm1.1Yasu/Resttm1.1Yasu
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (95 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• mice never form white spots




Genotype
MGI:5582488
cn17
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1atm2Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks
• milder at P7 than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• skin lesions progressively develop to severe skin inflammation by 4 weeks

immune system
• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks




Genotype
MGI:3714173
cn18
Allelic
Composition
Chuktm1Mpa/Chuktm1Mpa
Tg(KRT14-cre)1Cgn/?
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Mpa mutation (0 available); any Chuk mutation (48 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups die within a few hours of birth

homeostasis/metabolism
• free fatty acids and ceramide content are decreased in the outer layer of the epidermis
• skin on the limbs, tail and parts of the head show increased permeability
• however, skin on the body does not show increased permeability
• cholesterol levels are mildly increased in the outer layer of the epidermis

growth/size/body
• mice loose as much as 5% of their weight within 3 hours of birth

skeleton
N
• in contrast to Chuktm1.1Mpa homozygotes, mice do not have any skeletal abnormalities

integument
• skin on the limbs, tail and parts of the head show increased permeability
• however, skin on the body does not show increased permeability
• epidermis had increased vascularisation
• blood vessel diameter is increased within the epidermis
• primary keratinocytes do not differentiate in medium with increased calcium
• however, keratinocytes differentiate normally in vivo
• free fatty acids and ceramide content are decreased in the outer layer of the epidermis
• lipid composition within the stratum corneum is altered resulting in defective epidermal barrier and increased transepidermal water loss
• at birth skin is shiny, sticky and taut

cellular
• primary keratinocytes do not differentiate in medium with increased calcium
• however, keratinocytes differentiate normally in vivo




Genotype
MGI:7256600
cn19
Allelic
Composition
Otulinem1Gvl/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulinem1Gvl mutation (0 available); any Otulin mutation (22 available)
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• delineated inflamed skin lesions on back

integument
• delineated inflamed skin lesions on back
• delineated inflamed skin lesions on back

neoplasm
• verrucous carcinomas on back skin




Genotype
MGI:5812300
cn20
Allelic
Composition
Snap29tm1c(EUCOMM)Wtsi/Snap29tm1c(EUCOMM)Wtsi
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * DBA/2
Cell Lines EPD0065_4_B10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap29tm1c(EUCOMM)Wtsi mutation (0 available); any Snap29 mutation (28 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups die within a few hours after birth

growth/size/body
• slightly reduced body size

behavior/neurological
• none of the pups contain milk in their stomachs

cellular
• marker analysis indicates disturbed epidermal differentiation of the epidermis

homeostasis/metabolism
• newborns show severe functional impairment of the epidermal barrier

integument
• reduction of hair follicles down to 81% that of wild-type mice
• skin shows decreased deposition of neutral lipids and glucosylceramide in the epidermis
• marker analysis indicates disturbed epidermal differentiation of the epidermis
• corneocytes appear inhomogeneously filled with remnants of nondegraded organelles and electron-lucent vesicle-like structures compared to homogenously filled wild-type corneocytes
• stratum corneum is thickened and its structure is condensed
• the basket-like structure of the stratum granulosum is condensed in the epidermis
• reduction of lamellar body contents in the epidermis
• diminished formation, maturation, and secretion of lamellar bodies
• the number of profilaggrin containing keratohyalin granules in the upper stratum granulosum is decreased in the epidermis
• mice exhibit a congenital ichtyotic phenotype
• skin is taut
• marker analysis indicates disturbed epidermal differentiation of the epidermis
• newborns show severe functional impairment of the epidermal barrier

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
CEDNIK syndrome DOID:0060337 OMIM:609528
J:236759




Genotype
MGI:7256619
cn21
Allelic
Composition
Faddtm1Mpa/Faddtm1Mpa
Mlkltm1.1Wsa/Mlkltm1.1Wsa
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Mpa mutation (0 available); any Fadd mutation (18 available)
Mlkltm1.1Wsa mutation (0 available); any Mlkl mutation (32 available)
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal circulating inflammatory cytokine levels

integument
N
• no skin lesions and normal epidermal thickness




Genotype
MGI:7256622
cn22
Allelic
Composition
Mlkltm1.1Wsa/Mlkltm1.1Wsa
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlkltm1.1Wsa mutation (0 available); any Mlkl mutation (32 available)
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• delineated inflamed skin lesions on back
• no skin lesions in tail

integument
N
• no skin lesions and normal epidermal thickness in tail
• delineated inflamed skin lesions on back
• no skin lesions in tail




Genotype
MGI:7256626
cn23
Allelic
Composition
Otulintm1c(EUCOMM)Hmgu/Otulintm1c(EUCOMM)Hmgu
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulintm1c(EUCOMM)Hmgu mutation (0 available); any Otulin mutation (22 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• increased hair follicle stem cell (HFSC) and interfollicular epidermis (IFE) cell apoptosis
• in both skin lesions and non-lesional skin at age 7 weeks
• hyperproliferation
• accelerated wound closure at day 2 and 4 post-wounding
• decelerated wound closure at day 8 post-wounding
• hypersebacea at age 7 weeks
• at wound sites after completion of re-epithelialization
• of back and tail skin lesions at age 7 weeks
• normal in non-lesional skin
• delineated inflamed skin lesions on back and tail from age P6 onwards
• infiltration of immune cells into lesional skin
• of back and tail skin lesions at age 7 weeks
• normal epidermal thickness of non-lesional skin
• tumor-like lesions at wound sites after completion of re-epithelialization
• delineated inflamed skin lesions on back and tail from age P6 onwards
• verrucous carcinoma developed from back and tail skin lesions

neoplasm
• verrucous carcinoma developed from back and tail skin lesions

immune system
• delineated inflamed skin lesions on back and tail from age P6 onwards
• infiltration of immune cells into lesional skin

cellular
• increased hair follicle stem cell (HFSC) and interfollicular epidermis (IFE) cell apoptosis
• in both skin lesions and non-lesional skin at age 7 weeks
• hyperproliferation
• accelerated wound closure at day 2 and 4 post-wounding
• decelerated wound closure at day 8 post-wounding

endocrine/exocrine glands
• hypersebacea at age 7 weeks

homeostasis/metabolism
• of back and tail skin lesions at age 7 weeks
• normal in non-lesional skin

growth/size/body
• at wound sites after completion of re-epithelialization

embryo
N
• born at normal Mendelian ratios




Genotype
MGI:5582486
cn24
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Il22ra1tm1Rsab/Il22ra1tm1Rsab
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Il22ra1tm1Rsab mutation (0 available); any Il22ra1 mutation (30 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive to adulthood

integument
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks
• at P8, milder than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn

immune system
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks




Genotype
MGI:5582485
cn25
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Il20ratm1Rsab/Il20ratm1Rsab
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Il20ratm1Rsab mutation (0 available); any Il20ra mutation (30 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• severe inflammation requiring euthanasia by P25 in some mice

integument
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn

immune system
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn




Genotype
MGI:6479658
cn26
Allelic
Composition
Trim16tm1Gmma/Trim16+
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Cgn mutation (2 available)
Trim16tm1Gmma mutation (0 available); any Trim16 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice show increased incidence of DMBA and TPA-induced papillomas compared to wild-type mice and homozygotes
• 3 of 30 DMBA and TPA treated mice develop squamous cell carcinomas which are not seen in treated controls
• DMBA and TPA treated mice show an increase in the number of melanomas at 15 weeks compared to wild-type, with mice developing both small and large melanoma lesions after 21 weeks of TPA treatment compared to only small lesions in wild-type mice
• 6 of 33 DMBA/TPA-treated mice show pigmentation in a number of inguinal lymph nodes, suggesting metastatic melanoma
• DMBA and TPA treated mice show an increase in the development of papillomas at 13 and 15 weeks, but not weeks 18 and 21, indicating a decrease in latency of papilloma development

homeostasis/metabolism
• mice show increased incidence of DMBA and TPA-induced papillomas compared to wild-type mice and homozygotes
• 3 of 30 DMBA and TPA treated mice develop squamous cell carcinomas which are not seen in treated controls
• DMBA and TPA treated mice show an increase in the number of melanomas at 15 weeks compared to wild-type, with mice developing both small and large melanoma lesions after 21 weeks of TPA treatment compared to only small lesions in wild-type mice




Genotype
MGI:5582490
cn27
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• psoriasis-like skin inflammation
• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes
• psoriasis-like skin inflammation

immune system
• psoriasis-like skin inflammation
• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes




Genotype
MGI:5582491
cn28
Allelic
Composition
Ikbkbtm1Cgn/Ikbkbtm1Cgn
Il22tm1Jcrd/Il22tm1Jcrd
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Il22tm1Jcrd mutation (0 available); any Il22 mutation (27 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

integument
• severe

immune system




Genotype
MGI:6479659
cn29
Allelic
Composition
Trim16tm1Gmma/Trim16tm1Gmma
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Cgn mutation (2 available)
Trim16tm1Gmma mutation (0 available); any Trim16 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice show similar development of DMBA and TPA-induced papillomas as wild-type mice, with no development of squamous cell carcinoma
• mice show a similar incidence of DMBA/TPA-induced cutaneous melanomas as wild-type mice
• DMBA and TPA treated mice develop larger melanoma lesions than wild-type mice after 21 weeks of TPA treatment

behavior/neurological
N
• mice exhibit normal food consumption




Genotype
MGI:5538741
cn30
Allelic
Composition
Dbitm2.1Smdp/Dbitm2.2Smdp
Tg(KRT14-cre)1Cgn/0
Genetic
Background
involves: C57BL/6 * DBA/2 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbitm2.1Smdp mutation (0 available); any Dbi mutation (23 available)
Dbitm2.2Smdp mutation (0 available); any Dbi mutation (23 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• compromised epidermal barrier function at postnatal day 21
• greasy and tousled appearance identical to that in homozygous germ line null mice

adipose tissue
• elevated lypolysis in isolated inguinal WAT

homeostasis/metabolism
• compromised epidermal barrier function at postnatal day 21
• greater accumulation of cholesteryl esters at P21
• accumulation is less than in homozygous germ line null mice

liver/biliary system
• greater accumulation of cholesteryl esters at P21
• accumulation is less than in homozygous germ line null mice
• expression analysis in fostered pups indicates a defect in liver adaptation to weaning





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory