Analysis Tools
nervous system
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• CCK-8-treated mice fail to exhibit a change in AMPA excitatory postsynaptic currents unlike in similarly treated wild-type mice
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Allele Symbol Allele Name Allele ID |
Plcb1tm1Hssh targeted mutation 1, Hee-Sup Shin MGI:2652485 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CCK-8-treated mice fail to exhibit a change in AMPA excitatory postsynaptic currents unlike in similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in a Morris water maze, standard housed and environmentally enriched mice fail to exhibit a preference for the target quadrant unlike similarly treated wild-type mice
• in a Morris water maze, standard housed exhibit decreased frequency of crossing over the platform and increased latency compared with wild-type mice
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• mice in standard housing exhibit decreased startle reflex compared with wild-type mice in standard housing
• environmental enrichment fails to decrease startle reflex as in similarly treated wild-type mice
• however, clozapine attenuates startle reflex as in wild-type mice
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• mice in standard housing exhibit hyperactivity compared with wild-type mice in standard housing
• however, mice exposed to environmental enrichment exhibit normal activity levels
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• mice in standard housing exhibit decreased prepulse inhibition compared with wild-type mice in standard housing
• however, environmental enrichment or treatment with clozapine rescue prepulse inhibition deficit
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| schizophrenia | DOID:5419 |
OMIM:181500 |
J:151070 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice died at the age of 3 weeks
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• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)
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• exhibited prior to 3 wks of age
• tonic-clonic or tonic extension of the whole body
• putatively evoked by hippocampal hyperexcitability
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• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)
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• exhibited prior to 3 wks of age
• tonic-clonic or tonic extension of the whole body
• putatively evoked by hippocampal hyperexcitability
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• loss of somatostatin-containing neurons, putatively resulting in hippocampal hyperexcitability leading to seizures
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:43077 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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