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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plcb1tm1Hssh
targeted mutation 1, Hee-Sup Shin
MGI:2652485
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plcb1tm1Hssh/Plcb1tm1Hssh involves: 129 * C57BL/6J MGI:4821148
hm2
Plcb1tm1Hssh/Plcb1tm1Hssh involves: 129/Sv * C57BL/6 MGI:4353812
hm3
Plcb1tm1Hssh/Plcb1tm1Hssh Not Specified MGI:2652553


Genotype
MGI:4821148
hm1
Allelic
Composition
Plcb1tm1Hssh/Plcb1tm1Hssh
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb1tm1Hssh mutation (0 available); any Plcb1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• CCK-8-treated mice fail to exhibit a change in AMPA excitatory postsynaptic currents unlike in similarly treated wild-type mice




Genotype
MGI:4353812
hm2
Allelic
Composition
Plcb1tm1Hssh/Plcb1tm1Hssh
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb1tm1Hssh mutation (0 available); any Plcb1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a Morris water maze, standard housed and environmentally enriched mice fail to exhibit a preference for the target quadrant unlike similarly treated wild-type mice
• in a Morris water maze, standard housed exhibit decreased frequency of crossing over the platform and increased latency compared with wild-type mice
• mice in standard housing exhibit decreased startle reflex compared with wild-type mice in standard housing
• environmental enrichment fails to decrease startle reflex as in similarly treated wild-type mice
• however, clozapine attenuates startle reflex as in wild-type mice
• mice in standard housing exhibit hypoactivity compared with wild-type mice in standard housing
• however, mice exposed to environmental enrichment exhibit normal activity levels

nervous system
• mice in standard housing exhibit decreased prepulse inhibition compared with wild-type mice in standard housing
• however, environmental enrichment or treatment with clozapine rescue prepulse inhibition deficit

Mouse Models of Human Disease
OMIM ID Ref(s)
Schizophrenia; SCZD 181500 J:151070




Genotype
MGI:2652553
hm3
Allelic
Composition
Plcb1tm1Hssh/Plcb1tm1Hssh
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plcb1tm1Hssh mutation (0 available); any Plcb1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice died at the age of 3 weeks

behavior/neurological
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)
• exhibited prior to 3 wks of age
• tonic-clonic or tonic extension of the whole body
• putatively evoked by hippocampal hyperexcitability

growth/size/body

nervous system
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)
• exhibited prior to 3 wks of age
• tonic-clonic or tonic extension of the whole body
• putatively evoked by hippocampal hyperexcitability
• loss of somatostatin-containing neurons, putatively resulting in hippocampal hyperexcitability leading to seizures

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:43077





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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory