Mouse Genome Informatics
hm1
    Plcb1tm1Hssh/Plcb1tm1Hssh
involves: 129 * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• CCK-8-treated mice fail to exhibit a change in AMPA excitatory postsynaptic currents unlike in similarly treated wild-type mice


Mouse Genome Informatics
hm2
    Plcb1tm1Hssh/Plcb1tm1Hssh
involves: 129/Sv * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• in a Morris water maze, standard housed and environmentally enriched mice fail to exhibit a preference for the target quadrant unlike similarly treated wild-type mice
• in a Morris water maze, standard housed exhibit decreased frequency of crossing over the platform and increased latency compared with wild-type mice
• mice in standard housing exhibit decreased startle reflex compared with wild-type mice in standard housing
• environmental enrichment fails to decrease startle reflex as in similarly treated wild-type mice
• however, clozapine attenuates startle reflex as in wild-type mice
• mice in standard housing exhibit hypoactivity compared with wild-type mice in standard housing
• however, mice exposed to environmental enrichment exhibit normal activity levels

nervous system
• mice in standard housing exhibit decreased prepulse inhibition compared with wild-type mice in standard housing
• however, environmental enrichment or treatment with clozapine rescue prepulse inhibition deficit

Mouse Models of Human Disease
OMIM IDRef(s)
Schizophrenia; SCZD 181500 J:151070


Mouse Genome Informatics
hm3
    Plcb1tm1Hssh/Plcb1tm1Hssh
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most mice died at the age of 3 weeks

behavior/neurological
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)
• exhibited prior to 3 wks of age
• tonic-clonic or tonic extension of the whole body
• putatively evoked by hippocampal hyperexcitability

growth/size/body

nervous system
• hypersensitivity to epileptogenic drugs (metrazol and kainic acid)
• exhibited prior to 3 wks of age
• tonic-clonic or tonic extension of the whole body
• putatively evoked by hippocampal hyperexcitability
• loss of somatostatin-containing neurons, putatively resulting in hippocampal hyperexcitability leading to seizures

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:43077