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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nr3c1tm1Ljm
targeted mutation 1, Louis J Muglia
MGI:2651864
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nr3c1tm1Ljm/Nr3c1tm1Ljm involves: 129S6/SvEvTac * C57BL/6 MGI:2651865


Genotype
MGI:2651865
hm1
Allelic
Composition
Nr3c1tm1Ljm/Nr3c1tm1Ljm
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm1Ljm mutation (0 available); any Nr3c1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mutants die shortly after birth of respiratory failure (J:81588)
• die within 24 hours of birth (J:82174)

immune system
• thymocytes develop normally in vivo, however thymocytes reconstituted into lethally irradiated wild-type mice are resistant to dexamethasone (DEX)-induced apoptosis
• thymocytes are more resistant than wild-type to anti-CD3epsilon-mediated thymocyte apoptosis in vivo due to lack of the prolonged peripheral glucocorticoid surge

respiratory system
• lung hypercellularity
• poor air space formation

hematopoietic system
• thymocytes develop normally in vivo, however thymocytes reconstituted into lethally irradiated wild-type mice are resistant to dexamethasone (DEX)-induced apoptosis
• thymocytes are more resistant than wild-type to anti-CD3epsilon-mediated thymocyte apoptosis in vivo due to lack of the prolonged peripheral glucocorticoid surge

cellular
• thymocytes develop normally in vivo, however thymocytes reconstituted into lethally irradiated wild-type mice are resistant to dexamethasone (DEX)-induced apoptosis
• thymocytes are more resistant than wild-type to anti-CD3epsilon-mediated thymocyte apoptosis in vivo due to lack of the prolonged peripheral glucocorticoid surge

endocrine/exocrine glands
• thymocytes develop normally in vivo, however thymocytes reconstituted into lethally irradiated wild-type mice are resistant to dexamethasone (DEX)-induced apoptosis
• thymocytes are more resistant than wild-type to anti-CD3epsilon-mediated thymocyte apoptosis in vivo due to lack of the prolonged peripheral glucocorticoid surge





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory