endocrine/exocrine glands
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• enlarged islets of Langerhans in the pancreas was noted in two animals
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growth/size
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• mice are visibly obese by 12 weeks of age; in all litters +/- 50% of the mice exceeded the B6 female database mean weight by 2 S.D and +/- 25% of the mice exceeded the B6 male database mean weight by 2 S.D
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liver/biliary system
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• mild fatty changes in liver were noted at 120 days of age; progressive with age up to 299-370 days of age
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