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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ppargtm2Rev
targeted mutation 2, Ronald M Evans
MGI:2651605
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ppargtm2Rev/Ppargtm2Rev
Tg(Camk2a-cre)62Jzt/?
B6.Cg-Ppargtm2Rev Tg(Camk2a-cre)62Jzt MGI:5444199
cn2
Ppargtm2Rev/Ppargtm2Rev
Tg(Tek-cre)12Flv/?
B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv MGI:5444197
cn3
Ppargtm2Rev/Ppargtm2Rev
Tg(Fabp4-cre)1Rev/0
involves: 129S4/SvJae * C57BL/6 MGI:3033749
cn4
Ppargtm2Rev/Ppargtm2Rev
Tg(Cd4-cre)1Cwi/?
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5444196
cn5
Ppargtm2Rev/Ppargtm2Rev
Tg(Tek-cre)1Ywa/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:5444193
cn6
Ppargtm2Rev/Ppargtm2Rev
Tg(Krt1-15-cre/PGR*)22Cot/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:5444195
cn7
Ppargtm2Rev/Ppargtm2Rev
Tg(Lhb-cre)1Sac/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:5444194
cn8
Ppargtm2Rev/Ppargtm2Rev
Tg(Tagln-cre)1Her/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:5444198
cn9
Ppargtm2Rev/Ppargtm2Rev
Tg(Ucp1-cre)1Evdr/0
involves: 129S4/SvJae * FVB MGI:6361694


Genotype
MGI:5444199
cn1
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Camk2a-cre)62Jzt/?
Genetic
Background
B6.Cg-Ppargtm2Rev Tg(Camk2a-cre)62Jzt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Camk2a-cre)62Jzt mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• gross brain structures are normal and overall appearance is normal
• neurons in culture suffer more severe damage from oxygen-glucose deprivation than controls
• more susceptible to H2O2 induced injury than controls
• develop 40% larger infarctions after middle cerebral artery occlusion
• increased neurological dysfunction as well
• mortality not affected

growth/size/body
N
• growth and body weight are normal

homeostasis/metabolism
N
• normal body temperature

behavior/neurological
N
• activity is normal




Genotype
MGI:5444197
cn2
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Tek-cre)12Flv/?
Genetic
Background
B6.Cg-Ppargtm2Rev Tg(Tek-cre)12Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• about 5% less than controls

immune system

hematopoietic system
• slightly reduced hematocrit

cardiovascular system
• higher baseline pressure
• greater increase when challenged with angiotensin II
• reduced NO production in blood vessel endothelium
• impaired endothelium dependent acetylcholine mediated relaxation of aortic rings

muscle
• impaired endothelium dependent acetylcholine mediated relaxation of aortic rings
• impaired endothelium dependent acetylcholine mediated relaxation of aortic rings




Genotype
MGI:3033749
cn3
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Fabp4-cre)1Rev/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Fabp4-cre)1Rev mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• cell loss greater than 80%
• vacuole form sometimes like white adipose cells rather than typical brown fat cells
• brown adipose tissue mass reduced more than 70% by 6 months of age
• cell numbers reduced more than 95%
• cells are larger and variable in size
• more than 50% of white adipocytes are highly hypertrophic
• diminution of interscapular fat pads detectable by 4-6 weeks

growth/size/body
• weight gain on a high fat diet is decreased
• hepatomegaly eventually develops as well

homeostasis/metabolism
• insulin levels are increased
• insulin became less efficient at suppressing glucose production

liver/biliary system
• hepatomegaly eventually develops as well
• livers were beginning to be steatotic at 6 months of age




Genotype
MGI:5444196
cn4
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Cd4-cre)1Cwi/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased
• accumulate in the CNS rather than the spleen in experimental autoimmune encephalitis
• earlier onset and aggravated disease course during the T-cell dependent phase
• difference from controls disappears after 15 days
• increased number of CD4+ T cells at the beginning of clinical disease (day 8) and at the disease peak (day 13) but not at day 18
• three fold increase in myelin oligodendrocyte glycoprotein specific T cells at disease peak

hematopoietic system
• increased
• accumulate in the CNS rather than the spleen in experimental autoimmune encephalitis




Genotype
MGI:5444193
cn5
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Tek-cre)1Ywa/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Tek-cre)1Ywa mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increased in normal air but similar to controls when both are under hypoxia
• low body weight at weaning strictly dependent on maternal genotype
• body weight is normal in the first post natal week
• weight gain ceases completely at 10 days of age and does not resume until after weaning
• spleen to body weight ratio increases 1.4-2 fold in adults and in 5 and 18 day old pups

integument
• leukocyte infiltration around follicles between 20 and 32 days
• macrophage accumulate in the skin starting at 10 days
• fewer lobular alveolar structures in female mammary glands at day 4 of lactation
• more and larger adipocytes in female mammary glands at day 4 of lactation
• near complete hair loss on the trunk strictly dependent on maternal genotype
• fostering on wild-type mothers corrects hair loss
• hair loss begins around 16 days of age and is complete on the trunk at about 18 days
• new hair growth begins 2-3 weeks after weaning and coat remains normal thereafter
• formation of follicular cysts leading to shaft ejection at 20 days
• new anagen phase does not begin until around 32 days
• formation of follicular cysts leading to shaft ejection at 20 days

liver/biliary system
• pale liver with increased lipid accumulation

cardiovascular system
• increased number of muscularized distal pulmonary arteries
• increased in normal air but similar to controls when both are under hypoxia
• increased in normal air but similar to controls when both are under hypoxia
• less complete recovery from hypoxia than controls 4 weeks after return to normal air

homeostasis/metabolism
• higher triglyceride levels
• higher triglyceride/HDL

skeleton
• irregular, uneven bone structure
• fail to produce osteoclasts in response to rosiglitazone treatment
• no increase in osteoclast numbers
• fewer osteoclasts in femur sections while osteoblast numbers are unchanged
• decreased medullary cavity space
• 30-70% increase
• bone volume/tissue volume ratio is 40-70% higher than controls in both the proximal and distal regions of the femur and tibia
• increased bone volume
• decreased trabecular separation (J:130475)
• no loss of trabecular bone after rosiglitazone treatment as occurs in controls (J:160910)

hematopoietic system
N
• white blood cell, red blood cell, and platelet counts remain normal
• 35% decrease in cellularity
• both erythroid and granulocytic/monocytic
• hematopoietic stem cells reduced 56%
• fail to produce osteoclasts in response to rosiglitazone treatment
• no increase in osteoclast numbers
• fewer osteoclasts in femur sections while osteoblast numbers are unchanged
• spleen to body weight ratio increases 1.4-2 fold in adults and in 5 and 18 day old pups
• accumulation of megakaryocytes in the spleen
• 63% increase in spleen cellularity
• both erythroid and granulocytic/monocytic
• hematopoietic stem cells increased 275%

immune system
• fail to produce osteoclasts in response to rosiglitazone treatment
• no increase in osteoclast numbers
• fewer osteoclasts in femur sections while osteoblast numbers are unchanged
• spleen to body weight ratio increases 1.4-2 fold in adults and in 5 and 18 day old pups
• accumulation of megakaryocytes in the spleen
• 63% increase in spleen cellularity
• both erythroid and granulocytic/monocytic
• hematopoietic stem cells increased 275%
• leukocyte infiltration around follicles between 20 and 32 days
• macrophage accumulate in the skin starting at 10 days

cellular
• fail to produce osteoclasts in response to rosiglitazone treatment
• no increase in osteoclast numbers

endocrine/exocrine glands
• fewer lobular alveolar structures in female mammary glands at day 4 of lactation
• more and larger adipocytes in female mammary glands at day 4 of lactation

muscle
• increased in normal air but similar to controls when both are under hypoxia




Genotype
MGI:5444195
cn6
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Krt1-15-cre/PGR*)22Cot/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• increased interstitial inflammation
• starting around 3 months and associated with increased hair loss
• remaining hair becomes matted
• dystrophic hair follicles
• strands of fibrous connective tissue run perpendicular to the epidermis from dystrophic hair follicles
• follicular ostia are dilated and plugged
• sometimes dystrophic and contiguous with follicular plugs
• becomes flaky and crusty
• mild
• perifollicular fibrosis

behavior/neurological
• associated with progressive hair loss

immune system
• increased interstitial inflammation

endocrine/exocrine glands
• sometimes dystrophic and contiguous with follicular plugs




Genotype
MGI:5444194
cn7
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Lhb-cre)1Sac/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Lhb-cre)1Sac mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• both males and females are fertile and produce litters at a normal rate
• estrus patterns are normal
• diestrus levels of LH are elevated 3-fold

homeostasis/metabolism
• plasma levels are slightly but significantly reduced in males whereas levels are normal in females
• diestrus levels are elevated 3-fold in females whereas male levels are normal




Genotype
MGI:5444198
cn8
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Tagln-cre)1Her/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increased muscularization of pulmonary arteries at the alveolar wall
• elevated right ventricular systolic pressure

growth/size/body

muscle




Genotype
MGI:6361694
cn9
Allelic
Composition
Ppargtm2Rev/Ppargtm2Rev
Tg(Ucp1-cre)1Evdr/0
Genetic
Background
involves: 129S4/SvJae * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm2Rev mutation (1 available); any Pparg mutation (39 available)
Tg(Ucp1-cre)1Evdr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• composed of unilocular adipocytes and fibrotic tissues unlike in controls

homeostasis/metabolism
• following cold exposure, mice fail to exhibit a decrease in branched-chains amino acid plasma concentration unlike in control mice





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory