growth/size/body
|
• increased in normal air but similar to controls when both are under hypoxia
|
|
• low body weight at weaning strictly dependent on maternal genotype
• body weight is normal in the first post natal week
• weight gain ceases completely at 10 days of age and does not resume until after weaning
|
|
• spleen to body weight ratio increases 1.4-2 fold in adults and in 5 and 18 day old pups
|
integument
|
• leukocyte infiltration around follicles between 20 and 32 days
• macrophage accumulate in the skin starting at 10 days
|
|
• fewer lobular alveolar structures in female mammary glands at day 4 of lactation
• more and larger adipocytes in female mammary glands at day 4 of lactation
|
|
• near complete hair loss on the trunk strictly dependent on maternal genotype
• fostering on wild-type mothers corrects hair loss
• hair loss begins around 16 days of age and is complete on the trunk at about 18 days
• new hair growth begins 2-3 weeks after weaning and coat remains normal thereafter
|
|
• formation of follicular cysts leading to shaft ejection at 20 days
|
|
• new anagen phase does not begin until around 32 days
|
|
• formation of follicular cysts leading to shaft ejection at 20 days
|
liver/biliary system
|
• pale liver with increased lipid accumulation
|
cardiovascular system
|
• increased number of muscularized distal pulmonary arteries
|
|
• increased in normal air but similar to controls when both are under hypoxia
|
|
• increased in normal air but similar to controls when both are under hypoxia
• less complete recovery from hypoxia than controls 4 weeks after return to normal air
|
homeostasis/metabolism
skeleton
|
• irregular, uneven bone structure
|
|
• fail to produce osteoclasts in response to rosiglitazone treatment
• no increase in osteoclast numbers
|
|
• fewer osteoclasts in femur sections while osteoblast numbers are unchanged
|
|
• decreased medullary cavity space
|
|
• bone volume/tissue volume ratio is 40-70% higher than controls in both the proximal and distal regions of the femur and tibia
• increased bone volume
|
|
• decreased trabecular separation
(J:130475)
• no loss of trabecular bone after rosiglitazone treatment as occurs in controls
(J:160910)
|
hematopoietic system
N |
• white blood cell, red blood cell, and platelet counts remain normal
|
|
• 35% decrease in cellularity
• both erythroid and granulocytic/monocytic
• hematopoietic stem cells reduced 56%
|
|
• fail to produce osteoclasts in response to rosiglitazone treatment
• no increase in osteoclast numbers
|
|
• fewer osteoclasts in femur sections while osteoblast numbers are unchanged
|
|
• spleen to body weight ratio increases 1.4-2 fold in adults and in 5 and 18 day old pups
|
|
• accumulation of megakaryocytes in the spleen
|
|
• 63% increase in spleen cellularity
• both erythroid and granulocytic/monocytic
• hematopoietic stem cells increased 275%
|
immune system
|
• fail to produce osteoclasts in response to rosiglitazone treatment
• no increase in osteoclast numbers
|
|
• fewer osteoclasts in femur sections while osteoblast numbers are unchanged
|
|
• spleen to body weight ratio increases 1.4-2 fold in adults and in 5 and 18 day old pups
|
|
• accumulation of megakaryocytes in the spleen
|
|
• 63% increase in spleen cellularity
• both erythroid and granulocytic/monocytic
• hematopoietic stem cells increased 275%
|
|
• leukocyte infiltration around follicles between 20 and 32 days
• macrophage accumulate in the skin starting at 10 days
|
cellular
|
• fail to produce osteoclasts in response to rosiglitazone treatment
• no increase in osteoclast numbers
|
endocrine/exocrine glands
|
• fewer lobular alveolar structures in female mammary glands at day 4 of lactation
• more and larger adipocytes in female mammary glands at day 4 of lactation
|
muscle
|
• increased in normal air but similar to controls when both are under hypoxia
|