Mouse Genome Informatics
hm1
    Tectm1Welm/Tectm1Welm
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects
• no alterations in aggregation in response to ADP

immune system
N
• no developmental alterations in T or B cell populations (J:66080)
• number of splenic T and B cells similar to littermate controls (J:66080)
• B cell activation by either anti-IgM Ab or LPS was similar to that of B cells from littermate controls (J:66080)

homeostasis/metabolism
• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects
• no alterations in aggregation in response to ADP


Mouse Genome Informatics
cx2
    Btktm1Wk/Btktm1Wk
Tectm1Welm/Tectm1Welm

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• accumulation of CD43+ B cell precursors, indicating partial developmental block (J:66080)
• partial block at large pre-B cell stage (J:66080)
• attenuated response to LPS (J:66080)
• failure to respond to IgM (J:66080)
• reduced platelet spreading on collagen, but not fibrinogen, monolayer (J:86448)
• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen (J:86448)
• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen (J:86448)
• no alterations in aggregation in response to ADP (J:86448)

immune system
• accumulation of CD43+ B cell precursors, indicating partial developmental block (J:66080)
• partial block at large pre-B cell stage (J:66080)
• failure to respond to IgM (J:66080)
• attenuated response to LPS (J:66080)
• failure to respond to thymus-independent antigen (TNP-Ficoll) (J:66080)
• failure to respond to thymus-dependent antigen (TNP-KLH adsorbed on aluminum hydroxide) (J:66080)

homeostasis/metabolism
• reduced platelet spreading on collagen, but not fibrinogen, monolayer (J:86448)
• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen (J:86448)
• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen (J:86448)
• no alterations in aggregation in response to ADP (J:86448)

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:66080