Mouse Genome Informatics
hm1
    Tectm1Welm/Tectm1Welm
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects
• no alterations in aggregation in response to ADP

immune system
N
• no developmental alterations in T or B cell populations
• number of splenic T and B cells similar to littermate controls
• B cell activation by either anti-IgM Ab or LPS was similar to that of B cells from littermate controls

homeostasis/metabolism
• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects
• no alterations in aggregation in response to ADP


Mouse Genome Informatics
cx2
    Btktm1Wk/Btktm1Wk
Tectm1Welm/Tectm1Welm

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• accumulation of CD43+ B cell precursors, indicating partial developmental block
• partial block at large pre-B cell stage
• failure to respond to IgM
• attenuated response to LPS
• reduced platelet spreading on collagen, but not fibrinogen, monolayer
• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen
• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen
• no alterations in aggregation in response to ADP

immune system
• accumulation of CD43+ B cell precursors, indicating partial developmental block
• partial block at large pre-B cell stage
• failure to respond to IgM
• attenuated response to LPS
• failure to respond to thymus-independent antigen (TNP-Ficoll)
• failure to respond to thymus-dependent antigen (TNP-KLH adsorbed on aluminum hydroxide)

homeostasis/metabolism
• reduced platelet spreading on collagen, but not fibrinogen, monolayer
• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen
• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen
• no alterations in aggregation in response to ADP

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:66080