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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tectm1Welm
targeted mutation 1, Wilfred Ellmeier
MGI:2450883
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tectm1Welm/Tectm1Welm involves: 129P2/OlaHsd * C57BL/6 MGI:3028886
cx2
Btktm1Wk/Btktm1Wk
Tectm1Welm/Tectm1Welm
involves: 129P2/OlaHsd * C57BL/6 MGI:3028887


Genotype
MGI:3028886
hm1
Allelic
Composition
Tectm1Welm/Tectm1Welm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tectm1Welm mutation (0 available); any Tec mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects
• no alterations in aggregation in response to ADP

immune system
N
• no developmental alterations in T or B cell populations
• number of splenic T and B cells similar to littermate controls
• B cell activation by either anti-IgM Ab or LPS was similar to that of B cells from littermate controls

homeostasis/metabolism
• minor reduction in aggregation in response to threshold concentrations of collagen-related peptide (CRP) and to collagen; higher doses overcome these effects
• no alterations in aggregation in response to ADP




Genotype
MGI:3028887
cx2
Allelic
Composition
Btktm1Wk/Btktm1Wk
Tectm1Welm/Tectm1Welm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Wk mutation (1 available); any Btk mutation (10 available)
Tectm1Welm mutation (0 available); any Tec mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• partial block at large pre-B cell stage
• accumulation of CD43+ B cell precursors, indicating partial developmental block
• failure to respond to IgM
• attenuated response to LPS
• reduced platelet spreading on collagen, but not fibrinogen, monolayer
• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen
• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen
• no alterations in aggregation in response to ADP

immune system
• partial block at large pre-B cell stage
• accumulation of CD43+ B cell precursors, indicating partial developmental block
• failure to respond to IgM
• attenuated response to LPS
• failure to respond to thymus-independent antigen (TNP-Ficoll)
• failure to respond to thymus-dependent antigen (TNP-KLH adsorbed on aluminum hydroxide)

homeostasis/metabolism
• reduced platelet spreading on collagen, but not fibrinogen, monolayer
• reduced aggregation in response to high concentrations of collagen-related peptide (CRP) and to collagen
• abolished aggregation in response to low concentrations of collagen-related peptide (CRP) and to collagen
• no alterations in aggregation in response to ADP

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:66080





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory