Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbatm1Paz mutation
(2 available);
any
Hba mutation
(10 available)
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mortality/aging
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• death between E14.5 and E16.5: all homozygotes are dead by E16.5
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growth/size/body
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• noticeably smaller than littermates at E14.5
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hematopoietic system
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• presence of large inclusion bodies in red blood cells at E14.5
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• decreased mean cell hemoglobin content
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homeostasis/metabolism
Allelic
Composition |
Hbatm1Paz/Hba+
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Genetic
Background |
involves: 129S7/SvEvBrd |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbatm1Paz mutation
(2 available);
any
Hba mutation
(10 available)
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reproductive system
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• mice exhibit increased corpus cavernosal smooth muscle relaxation in response to nerve stimulation
• however, treatment with an Adora2b antagonist or PEG-ADA reduces priapic activity
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• mice exhibit priapism that is associated with elevated levels of adenosine
• however, treatment with an Adora2b antagonist or PEG-ADA reduces priapic activity
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mortality/aging
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• fewer than expected mice are present at E12.5
• no viable mice are present at E11.5
• mice die between E10.5 and E12.5
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hematopoietic system
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• extreme at E12.5, indicated by pallor and small fetal liver
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• a small population of Ter119+ CD71low fetal liver cells unlike in wild-type mice
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• primitive erythroblasts at E11.5
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• increased nuclear to cytoplasmic ratio, less condensed and granular nucleus and smaller, less basophilic staining cytoplasm
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• severely impaired at E12.5
• mice exhibit a block in differentiation at the proerythroblast/basophilic erythroblast stage in fetal liver erythropoiesis compared with wild-type mice
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liver/biliary system
embryo
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• severely impaired at E12.5
• mice exhibit a block in differentiation at the proerythroblast/basophilic erythroblast stage in fetal liver erythropoiesis compared with wild-type mice
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growth/size/body
integument
hematopoietic system
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• a small population of Ter119+ CD71low fetal liver cells unlike in wild-type mice
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• greater impairment of Ter119+ CD71hi cells than in double homozygotes
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hematopoietic system
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• mice exhibit normal erythroid development
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mortality/aging
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• many pups turn purple and die within a few hours of birth, however, mice that survive live to become adults (reaching at least 7 months of age)
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growth/size/body
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• weight is increased 2-fold as compared to control
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• weight is increased 2-fold as compared to control
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• weight is increased 13-fold as compared to control
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hematopoietic system
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• congested sinusoidal channels are observed in spleen
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• weight is increased 13-fold as compared to control
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• erythrocytes have increased dynamic rigidity
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• average hematocrit levels are 65% of control at 3-7 months of age
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• erythrocytes contain an excess of alpha globin chain synthesis
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• sickle cell shapes are observed at a frequency of 5-10% in oxygenated blood
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• reticulocyte counts are elevated at 3-7 months of age
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• erythrocytes have decreased osmotic fragility
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homeostasis/metabolism
cardiovascular system
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• congested sinusoidal channels are observed in spleen
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• weight is increased 2-fold as compared to control
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renal/urinary system
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• weight is increased 2-fold as compared to control
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• iron deposits found in the tubular epithelium of the kidney
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immune system
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• congested sinusoidal channels are observed in spleen
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• weight is increased 13-fold as compared to control
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liver/biliary system
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• iron deposits found in Kupffer cells of liver
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respiratory system
Analysis Tools