Phenotypes associated with this allele
Allelic
Composition |
Sptbn1tm1Mish/Sptbn1tm1Mish
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Genetic
Background |
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * NIH Black Swiss) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn1tm1Mish mutation
(0 available);
any
Sptbn1 mutation
(139 available)
|
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mortality/aging
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• abnormal or degenerating embryos detected between E8.5 and E16.5
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cardiovascular system
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• lack of branching network of vessels in yolk sac
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• absence of trabeculated pattern of myocardial tissue; myoblasts were hyperplastic and lacked linear arrangement of nuclei
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• small ventricular lumen; occlusion of atrioventricular region
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craniofacial
digestive/alimentary system
embryo
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• lack of branching network of vessels in yolk sac
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• smaller body and head size, evident at E9.5
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growth/size/body
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• smaller body and head size, evident at E9.5
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liver/biliary system
muscle
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• absence of trabeculated pattern of myocardial tissue; myoblasts were hyperplastic and lacked linear arrangement of nuclei
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nervous system
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• abnormal anatomy of primary brain vesicles
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Allelic
Composition |
Sptbn1tm1Mish/Sptbn1+
|
|
Genetic
Background |
involves: 129S6/SvEvTac |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn1tm1Mish mutation
(0 available);
any
Sptbn1 mutation
(139 available)
|
|
|
Beckwith-Wiedemann Syndrome-like phenotypes in Sptbn1tm1Mish/Spnb2+ mice
mortality/aging
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• increase in incidence of sudden death in males
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growth/size/body
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• 25% increase in average body size and mass compared to wild-type
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neoplasm
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• adrenocortical carcinomas
|
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• 3.4% incidence of epithelial tumors in the ovary
|
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• 3.4% incidence of testicular carcinomas
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• 37.9-40% increase in incidence of liver tumors
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• 3.4% incidence of breast adenomas
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• 6.9% incidence of spleen lymphomas
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• pancreatic carcinomas and adrenocortical carcinomas
• 3.4% incidence of testicular carcinomas
|
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• 6.9% incidence of adenocarcinomas in the lung
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• 10.3% incidence of renal cell carcinomas
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• 3.4% incidence of abdominal/mesenchymal sarcomas
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hearing/vestibular/ear
integument
cardiovascular system
craniofacial
digestive/alimentary system
endocrine/exocrine glands
|
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• adrenocortical carcinomas
|
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• 3.4% incidence of epithelial tumors in the ovary
|
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• 3.4% incidence of testicular carcinomas
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liver/biliary system
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• 37.9-40% increase in incidence of liver tumors
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renal/urinary system
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• 10.3% incidence of renal cell carcinomas
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reproductive system
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• 3.4% incidence of epithelial tumors in the ovary
|
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• 3.4% incidence of testicular carcinomas
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respiratory system
|
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• 6.9% incidence of adenocarcinomas in the lung
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nervous system
Allelic
Composition |
Sptbn1tm1Mish/Sptbn1+
|
|
Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sptbn1tm1Mish mutation
(0 available);
any
Sptbn1 mutation
(139 available)
|
|
|
neoplasm
|
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• mice spontaneously develop tumors of the liver with an incidence of 40%
• lesions included early centrilobular steatosis and dysplasia with nuclear disarray and stratification
• many of these lesions progress to poorly differentiated carcinomas
|
liver/biliary system
|
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• apoptosis rates are lower among hepatocytes potentially leading to lesion formation
|
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• mice spontaneously develop tumors of the liver with an incidence of 40%
• lesions included early centrilobular steatosis and dysplasia with nuclear disarray and stratification
• many of these lesions progress to poorly differentiated carcinomas
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cellular
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• apoptosis rates are lower among hepatocytes potentially leading to lesion formation
|
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itih4tm1Mish mutation
(0 available);
any
Itih4 mutation
(60 available)
Sptbn1tm1Mish mutation
(0 available);
any
Sptbn1 mutation
(139 available)
|
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neoplasm
|
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• only 1 mouse in 25 developed a liver neoplasm compared to the 40% incidence rate observed in mice carrying just one null allele for Spnb2
• the lone tumor was about 10-fold smaller than the mean tumor sizes observed in the control mice
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liver/biliary system
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• apoptosis rates are lower in hepatocytes compared to control mice
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• hepatocyte proliferation is lower than in controls
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• only 1 mouse in 25 developed a liver neoplasm compared to the 40% incidence rate observed in mice carrying just one null allele for Spnb2
• the lone tumor was about 10-fold smaller than the mean tumor sizes observed in the control mice
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cellular
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• apoptosis rates are lower in hepatocytes compared to control mice
|
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• hepatocyte proliferation is lower than in controls
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Analysis Tools