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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Commd10Tg(Vav1-icre)A2Kio
transgene insertion A2, Dimitris Kioussis
MGI:2449949
Summary 75 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Adh5tm1.1Llli/Adh5tm1.1Llli
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Adh5tm1.1Llli Commd10Tg(Vav1-icre)A2Kio MGI:5049928
cn2
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio MGI:5525143
cn3
Fbxo21em1Smbk/Fbxo21em1Smbk
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Fbxo21em1Smbk Commd10Tg(Vav1-icre)A2Kio MGI:7444791
cn4
Ly6etm1c(EUCOMM)Hmgu/Ly6etm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Ly6etm1c(EUCOMM)Hmgu Commd10Tg(Vav1-icre)A2Kio MGI:6449004
cn5
Patz1tm1.2Welm/Patz1tm1.2Welm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Patz1tm1.2Welm Commd10Tg(Vav1-icre)A2Kio MGI:5572830
cn6
Pkn3tm1.1Mrl/Pkn3tm1.1Mrl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Pkn3tm1.1Mrl Commd10Tg(Vav1-icre)A2Kio MGI:5688866
cn7
Snai1tm1.1Stjw/Snai1tm1.1Stjw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Snai1tm1.1Stjw Commd10Tg(Vav1-icre)A2Kio MGI:5659610
cn8
Cdkn1atm1Led/Cdkn1atm1Led
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio MGI:5006710
cn9
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zbtb17tm1Cksn Commd10Tg(Vav1-icre)A2Kio MGI:5006709
cn10
Zfp318tm1.1Jhws/Zfp318tm1.1Jhws
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zfp318tm1.1Jhws TgVav1-creA2Kio MGI:5606282
cn11
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio MGI:5558063
cn12
Commd10Tg(Vav1-icre)A2Kio/0
Nfil3tm1.2Kubo/Nfil3tm1.2Kubo
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:7448515
cn13
Plek2tm1Pji/Plek2tm1Pji
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:6356967
cn14
Cd40lgtm1Parl/Cd40lgtm1Parl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:5585442
cn15
Cd40lgtm1Parl/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:5585443
cn16
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:5525153
cn17
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:6356966
cn18
F8tm1.1Rmnt/F8tm1.1Rmnt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL MGI:5582833
cn19
Dhx36tm1.2Pmt/Dhx36tm1.2Pmt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca MGI:5427982
cn20
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:3804186
cn21
Rbpjtm1Hon/Rbpjtm1Hon
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:4821304
cn22
Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:3804204
cn23
Idh1tm1Mak/Idh1tm1Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca MGI:5438277
cn24
Myd88tm1Defr/Myd88tm1Defr
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3809645
cn25
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL * CBA MGI:3804203
cn26
Syktm1.1Nns/Syktm1.1Nns
Tg(Tie1-cre)9Ref/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca MGI:5314235
cn27
Bmi1tm1Sgon/Bmi1tm1Sgon
Commd10Tg(Vav1-icre)A2Kio/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca MGI:5693398
cn28
Lmo4tm1Slp/Lmo4tm1Slp
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca MGI:6385528
cn29
Lmo4tm1Slp/Lmo4tm1Slp
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca MGI:6385529
cn30
Bcortm1.1Vjba/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * CBA/Ca MGI:5925308
cn31
Trp53tm1Tyj/Trp53tm1Tyj
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca MGI:6712734
cn32
Kmt2atm1Brad/Kmt2atm1Brad
Commd10Tg(Vav1-icre)A2Kio/?
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca MGI:3849329
cn33
Rr7tm3.1Kio/Rr7+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca MGI:5305077
cn34
Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca MGI:5490534
cn35
Cdk5rap3tm1c(EUCOMM)Hmgu/Cdk5rap3tm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca MGI:6295912
cn36
Il22tm1.1Lex/Il22tm1.1Lex
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca MGI:6712732
cn37
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640745
cn38
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640746
cn39
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640744
cn40
Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Rptortm1.1Dmsa/Rptor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S/SvEv * C57BL/10 * CBA/Ca MGI:6513971
cn41
Sppl3tm1Itl/Sppl3tm1Itl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S/SvEv * C57BL/6 * C57BL/10 * CBA/Ca MGI:6515779
cn42
Kmt5btm1Jnw/Kmt5btm1Jnw
Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca MGI:3810116
cn43
Kitltm2.1Sjm/Kitltm2.2Sjm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: BALB/cJ * C57BL * CBA/Ca * SJL MGI:5306351
cn44
Commd10Tg(Vav1-icre)A2Kio/0
Map3k7tm1.1Arte/Map3k7tm1.1Arte
involves: C57BL/10 * C57BL/6J * C57BL/6NTac * CBA/Ca MGI:7451043
cn45
Syktm1.1Nns/Syktm1.1Nns
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/10 * CBA/Ca MGI:5314234
cn46
Cdh5tm8Dvst/Cdh5tm8Dvst
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/10 * CBA/Ca MGI:5661695
cn47
Piezo1tm2.1Apat/Piezo1tm2.1Apat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA MGI:5776602
cn48
Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:6513967
cn49
Tg(Kit*D814V)3Roer/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:4942368
cn50
Tg(Kit*D814V)1Roer/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:4942367
cn51
Bcl11atm1Pwt/Bcl11atm1Pwt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5564914
cn52
Tg(JAK2*V617F)FF1Rsko/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5553469
cn53
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:6385521
cn54
Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5496262
cn55
Idh1tm2Mak/Idh1tm2Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5438280
cn56
Gt(ROSA)26Sortm2(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5496264
cn57
Atp6v0a2tm1Kdb/Atp6v0a2tm1Kdb
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:6303639
cn58
Satb1tm2Kos/Satb1tm2Kos
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:7281769
cn59
A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:7311733
cn60
Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Commd10Tg(Vav1-icre)A2Kio/?
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5488604
cn61
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL MGI:5301602
cn62
Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca MGI:6267348
cn63
Zbtb38em1Dbhat/Zbtb38em1Dbhat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca MGI:6696062
cn64
Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca MGI:6267349
cn65
Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca MGI:5902764
cn66
Jagn1tm1c(EUCOMM)Hmgu/Jagn1tm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca MGI:5604905
cn67
Riok2tm1c(KOMP)Wtsi/Riok2tm1c(KOMP)Wtsi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca MGI:6712637
cn68
Il22ra1tm1.1Koll/Il22ra1tm1.1Koll
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca MGI:6712737
cn69
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca MGI:6712638
cn70
Commd10Tg(Vav1-icre)A2Kio/?
Tnfrsf14tm1.1Kro/Tnfrsf14tm1.1Kro
involves: C57BL/6NCrl * C57BL/10 * CBA * SJL MGI:5908557
cn71
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Ociad1tm1Msin/Ociad1tm1Msin
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj MGI:6367554
cn72
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj MGI:5527435
cn73
Atg7tm1Tchi/Atg7tm1Tchi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj MGI:5295638
cx74
Trp53tm1Tyj/Trp53tm1Tyj
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca MGI:6712735
cx75
Il22tm1.1Lex/Il22tm1.1Lex
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca MGI:6712736


Genotype
MGI:5049928
cn1
Allelic
Composition
Adh5tm1.1Llli/Adh5tm1.1Llli
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Adh5tm1.1Llli Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh5tm1.1Llli mutation (0 available); any Adh5 mutation (27 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival following diethylnitrosamine (DEN) challenged




Genotype
MGI:5525143
cn2
Allelic
Composition
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Egln1tm2.1Fsl mutation (0 available); any Egln1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased numbers of BFU-E colonies are observed at both high and low concentrations of erythropoietin
• mice exhibit erythrocytosis, however, erythropoietin levels are not increased
• hematocrits are modestly increased over controls




Genotype
MGI:7444791
cn3
Allelic
Composition
Fbxo21em1Smbk/Fbxo21em1Smbk
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Fbxo21em1Smbk Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Fbxo21em1Smbk mutation (0 available); any Fbxo21 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
• 5-FU-treated mice exhibit increased bone marrow failure and lethality compared with wild-type mice
• in the bone marrow but not peripheral blood
• slightly decreased CFY potential in vitro
• however, steady-state hematopoiesis and performance in competitive repopulation assay are normal

immune system
• in the bone marrow but not peripheral blood




Genotype
MGI:6449004
cn4
Allelic
Composition
Ly6etm1c(EUCOMM)Hmgu/Ly6etm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Ly6etm1c(EUCOMM)Hmgu Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Ly6etm1c(EUCOMM)Hmgu mutation (1 available); any Ly6e mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice infected with a high dose of mouse hepatitis virus-A59 (MHV) rapidly succumb to infection by day 6 compared to 100% survival in controls

immune system
• MHV-infected males show reduced recruitment of neutrophils to the liver and spleen
• MHV-infected males show reduced recruitment of natural killer cells to the liver and spleen
• by 5 days post MHV-infection and at both low and high doses of MHV, females show reduced presence of mononuclear immune cells in the liver
• MHV-infected males and females show reduced hepatic and spleen B cell numbers
• MHV-infected males and females how reduced recruitment of natural killer cells to the liver and spleen
• MHV-infected females show reduced hepatic CD4+ T cells
• MHV-infected males show reduced recruitment of macrophages to the liver
• at 3 days post MHV-infection, inflammation is moderately reduced in females compared to controls, but not in males
• mice are highly susceptible to mouse hepatitis virus-A59 (MHV) with mice infected with a high dose of MHV rapidly succumbing to infection by day 6
• males show greater susceptibility than females
• females and males infected with MHV show elevated spleen viral burden at both high and lower doses of MHV, however hepatic viral burden is similar in males and females
• viral burden and liver damage are elevated in females at a lower dose of MHV but not in males which exhibit saturated hepatic infection
• bone marrow-derived macrophages are more susceptible to MHV infection
• in splenocyte cultures, MHV infects macrophages, neutrophils, dendritic cells and B cells but not CD4+ or CD8+ T cells
• B cells from both male and female mice are highly susceptible to MHV infection
• mice infected with a high dose of mouse hepatitis virus-A59 (MHV) rapidly succumb to infection by day 6 compared to 100% survival in controls

hematopoietic system
• MHV-infected males show reduced recruitment of neutrophils to the liver and spleen
• MHV-infected males show reduced recruitment of natural killer cells to the liver and spleen
• by 5 days post MHV-infection and at both low and high doses of MHV, females show reduced presence of mononuclear immune cells in the liver
• MHV-infected males and females show reduced hepatic and spleen B cell numbers
• MHV-infected males and females how reduced recruitment of natural killer cells to the liver and spleen
• MHV-infected females show reduced hepatic CD4+ T cells
• MHV-infected males show reduced recruitment of macrophages to the liver

homeostasis/metabolism
• females, but not males, infected with MHV exhibit increased serum alanine aminotransferase levels

liver/biliary system
• females, but not males, infected with MHV exhibit higher levels of liver damage than controls
• by 5 days post MHV-infection and at both low and high doses of MHV, females show higher levels of liver necrosis than males
• mice infected with an intermediate viral dose of MHV exhibit liver pallor

cellular
• by 5 days post MHV-infection and at both low and high doses of MHV, females show higher levels of liver necrosis than males




Genotype
MGI:5572830
cn5
Allelic
Composition
Patz1tm1.2Welm/Patz1tm1.2Welm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Patz1tm1.2Welm Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Patz1tm1.2Welm mutation (0 available); any Patz1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice subjected to systemic anaphylaxis exhibit normal histamine release response of mast cells in vivo
• mice exhibit normal cutaneous anaphylaxis response
• bone marrow-derived mast cells exhibit normal early and late effector functions upon Fcer1-mediated activation
• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal
• in bone marrow-derived mast cells activated with TNP

cellular
• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal

hematopoietic system
• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal




Genotype
MGI:5688866
cn6
Allelic
Composition
Pkn3tm1.1Mrl/Pkn3tm1.1Mrl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Pkn3tm1.1Mrl Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Pkn3tm1.1Mrl mutation (0 available); any Pkn3 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• hematopoietic stem cell numbers are similar to controls at 6-8 weeks of age and cells perform similar to control cells in a competitive transplantation assay




Genotype
MGI:5659610
cn7
Allelic
Composition
Snai1tm1.1Stjw/Snai1tm1.1Stjw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Snai1tm1.1Stjw Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Snai1tm1.1Stjw mutation (0 available); any Snai1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable with no gross abnormalities at E14.5, E17.5 and P1
• hematopoietic progenitors from E9.5 embryos demonstrate comparable erythroid colony formation




Genotype
MGI:5006710
cn8
Allelic
Composition
Cdkn1atm1Led/Cdkn1atm1Led
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (60 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• double negative to double positive differentiation is blocked unlike in wild-type mice

hematopoietic system
• double negative to double positive differentiation is blocked unlike in wild-type mice




Genotype
MGI:5006709
cn9
Allelic
Composition
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Zbtb17tm1Cksn Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• pro-T cells exhibit excessive cell death unlike wild-type cells
• 100-fold reduction in cellularity
• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice
• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro
• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells

hematopoietic system
• pro-T cells exhibit excessive cell death unlike wild-type cells
• 100-fold reduction in cellularity
• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice
• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro
• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells

cellular
• pro-T cells exhibit excessive cell death unlike wild-type cells

endocrine/exocrine glands
• 100-fold reduction in cellularity
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells




Genotype
MGI:5606282
cn10
Allelic
Composition
Zfp318tm1.1Jhws/Zfp318tm1.1Jhws
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6.Cg-Zfp318tm1.1Jhws TgVav1-creA2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Zfp318tm1.1Jhws mutation (1 available); any Zfp318 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• slight decrease in splenic T2 B cells in 4 week old mice
• decreased levels of IgD in transitional type 1 and 2 (T1,2), follicular (FO) and marginal zone (MZ) B cell populations
• increased levels of IgM in transitional type 2 (T2), follicular (FO) and marginal zone (MZ) B cell populations

hematopoietic system
• slight decrease in splenic T2 B cells in 4 week old mice
• decreased levels of IgD in transitional type 1 and 2 (T1,2), follicular (FO) and marginal zone (MZ) B cell populations
• increased levels of IgM in transitional type 2 (T2), follicular (FO) and marginal zone (MZ) B cell populations




Genotype
MGI:5558063
cn11
Allelic
Composition
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Ifngr1tm1.1Rds mutation (1 available); any Ifngr1 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

immune system
• mice infected with L. monocytogenes exhibit increased mortality and spleen and liver bacterial counts compared with control mice




Genotype
MGI:7448515
cn12
Allelic
Composition
Commd10Tg(Vav1-icre)A2Kio/0
Nfil3tm1.2Kubo/Nfil3tm1.2Kubo
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Nfil3tm1.2Kubo mutation (0 available); any Nfil3 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• cDC1s virtually absent

immune system
• cDC1s virtually absent




Genotype
MGI:6356967
cn13
Allelic
Composition
Plek2tm1Pji/Plek2tm1Pji
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Jak2tm1.1Ble mutation (1 available); any Jak2 mutation (57 available)
Plek2tm1Pji mutation (0 available); any Plek2 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• more than 80% of mice survive beyond 40 weeks
• mice treated with phenylhydrazine to further reduce red blood counts show an even greater improvement in survival

hematopoietic system
N
• mice exhibit amelioration of the neutrophilia and thrombocytosis, partial reversion of reticulocytosis, mild reduction in red blood cell counts, fewer megakaryocytes and megakaryocyte clusters, reduced spleen size, and reversion of about 25% of the red blood cell expansion seen in single Jak2tm1.1Ble conditional mutants
• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show a reduction in the increased proliferation of erythroid and granulocytic cells seen in single Jak2tm1.1Ble conditional mutants
• granulocytic differentiation to Gr1/Mac1 double-positive cells is mildly decreased in cultured cells
• early-stage megakaryocytic differentiation to CD41+ cells is mildly decreased in cultured cells

homeostasis/metabolism
N
• mice show decreased vascular occlusions than in single Jak2tm1.1Ble conditional mutants, with a decrease in the number of large clots with compact red blood cells and improved blood flow

immune system
N
• several proinflammatory cytokines, including CCL3 and CSF1, that are increased in single Jak2tm1.1Ble conditional mutants are reduced
• granulocytic differentiation to Gr1/Mac1 double-positive cells is mildly decreased in cultured cells

cellular
• erythroid differentiation to Ter119/CD71 double-positive cells is mildly decreased in cultured cells
• granulocytic differentiation to Gr1/Mac1 double-positive cells is mildly decreased in cultured cells
• early-stage megakaryocytic differentiation to CD41+ cells is mildly decreased in cultured cells




Genotype
MGI:5585442
cn14
Allelic
Composition
Cd40lgtm1Parl/Cd40lgtm1Parl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Parl mutation (0 available); any Cd40lg mutation (14 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hemograms
• decreased circulating platelets 2 min after administration of agonists

homeostasis/metabolism
N
• mice exhibit normal prothrombin tine and activated partial thromboplastin time

immune system




Genotype
MGI:5585443
cn15
Allelic
Composition
Cd40lgtm1Parl/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Parl mutation (0 available); any Cd40lg mutation (14 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hemograms
• decreased circulating platelets 2 min after administration of agonists

homeostasis/metabolism
N
• mice exhibit normal prothrombin tine and activated partial thromboplastin time

immune system




Genotype
MGI:5525153
cn16
Allelic
Composition
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Kdm1atm1.1Sho mutation (1 available); any Kdm1a mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• hematopoietic stem and progenitor cell populations are distorted
• 30 fold decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+)
• found in femur and tibia of 5 day old mice as compared to control
• found in peripheral blood of 5 day old mice as compared to control
• found in peripheral blood of 5 day old mice as compared to control
• found in peripheral blood of 5 day old mice as compared to control
• 30 fold decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+)

immune system
• found in peripheral blood of 5 day old mice as compared to control

growth/size/body
• newborn pups are smaller than controls

mortality/aging
• lethality is a result severe anemia
• most mice die by day 10




Genotype
MGI:6356966
cn17
Allelic
Composition
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Jak2tm1.1Ble mutation (1 available); any Jak2 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die around 30 weeks of age
• mice treated with phenylhydrazine to reduce red blood cells without affecting neutrophils show reversion of lethality

hematopoietic system
• however, mice do not develop myelofibrosis
• mice exhibit extramedullary hematopoiesis
• bone marrow stem cell populations show an expansion of the erythroid progenitor population within myeloid progenitor cell
• however, long-term and short-term hematopoietic stem cells and multipotent progenitor compositions are not affected
• bone marrow stem cell populations show an expansion of the megakaryocytic progenitor population within myeloid progenitor cells
• red blood cell mass is roughly tripled by increasing the absolute whole-body red blood cell number
• erythrocytosis
• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of erythroid cells
• leukocytosis, including neutrophilia
• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of granulocytic cells

homeostasis/metabolism
• moribund mice exhibit widespread large vascular occlusions, prominently in the lungs and kidney
• moribund mice often show symptoms of thrombosis, including low extremity paralysis and coolness, tachycardia, and tachypnea
• increase in several proinflammatory cytokines, including CCL3 and CSF1

immune system
• leukocytosis, including neutrophilia
• bone marrow lineage-negative hematopoietic stem and progenitor cells grown in culture show increased proliferation of granulocytic cells
• increase in several proinflammatory cytokines, including CCL3 and CSF1

behavior/neurological
• low extremity paralysis in moribund mice

cardiovascular system
• moribund mice exhibit widespread large vascular occlusions, prominently in the lungs and kidney
• mice treated with repeated injections of Ly-6G antibody to reduce the peripheral neutrophil count do not show alternations in vascular occlusions
• mice treated with phenylhydrazine to reduce red blood cells without affecting neutrophils show a reduction in vascular occlusion formation
• tachycardia in moribund mice

respiratory system
• tachypnea in moribund mice

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myeloproliferative neoplasm DOID:2226 J:257910




Genotype
MGI:5582833
cn18
Allelic
Composition
F8tm1.1Rmnt/F8tm1.1Rmnt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
F8tm1.1Rmnt mutation (1 available); any F8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:5427982
cn19
Allelic
Composition
Dhx36tm1.2Pmt/Dhx36tm1.2Pmt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Dhx36tm1.2Pmt mutation (1 available); any Dhx36 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• without affecting architecture
• in adult mice
• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.B and Ery.C in the bone marrow compared with control mice
• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.C in the spleen compared with control mice
• early erythropoiesis is partially blocked in association with a cell cycle defect
• proerythroblast exhibit reduced proliferation compared with control cells
• however, proerythroblast apoptosis rates are normal
• intrinsic as determined by bone marrow transplantation
• decrease in the granulocyte macrophage progenitor (GMP) cells in the bone marrow
• ProE cells are increased 3.6- and 74-fold in the bone marrow and spleen compared with control mice
• in the bone marrow
• 4.7-fold in the spleen
• secondary
• early long and short term hematopoietic stem cells are increased compared to in control mice
• however, the number of lymphoid-primed multipotent progenitors is normal and the increased in hematopoietic stem cells disappears in the alter stages of differentiation
• increase in the megakaryocyte-erythroid progenitor (MEP) cells in the spleen
• reduced half-life

liver/biliary system
• in adult mice

renal/urinary system

cellular
• proerythroblast exhibit reduced proliferation compared with control cells

integument
• at birth

immune system
• without affecting architecture
• in adult mice

endocrine/exocrine glands
• without affecting architecture

growth/size/body
• in adult mice
• in adult mice




Genotype
MGI:3804186
cn20
Allelic
Composition
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice lack committed c-Kit+CD19+ pro-B cells

immune system
• mice lack committed c-Kit+CD19+ pro-B cells




Genotype
MGI:4821304
cn21
Allelic
Composition
Rbpjtm1Hon/Rbpjtm1Hon
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Rbpjtm1Hon mutation (2 available); any Rbpj mutation (193 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• transplanted bone marrow progenitors transfected with BCR-ABL and NUP98-HOXA9 proliferate slower than similarly treated wild-type cells improving host survival




Genotype
MGI:3804204
cn22
Allelic
Composition
Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Ikzf1tm1.1(Pax5)Mbu mutation (0 available); any Ikzf1 mutation (30 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• development of pro-B cells is rescued
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent

hematopoietic system
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent




Genotype
MGI:5438277
cn23
Allelic
Composition
Idh1tm1Mak/Idh1tm1Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Idh1tm1Mak mutation (0 available); any Idh1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hematopoietical parameters in peripheral blood and normal bone marrow cell numbers
• increase in common lymphocyte progenitor cells in the bone marrow and spleen
• increase in megakaryocyte-erythroid progenitors in the spleen
• increase in LSK and lineage-restricted progenitors in the bone marrow and spleen
• increase in LK in the spleen




Genotype
MGI:3809645
cn24
Allelic
Composition
Myd88tm1Defr/Myd88tm1Defr
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Myd88tm1Defr mutation (3 available); any Myd88 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists
• NK cells in vivo have a blunted IFN-gamma response to LPS injections

hematopoietic system
• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists
• NK cells in vivo have a blunted IFN-gamma response to LPS injections




Genotype
MGI:3804203
cn25
Allelic
Composition
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129P2/OlaHsd * C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (39 available)
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• c-Kit+B220+ pro-B cells and c-Kit-B220+ developmental stages are rescued




Genotype
MGI:5314235
cn26
Allelic
Composition
Syktm1.1Nns/Syktm1.1Nns
Tg(Tie1-cre)9Ref/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Syktm1.1Nns mutation (0 available); any Syk mutation (42 available)
Tg(Tie1-cre)9Ref mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike null homozygotes, mice survive to adulthood

immune system
• at E14.5, mice exhibit blood-filled vessels unlike wild-type mice




Genotype
MGI:5693398
cn27
Allelic
Composition
Bmi1tm1Sgon/Bmi1tm1Sgon
Commd10Tg(Vav1-icre)A2Kio/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1tm1Sgon mutation (0 available); any Bmi1 mutation (33 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• born at the expected frequency and fertile
• 93% die by 24-26 weeks

hematopoietic system
• 4X smaller than controls in older mice
• with loss of cortico-medullary differentiation
• absolute numbers of progenitors reduced 2 fold
• reduced myeloid colony formation
• reduced erythroid colony formation
• cellularity reduced
• hypoplasia in femora
• significant and progressive increase of immunophenotypic common lymphoid fraction
• lymphoid colony frequency is reduced 4X
• increased proportion of cells in S/G2/M phase
• homing of cells to host bone marrow is reduced
• significant loss of B lymphocytes in young mice
• significant loss of T lymphocytes in young mice
• slight decrease in myeloid cells
• in bone marrow
• remaining cells unable to repopulate irradiated hosts
• stem cells fail to maintain quiescence
• 4X smaller than controls in older mice

immune system
• significant loss of B lymphocytes in young mice
• significant loss of T lymphocytes in young mice
• 4X smaller than controls in older mice
• with loss of cortico-medullary differentiation
• 4X smaller than controls in older mice

endocrine/exocrine glands
• 4X smaller than controls in older mice
• with loss of cortico-medullary differentiation




Genotype
MGI:6385528
cn28
Allelic
Composition
Lmo4tm1Slp/Lmo4tm1Slp
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Lmo4tm1Slp mutation (0 available); any Lmo4 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced in the small intestine and liver, ILC2s in the small intestine and lung, and ILC3s in the small intestine
• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)
• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed
• however, normal frequencies of alpha4Beta7+ CLPs are seen
• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection
• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

immune system
• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced in the small intestine and liver, ILC2s in the small intestine and lung, and ILC3s in the small intestine
• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)
• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed
• however, normal frequencies of alpha4Beta7+ CLPs are seen
• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection
• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge
• number of intestinal lymphoid follicles is decreased
• however, NK cells in the spleen and blood are not affected
• number of Peyers patches is decreased
• leukocyte infiltration is attenuated in the lungs after papain challenge
• mice exhibit a higher number of S. typhimurium CFUs in mesenteric lymph nodes after infection than controls
• mice exhibit a higher number of bacterial CFUs in feces, weight loss and shrinking colon length accompanied by more severe intestinal damage after C. rodentium infection




Genotype
MGI:6385529
cn29
Allelic
Composition
Lmo4tm1Slp/Lmo4tm1Slp
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Lmo4tm1Slp mutation (0 available); any Lmo4 mutation (9 available)
Yeats4em1Zfa mutation (0 available); any Yeats4 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mutant alpha4Beta7+ common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)
• differentiation ability of alpha4Beta7+ CLPs in culture is impaired
• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection
• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

immune system
• mutant alpha4Beta7+ common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)
• differentiation ability of alpha4Beta7+ CLPs in culture is impaired
• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection
• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge
• leukocyte infiltration is attenuated in the lungs after papain challenge
• mice exhibit a higher number of S. typhimurium CFUs in mesenteric lymph nodes after infection than controls
• mice exhibit a higher number of bacterial CFUs in feces, weight loss and shrinking colon length accompanied by more severe intestinal damage after C. rodentium infection




Genotype
MGI:5925308
cn30
Allelic
Composition
Bcortm1.1Vjba/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S1/Sv * C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcortm1.1Vjba mutation (1 available); any Bcor mutation (21 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in peripheral blood neutrophil levels
• however, no changes in red blood cell, platelet or lymphocyte levels

immune system
• increase in peripheral blood neutrophil levels
• however, no changes in red blood cell, platelet or lymphocyte levels




Genotype
MGI:6712734
cn31
Allelic
Composition
Trp53tm1Tyj/Trp53tm1Tyj
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Riok2tm1c(KOMP)Wtsi mutation (0 available); any Riok2 mutation (33 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• the increase in IL-22 secretion seen in in vitro polarized TH22 cells in single conditional Riok2 heterozygotes is blunted




Genotype
MGI:3849329
cn32
Allelic
Composition
Kmt2atm1Brad/Kmt2atm1Brad
Commd10Tg(Vav1-icre)A2Kio/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Kmt2atm1Brad mutation (0 available); any Kmt2a mutation (135 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• there is about a 2-fold reduction in myeloid CFU number isolated from E13.5 fetal livers
• a similar reduction in CFU is observed with bone marrow cells
• there is about a 3-fold reduction in pre-B cell CFUs isolated from bone marrow
• mutant HSC bone marrow cells give less then a 1% long-term reconstitution when transplanted at a 1:1 ratio with wild-type bone marrow into irradiated mice
• mutant HSC bone marrow cells give only a 2% long-term reconstitution when transplanted at a 10:1 ratio
• poor reconstitution is observable as little as 4 weeks after transfer

immune system
• there is about a 3-fold reduction in pre-B cell CFUs isolated from bone marrow




Genotype
MGI:5305077
cn33
Allelic
Composition
Rr7tm3.1Kio/Rr7+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Rr7tm3.1Kio mutation (0 available); any Rr7 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal expression of Cd8a and Cd8b




Genotype
MGI:5490534
cn34
Allelic
Composition
Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrf5tm1.1Bstc mutation (1 available); any Adgrf5 mutation (73 available)
Adgrf5tm1.2Bstc mutation (0 available); any Adgrf5 mutation (73 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
N
• mice exhibit normal surfactant homeostasis in the lung




Genotype
MGI:6295912
cn35
Allelic
Composition
Cdk5rap3tm1c(EUCOMM)Hmgu/Cdk5rap3tm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5rap3tm1c(EUCOMM)Hmgu mutation (0 available); any Cdk5rap3 mutation (20 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice survive to adulthood

hematopoietic system




Genotype
MGI:6712732
cn36
Allelic
Composition
Il22tm1.1Lex/Il22tm1.1Lex
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Il22tm1.1Lex mutation (2 available); any Il22 mutation (27 available)
Riok2tm1c(KOMP)Wtsi mutation (0 available); any Riok2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice show an increase in RII and RIV erythroid precursors compared to IL-22-sufficient Riok2-haploinsufficent mice on day 7 after treatments with phenylhydrazine
• mice exhibit increased numbers of peripheral blood red blood cells compared to IL-22-sufficient Riok2-haploinsufficent mice on day 7 after treatments with phenylhydrazine to induce acute hemolytic stress

homeostasis/metabolism
• mice show alleviation of the stress-induced (via phenylhydrazine treatment) anemia seen in IL-22-sufficient Riok2-haploinsufficent mice




Genotype
MGI:5640745
cn37
Allelic
Composition
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• decreased numbers of mature erythrocytes
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells
• elevated reticulocyte counts

homeostasis/metabolism
• high levels of serum erythropoietin
• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type

immune system
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells




Genotype
MGI:5640746
cn38
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (57 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased red blood cell counts
• high hematocrit
• mild thrombocytosis
• elevated reticulocyte counts

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycythemia vera DOID:8997 OMIM:263300
J:220728




Genotype
MGI:5640744
cn39
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (57 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• decreased numbers of mature erythrocytes
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells
• elevated reticulocyte counts

homeostasis/metabolism
• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type

immune system
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells




Genotype
MGI:6513971
cn40
Allelic
Composition
Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Rptortm1.1Dmsa/Rptor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S/SvEv * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Rfx7tm1.1Ggaur mutation (0 available); any Rfx7 mutation (78 available)
Rptortm1.1Dmsa mutation (1 available); any Rptor mutation (115 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduced cell size and granularity but not as much as in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice
• although not as decreased in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice

hematopoietic system
• reduced cell size and granularity but not as much as in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice
• although not as decreased in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice




Genotype
MGI:6515779
cn41
Allelic
Composition
Sppl3tm1Itl/Sppl3tm1Itl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S/SvEv * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Sppl3tm1Itl mutation (0 available); any Sppl3 mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are born at normal Mendelian ratios and appear healthy

immune system
N
• mice have normal numbers of T (CD3+CD4+, CD3+CD8+) and B cells (CD19+B220+) in spleen
• mice show reduced expression of several NK cell surface receptors and a severe defect in NK cell maturation, with a 3-fold loss of CD27+CD11b+ in spleen and a 2-fold loss of CD27+CD11b+ in the bone marrow, indicating a partial block in maturation at the CD27+CD11b- stage
• mice show a 2-fold increase in the total number of immature CD27+CD11b- NK cells in the spleen and bone marrow
• mice exhibit reduced numbers of peripheral NK cells; the number of NK cells (Lin-CD122+DX5+) is decreased ~2-fold in spleen and 3-fold in liver
• however, NK cell number is normal in the bone marrow
• mice show a 2.6-fold decrease in the most mature CD27-CD11b+ NK cells in bone marrow, and a 4.9-fold reduction of CD27-CD11b+ cells in spleen
• mice exhibit reduced clearance of MHC class I-deficient tumors in vivo; 48 h after i.p. injection, recovery of RMA/s tumor cells is 7% versus 1% in control mice
• in an in vitro YAC-1 target lysis assay, splenic NK cells (DX5+) show ~60% of the cytotoxic activity seen in control mice across a range of E:T ratios

hematopoietic system
N
• mice have normal numbers of T (CD3+CD4+, CD3+CD8+) and B cells (CD19+B220+) in spleen
• mice show reduced expression of several NK cell surface receptors and a severe defect in NK cell maturation, with a 3-fold loss of CD27+CD11b+ in spleen and a 2-fold loss of CD27+CD11b+ in the bone marrow, indicating a partial block in maturation at the CD27+CD11b- stage
• mice show a 2-fold increase in the total number of immature CD27+CD11b- NK cells in the spleen and bone marrow
• mice exhibit reduced numbers of peripheral NK cells; the number of NK cells (Lin-CD122+DX5+) is decreased ~2-fold in spleen and 3-fold in liver
• however, NK cell number is normal in the bone marrow
• mice show a 2.6-fold decrease in the most mature CD27-CD11b+ NK cells in bone marrow, and a 4.9-fold reduction of CD27-CD11b+ cells in spleen
• mice exhibit reduced clearance of MHC class I-deficient tumors in vivo; 48 h after i.p. injection, recovery of RMA/s tumor cells is 7% versus 1% in control mice
• in an in vitro YAC-1 target lysis assay, splenic NK cells (DX5+) show ~60% of the cytotoxic activity seen in control mice across a range of E:T ratios




Genotype
MGI:3810116
cn42
Allelic
Composition
Kmt5btm1Jnw/Kmt5btm1Jnw
Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Kmt5btm1Jnw mutation (0 available); any Kmt5b mutation (42 available)
Kmt5ctm1.1Jnw mutation (0 available); any Kmt5c mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• V(D)J recombination in B and T cells is normal
• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells
• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice
• however, there is no increase in Igh chromosomal aberrations
• the number of mature and re-circulating B cells is decreased compared to in wild-type mice
• however, the numbers of pro- and pre-B cells is normal

hematopoietic system
• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells
• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice
• however, there is no increase in Igh chromosomal aberrations
• the number of mature and re-circulating B cells is decreased compared to in wild-type mice
• however, the numbers of pro- and pre-B cells is normal




Genotype
MGI:5306351
cn43
Allelic
Composition
Kitltm2.1Sjm/Kitltm2.2Sjm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: BALB/cJ * C57BL * CBA/Ca * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (92 available)
Kitltm2.2Sjm mutation (0 available); any Kitl mutation (92 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity
• 2-fold as in Kitltm2.2Sjm heterozygotes in the bone marrow




Genotype
MGI:7451043
cn44
Allelic
Composition
Commd10Tg(Vav1-icre)A2Kio/0
Map3k7tm1.1Arte/Map3k7tm1.1Arte
Genetic
Background
involves: C57BL/10 * C57BL/6J * C57BL/6NTac * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Map3k7tm1.1Arte mutation (0 available); any Map3k7 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• more splenic neutrophils
• more B cells
• normal number of T cells
• more splenic B cells
• by BMDMs after 8h stimulation with Pam3CSK4, R848 or LPS
• by BMDMs after 8h stimulation with Pam3CSK4, R848 or LPS
• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS
• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS
• by BMDMs after 8h stimulation with Pam3CSK4 or R848
• by BMDMs after 4h stimulation with LPS
• normal by BMDMs after 8h stimulation with LPS
• by BMDMs after 8h stimulation with Pam3CSK4 or R848
• by peritoneal neutrophils after 7h and 16h stimulation with Pam3CSK4, R848 or LPS
• by BMDMs after 4h stimulation with LPS
• normal by BMDMs after 8h stimulation with LPS

hematopoietic system
• more splenic neutrophils
• more B cells
• normal number of T cells
• more splenic B cells

growth/size/body




Genotype
MGI:5314234
cn45
Allelic
Composition
Syktm1.1Nns/Syktm1.1Nns
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Syktm1.1Nns mutation (0 available); any Syk mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike null homozygotes, mice survive to adulthood

immune system
• at E14.5, mice exhibit blood-filled vessels unlike control mice
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

cardiovascular system
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

homeostasis/metabolism
• at E14.5




Genotype
MGI:5661695
cn46
Allelic
Composition
Cdh5tm8Dvst/Cdh5tm8Dvst
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh5tm8Dvst mutation (0 available); any Cdh5 mutation (53 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
N
• mice are viable and fertile and show no significant differences in fetal liver weight and cellularity at E13.5 relative to controls, indicating normal hematopoietic colonization of the fetal liver




Genotype
MGI:5776602
cn47
Allelic
Composition
Piezo1tm2.1Apat/Piezo1tm2.1Apat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Piezo1tm2.1Apat mutation (1 available); any Piezo1 mutation (87 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• spleens appear dark and redder than controls
• spleens contain an increased number of mature, but not immature, Ter119+, CD71- red blood cells
• Ca2+ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca2+ is increased
• red blood cells exhibit increased osmotic fragility

homeostasis/metabolism
• Ca2+ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca2+ is increased
• red blood cells are overhydrated, however, discoid morphology is normal
• decreased plasma haptoglobin concentration
• Ca2+ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca2+ is increased

immune system
• spleens appear dark and redder than controls
• spleens contain an increased number of mature, but not immature, Ter119+, CD71- red blood cells




Genotype
MGI:6513967
cn48
Allelic
Composition
Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Rfx7tm1.1Ggaur mutation (0 available); any Rfx7 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduced cell size and granularity but not as much as in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice
• although not as decreased in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice

hematopoietic system
• reduced cell size and granularity but not as much as in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice
• although not as decreased in Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur Commd10Tg(Vav1-icre)A2Kio/Commd10+ mice




Genotype
MGI:4942368
cn49
Allelic
Composition
Tg(Kit*D814V)3Roer/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Tg(Kit*D814V)3Roer mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• similar to the phenotype in mice carrying Tg(CMV-cre)1Cgn and Tg(Kit*D814V)3Roer




Genotype
MGI:4942367
cn50
Allelic
Composition
Tg(Kit*D814V)1Roer/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Tg(Kit*D814V)1Roer mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• similar to the phenotype in mice carrying Tg(CMV-cre)1Cgn and Tg(Kit*D814V)1Roer




Genotype
MGI:5564914
cn51
Allelic
Composition
Bcl11atm1Pwt/Bcl11atm1Pwt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation (0 available); any Bcl11a mutation (42 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• granulocytes, T cells, macrophage conventional dendritic cells and dendritic cell progenitors not affected in spleen and bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
• about a 2-fold decrease in the bone marrow

immune system
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
• following infection with human HSV strain 17

homeostasis/metabolism
• following infection with human HSV strain 17




Genotype
MGI:5553469
cn52
Allelic
Composition
Tg(JAK2*V617F)FF1Rsko/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Tg(JAK2*V617F)FF1Rsko mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
• bones are pale at 20 weeks of age, suggesting decreased erythropoiesis
• erythroid TER-119+ cells are reduced in the bone marrow but a compensatory increase is seen in the spleen at 20 weeks of age
• myeloid cells are the predominant cell population in the bone marrow and are increased in the spleen at 20 weeks of age
• liver shows extramedullary hematopoiesis at 20 weeks of age with highly atypical megakaryocytes, but islands with myelopoeisis and erythropoiesis are also seen
• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
• hematopoietic cells, including megakaryocytes are seen in the lung at 20 weeks of age
• bone marrow shows hypercellularity with trilineage hyperplasia at 20 weeks of age
• increase in numbers of megakaryocytes in the spleen and bone marrow at 20 weeks of age, most with morphological abnormalities such as hyperchromatic, hyperlobulated nuclei, and bizarre nuclear configuration, and often forming clusters
• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
• collagen-based culture indicates a small increase in CFU-MK in bone marrow and a massive expansion of CFU-MK in the spleen
• slight decrease in hemoglobin at 20 weeks of age but is normal at 10 weeks of age
• slight increase in neutrophils at 10 and 20 weeks of age
• thrombocytosis is seen at 10 weeks of age, with a massive increase in platelets at 20 weeks of age
• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
• destruction of normal splenic architecture by atypical hematopoiesis is seen in some sections of the spleen at 20 weeks of age
• seen at 20 weeks of age

immune system
• myeloid cells are the predominant cell population in the bone marrow and are increased in the spleen at 20 weeks of age
• slight increase in neutrophils at 10 and 20 weeks of age
• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
• destruction of normal splenic architecture by atypical hematopoiesis is seen in some sections of the spleen at 20 weeks of age
• seen at 20 weeks of age

skeleton
• dilated sinusoids with intrasinusoidal hematopoiesis are seen in the bone marrow at 20 weeks of age
• myeloid cells are the predominant cell population in the bone marrow
• presence of myelofibrosis at 20 weeks of age

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
essential thrombocythemia DOID:2224 OMIM:187950
OMIM:601977
OMIM:614521
J:134364




Genotype
MGI:6385521
cn53
Allelic
Composition
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Yeats4em1Zfa mutation (0 available); any Yeats4 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients cause impaired differentiation of ILC1-ILC3s
• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced indicting that innate lymphoid cell (ILC) lineage commitment from the alpha4Beta7+ CLP stage is affected
• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed
• however, cell rates of long-term HSCs, short-term HSCs, and multipotent progenitors are unaffected and frequencies of common lymphoid progenitors (CLPs) and alpha4Beta7+ CLPs, myeloid progenitors, including common myeloid progenitors, granulocyte-macrophage progenitors, and megakaryocyte-erythrocyte progenitors are normal
• decrease in group 1 innate lymphoid cells (ILC1s) in small intestinal intraepithelial lymphocytes and in the liver
• decrease in group 2 innate lymphoid cells (ILC2s) in the small intestine lamina propria and lungs
• decrease in group 3 innate lymphoid cells (ILC3s) is the small intestine lamina propria
• numbers of all innate lymphoid cell lineages are reduced
• numbers of ILC1s, ILC2s and ILC3s are decreased in small intestines of lethally irradiated CD45.1+ recipients transplanted with mutant CD45.2+ LSK cells
• IFN-gamma+ innate lymphoid cells are decreased in mesenteric lymph nodes of mice infected with Salmonella typhimurium
• total group 2 innate lymphoid cells (ILC2s) and IL-5 or IL-13 expressing ILC2s are reduced in the lungs upon intranasal administration of papain
• IL-22 producing group 3 innate lymphoid cells (ILC3s) are decreased in small intestines of Citrobacter rodentium infected mice

immune system
• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients cause impaired differentiation of ILC1-ILC3s
• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced indicting that innate lymphoid cell (ILC) lineage commitment from the alpha4Beta7+ CLP stage is affected
• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed
• however, cell rates of long-term HSCs, short-term HSCs, and multipotent progenitors are unaffected and frequencies of common lymphoid progenitors (CLPs) and alpha4Beta7+ CLPs, myeloid progenitors, including common myeloid progenitors, granulocyte-macrophage progenitors, and megakaryocyte-erythrocyte progenitors are normal
• decrease in group 1 innate lymphoid cells (ILC1s) in small intestinal intraepithelial lymphocytes and in the liver
• decrease in group 2 innate lymphoid cells (ILC2s) in the small intestine lamina propria and lungs
• decrease in group 3 innate lymphoid cells (ILC3s) is the small intestine lamina propria
• numbers of all innate lymphoid cell lineages are reduced
• numbers of ILC1s, ILC2s and ILC3s are decreased in small intestines of lethally irradiated CD45.1+ recipients transplanted with mutant CD45.2+ LSK cells
• IFN-gamma+ innate lymphoid cells are decreased in mesenteric lymph nodes of mice infected with Salmonella typhimurium
• total group 2 innate lymphoid cells (ILC2s) and IL-5 or IL-13 expressing ILC2s are reduced in the lungs upon intranasal administration of papain
• IL-22 producing group 3 innate lymphoid cells (ILC3s) are decreased in small intestines of Citrobacter rodentium infected mice
• numbers of intestinal lymphoid follicles are reduced
• numbers of Peyers patches are reduced
• group 1 innate lymphoid cells show impaired production of IFN-gamma in response to Salmonella typhimurium infection
• IL-22 secreted by ILC3s in lamina propria lymphocytes is reduced in Citrobacter rodentium infected mice
• concentration of IL-12 in bronchoalveolar lavage fluid is reduced when mice are administered papain
• concentration of IL-5 in bronchoalveolar lavage fluid is reduced when mice are administered papain
• leukocyte infiltration is reduced in lungs upon treatment with papain
• eosinophil infiltration in bronchoalveolar lavage fluid and lungs is reduced upon treatment with papain
• mice exhibit a higher number of Salmonella typhimurium CFUs in the mesenteric lymph nodes than controls
• mice exhibit increased susceptibility to Citrobacter rodentium infection, showing increased bacterial CFUs in feces and spleen, accelerated weight loss, shortened colon length and persistent intestinal damage




Genotype
MGI:5496262
cn54
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice do not show any abnormalities




Genotype
MGI:5438280
cn55
Allelic
Composition
Idh1tm2Mak/Idh1tm2Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Idh1tm2Mak mutation (0 available); any Idh1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hematopoietical parameters in peripheral blood and normal bone marrow cell numbers
• increase in common lymphocyte progenitor cells in the bone marrow and spleen
• increase in megakaryocyte-erythroid progenitors in the spleen
• increase in LSK and lineage-restricted progenitors in the bone marrow and spleen
• increase in LK in the spleen




Genotype
MGI:5496264
cn56
Allelic
Composition
Gt(ROSA)26Sortm2(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Gt(ROSA)26Sortm2(CAG-PSTPIP1*)Dtg mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal behavior

growth/size/body
N
• mice exhibit normal body weight

immune system
N
• mice produce normal levels of proinflammatory cytokines when provoked with inflammasome-activating stimuli




Genotype
MGI:6303639
cn57
Allelic
Composition
Atp6v0a2tm1Kdb/Atp6v0a2tm1Kdb
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6v0a2tm1Kdb mutation (0 available); any Atp6v0a2 mutation (52 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• population of lymphoid cells in spleen is severely diminished
• total T cells are reduced 4.8-fold and 16.6-fold in spleen and blood, respectively
• only the alpha-beta T cells, not the gamma-delta T cells, are diminished in the spleen and blood
• the alpha-beta T cell percentage is reduced 6.23-fold and cell number is reduced 21-fold in the spleen
• similar reductions in alpha-beta T cells is seen in the thymus and bone marrow
• percentage of CD4+ T helper cells is reduced 25.71-fold in the spleen and 58.3-fold in the blood
• percentage of CD8+ cytotoxic T cells is reduced 13.73-fold in the spleen and 11.16-fold in the blood

immune system
• population of lymphoid cells in spleen is severely diminished
• total T cells are reduced 4.8-fold and 16.6-fold in spleen and blood, respectively
• only the alpha-beta T cells, not the gamma-delta T cells, are diminished in the spleen and blood
• the alpha-beta T cell percentage is reduced 6.23-fold and cell number is reduced 21-fold in the spleen
• similar reductions in alpha-beta T cells is seen in the thymus and bone marrow
• percentage of CD4+ T helper cells is reduced 25.71-fold in the spleen and 58.3-fold in the blood
• percentage of CD8+ cytotoxic T cells is reduced 13.73-fold in the spleen and 11.16-fold in the blood

neoplasm
• 14 days after tumor cell implantation, breast tumor cells metastasize to the lungs of mutant mice but not control mice
• mice implanted with a syngeneic tumor cell line E0771 in the 4th mammary foot pad show a faster rate of tumor growth and grow larger than in control mice implanted with tumor cells
• twice as many myeloid derived suppressor cells are present in the tumor microenvironment compared to controls
• fewer lymphoid cells are recruited to the tumor microenvironment compared to controls, with reduced CD3+CD19- T cell population due to reduced numbers of CD3+CD19-gamma-deltaTCR- alpha-beta T cells
• the tumor microenvironment shows a reduction in both CD4+ T helper cells and CD8+ cytotoxic T cell populations compared to controls
• mice implanted with a syngeneic tumor cell line E0771 in the 4th mammary foot pad show a faster rate of tumor growth than in control mice implanted with tumor cells




Genotype
MGI:7281769
cn58
Allelic
Composition
Satb1tm2Kos/Satb1tm2Kos
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Satb1tm2Kos mutation (0 available); any Satb1 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice start to die around 24 weeks of age
• renal failure is cause of death

endocrine/exocrine glands
• autoimmune destruction of the salivary gland
• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks
• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age
• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present
• number of B cells gradually increase and dominate in older mice
• immune cell infiltration is seen in the pancreas, however impaired glucose tolerance is not seen

immune system
• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age
• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present
• number of B cells gradually increase and dominate in older mice
• immune cell infiltration is seen in the pancreas, however impaired glucose tolerance is not seen
• splenic Foxp3+CD25+ Treg cells are absent in mice from birth until 1 week of age, however no difference in the number of Treg cells is seen after 2 weeks of age
• mice develop Sjogren's syndrome by 4 weeks of age, with females being more susceptible and presenting earlier onset of the disease than males
• mice show T cell-dominant immune cell infiltration in the salivary glands at 4 weeks and a gradual increase in the frequency of B cells, and an increase in anti-SSA and anti-SSB antibodies around 8 weeks of age
• transfer or T cells from mutant cervical lymph nodes, but not spleen, is sufficient to induce the development of Sjogren's syndrome in RAG2 null mice
• 3-day-old mice transferred with Treg cells derived from mature wild-type spleen show improved xerostomia, although saliva production is still reduced, a lesser degree of lymphocyte infiltration into salivary glands is seen and mice are protected against development of Sjogren's syndrome
• mice develop lupus nephritis
• presence of anti-SSA and anti-SSB antibodies which are higher than in wild-type mice at 10 and 7 weeks of age, respectively
• ANA are detected at high levels after 15 weeks of age
• mice develop lupus nephritis after failure of salivary gland function

digestive/alimentary system
• autoimmune destruction of the salivary gland
• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks
• immune cell infiltration and destruction of the salivary gland is seen at 4 weeks of age and continues even after 8 weeks of age; magnitude of immune cell infiltration progressively increases with age
• CD4+ T cells are the major cell infiltrates at 4 weeks, however CD8+ T cells and CD4+CD8+ cells are present
• number of B cells gradually increase and dominate in older mice

hematopoietic system
• splenic Foxp3+CD25+ Treg cells are absent in mice from birth until 1 week of age, however no difference in the number of Treg cells is seen after 2 weeks of age

homeostasis/metabolism
• saliva production is decreased by 4 weeks of age in females and decreased in both males and females by 8 weeks of age; saliva production reaches the lowest level at around 8 weeks
• some mice exhibit proteinuria after 15 weeks of age

renal/urinary system
• some mice exhibit proteinuria after 15 weeks of age
• mice develop lupus nephritis after failure of salivary gland function
• IgM and IgG deposition, most likely a part of immune complexes, is seen around the glomerulus in the kidneys at 15 weeks of age
• a component of complement C3 is present in association with Ig deposition, suggestions that kidney lesions resembling lupus nephritis develop in aged mice
• no kidney lesions are seen at 4-5 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Sjogren's syndrome DOID:12894 OMIM:270150
J:252606




Genotype
MGI:7311733
cn59
Allelic
Composition
A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal development of innate lymphoid cell progenitors

hematopoietic system
• reduced absolute numbers of ILC3 cells
• however, ILC1 and ILC2s numbers are normal




Genotype
MGI:5488604
cn60
Allelic
Composition
Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Commd10Tg(Vav1-icre)A2Kio/?
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• normal cellularity and hematopoietic stem cell frequency
• bone marrow/spleen lineage composition is normal




Genotype
MGI:5301602
cn61
Allelic
Composition
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Rc3h1tm1.1Mass mutation (0 available); any Rc3h1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Increased spleen size in Rc3h1tm1.1Mass/Rc3h1tm1.1MassCommd10Tg(Vav1-icre)A2Kio/0 mice

immune system
N
• mice exhibit normal T cell development and autoimmunity
• 1.5-fold but not as severe as in Rc3h1san homozygotes
• 1.5-fold
• in the bone marrow
• immature and re-circulating B cells
• increased numbers in the spleen
• mice exhibit increased spontaneous germinal center formation compared with control mice

hematopoietic system
• 1.5-fold but not as severe as in Rc3h1san homozygotes
• 1.5-fold
• in the bone marrow
• immature and re-circulating B cells
• increased numbers in the spleen
• mice exhibit increased spontaneous germinal center formation compared with control mice

growth/size/body
• 1.5-fold but not as severe as in Rc3h1san homozygotes
• 1.5-fold




Genotype
MGI:6267348
cn62
Allelic
Composition
Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (36 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no viable mice are produced




Genotype
MGI:6696062
cn63
Allelic
Composition
Zbtb38em1Dbhat/Zbtb38em1Dbhat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Zbtb38em1Dbhat mutation (1 available); any Zbtb38 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal normal hematopoietic cell development, primary antibody responses to hapten-protein antigens, and secondary B cell responses




Genotype
MGI:6267349
cn64
Allelic
Composition
Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1btm2c(EUCOMM)Hmgu mutation (0 available); any Chaf1b mutation (36 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• bone marrow cells from pIpC-treated mice fail to form fewer colonies in culture compared with control cell
• modest reduction in pIpC-treated mice
• in the bone marrow cells from pIpC-treated mice with an increase in the percentage of LK cells, decrease in LSK cells and increased proportion of short-term SLAM+ cells




Genotype
MGI:5902764
cn65
Allelic
Composition
Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca
Cell Lines EPD0069_1_G06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brpf1tm1c(EUCOMM)Wtsi mutation (0 available); any Brpf1 mutation (37 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced histone H3K23 acetylation in thymus and spleen extracts




Genotype
MGI:5604905
cn66
Allelic
Composition
Jagn1tm1c(EUCOMM)Hmgu/Jagn1tm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Jagn1tm1c(EUCOMM)Hmgu mutation (0 available); any Jagn1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• neutrophils show reduced numbers of primary and secondary granules
• neutrophils show alterations in the glycosylation of proteins involved in cell adhesion and cytotoxicity
• however, mice exhibit normal numbers of neutrophils in the bone marrow, secondary lymphoid organs and blood
• neutrophils, but not macrophages and dendritic cells, exhibit impaired killing of Candida albicans
• neutrophils show decreased ability to release myeloperoxidase when challenged in vitro with Candida albicans
• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)
• recruitment of neutrophils to the peritoneal cavity following Candida albicans injection into the peritoneal cavity is reduced and mice show decreased recruitment of neutrophils to the kidney and lung 24 hours following systemic infection with Candida albicans, indicating that neutrophils cannot effectively migrate to the site of infection
• mice are unable to mount an efficient neutrophil-dependent immune response to the human fungal pathogen Candida albicans, showing increased weight loss, massively increased fungal burdens, severe multifocal tubulointerstitial nephritis, splenitis with expanded white pulp, diffuse inflammatory infiltrations into the liver and lungs, and decreased TNF-alpha levels in the serum and intraperitonal lavage and succumb earlier to Candida albicans infection
• treatment with granulocyte/macrophage colony-stimulating factor (GM-CSF) protects mutants from weight loss, rescues the neutrophil recruitment defects and increases survival after Candida albicans challenge

cellular
• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)

hematopoietic system
• neutrophils show reduced numbers of primary and secondary granules
• neutrophils show alterations in the glycosylation of proteins involved in cell adhesion and cytotoxicity
• however, mice exhibit normal numbers of neutrophils in the bone marrow, secondary lymphoid organs and blood
• neutrophils, but not macrophages and dendritic cells, exhibit impaired killing of Candida albicans
• neutrophils show decreased ability to release myeloperoxidase when challenged in vitro with Candida albicans
• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)
• recruitment of neutrophils to the peritoneal cavity following Candida albicans injection into the peritoneal cavity is reduced and mice show decreased recruitment of neutrophils to the kidney and lung 24 hours following systemic infection with Candida albicans, indicating that neutrophils cannot effectively migrate to the site of infection




Genotype
MGI:6712637
cn67
Allelic
Composition
Riok2tm1c(KOMP)Wtsi/Riok2tm1c(KOMP)Wtsi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Riok2tm1c(KOMP)Wtsi mutation (0 available); any Riok2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous mice are recovered




Genotype
MGI:6712737
cn68
Allelic
Composition
Il22ra1tm1.1Koll/Il22ra1tm1.1Koll
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Il22ra1tm1.1Koll mutation (1 available); any Il22ra1 mutation (30 available)
Riok2tm1c(KOMP)Wtsi mutation (0 available); any Riok2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice show an improvement in peripheral blood red blood cell numbers and hematocrit levels, and an increase in RIII and RIV erythroid precursors in the bone marrow compared to Il22ra1-sufficient Riok2-haploinsufficent mice




Genotype
MGI:6712638
cn69
Allelic
Composition
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Riok2tm1c(KOMP)Wtsi mutation (0 available); any Riok2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 8-12 week of mice exposed to acute hemolytic stress induced by phenylhydrazine treatment succumb faster to a lethal dose of phenylhydrazine than controls

hematopoietic system
• mice exhibit impaired erythropoiesis in the bone marrow
• mice over 60 weeks of age exhibit anemia
• 8-12 week of mice exposed to acute hemolytic stress (induced by nonlethal phenylhydrazine treatment) develop more severe anemia and have a delayed red blood cell recovery response compared to controls and succumb faster to a lethal dose of phenylhydrazine
• wild-type mice transplanted with mutant whole bone marrow develop anemia
• treatment of mice with a neutralizing IL-22 antibody reverses phenylhydrazine-induced anemia
• the percentage of proliferating granulocyte-macrophage progenitors in the bone marrow is increased
• anemia in young phenylhydrazine-administered mice seen on day 7 is preceded by a reduction in bone marrow RIII and RIV erythroid precursor frequency on day 6, indicating an erythroid differentiation defect
• aged mice exhibit reduced peripheral blood red blood cell numbers
• in aged mice
• mice exhibit a decreased percentage of neutrophils (neutropenia)
• aged mice show increased numbers of natural killer T cells
• mice exhibit an increased percentage of monocytes (monocytosis)
• LSK (lineage-Sca-1+Kit+) cells from the bone marrow supplemented with growth factors give rise to an increased percentage of CD11b+ myeloid cells, indicating a cell-intrinsic myeloproliferative effect
• frequency and numbers of early hematopoietic progenitors are normal in young mice, however long-term hematopoietic stem cells (LT-HSCs) are increased in the bone marrow of aged mice
• aged mice show increased numbers of splenic IL-22+CD4+T cells
• mice exhibit an increase in apoptosis of erythroid precursors
• erythroid precursors show a decrease in cell quiescence with cell cycle block at the G1 phase
• treatment of mice with a neutralizing IL-22 antibody reduces the frequency of apoptotic erythroid precursors
• TH22 cells secrete elevated concentrations of IL-22
• bone marrow cells show reduced nascent protein synthesis in vivo

homeostasis/metabolism
• the concentration of IL-22 in the serum and bone marrow fluid of aged mice is higher than in controls
• 8-12 week of mice exposed to acute hemolytic stress induced by phenylhydrazine treatment succumb faster to a lethal dose of phenylhydrazine than controls
• 8-12 week of mice exposed to acute hemolytic stress induced by nonlethal phenylhydrazine treatment develop more severe anemia and have a delayed red blood cell recovery response compared to controls
• treatment of mice with a neutralizing IL-22 antibody reverses phenylhydrazine-induced anemia

immune system
• TH22 cells secrete elevated concentrations of IL-22
• the concentration of IL-22 in the serum and bone marrow fluid of aged mice is higher than in controls
• aged mice show increased numbers of innate lymphoid cells
• mice exhibit a decreased percentage of neutrophils (neutropenia)
• aged mice show increased numbers of natural killer T cells
• mice exhibit an increased percentage of monocytes (monocytosis)
• aged mice show increased numbers of splenic IL-22+CD4+T cells
• naive T cells polarized toward the TH22 cell lineage show an increase in IL-22 secretion




Genotype
MGI:5908557
cn70
Allelic
Composition
Commd10Tg(Vav1-icre)A2Kio/?
Tnfrsf14tm1.1Kro/Tnfrsf14tm1.1Kro
Genetic
Background
involves: C57BL/6NCrl * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Tnfrsf14tm1.1Kro mutation (1 available); any Tnfrsf14 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following corneal inoculation of HSV1, corneas have lower viral titers as compared to controls
• myeloid cell infiltration into the cornea 14 days post HSV1 infection is reduced as compared to controls

behavior/neurological
• following corneal inoculation of HSV1, corneal reflexes (as measured by corneal touch threshold) are largely retained in contrast to infected controls




Genotype
MGI:6367554
cn71
Allelic
Composition
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Ociad1tm1Msin/Ociad1tm1Msin
Genetic
Background
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Ociad1tm1Msin mutation (0 available); any Ociad1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in peripheral blood cell numbers
• increase in hematopoietic stem cell frequencies




Genotype
MGI:5527435
cn72
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are observed at P10

hematopoietic system
• disturbed hematopoietic development in adult hematopoietic progenitor cells
• severe in some mice
• reduced total number of colony forming units from bone marrow cells




Genotype
MGI:5295638
cn73
Allelic
Composition
Atg7tm1Tchi/Atg7tm1Tchi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (3 available); any Atg7 mutation (50 available)
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduction in most myeloid progenitors
• numbers of myeloid subsets CD11b+Gr1- and CD11b-Gr1+ are reduced in blood and decrease further over time
• overall bone marrow cell count is reduced
• common lymphoid progenitors (Lin-Flt3HighIL7RaHighSca-1Lowc-KitLow) are reduced in mutants
• numbers of CCR9+ lymphoid-primed multipotent progenitors are reduced in the bone marrow of mutants
• mutant LSK (Lin-Sca-1+c-Kit+) cells accumulate mitochondria, mitochondrial superoxide, and DNA damage and exhibit increased levels of apoptosis and proliferation
• numbers of hematopoietic stem cells are reduced in all mutants, regardless of disease progression
• absolute numbers of LSK (Lin-Sca-1+c-Kit+) cells significantly increased in asymptomatic 7 week old mutants, however as they develop symptoms, the frequency of LSK cells falls to wild-type levels
• the Lin-Sca-1-c-Kit+ (LK) compartment, containing more mature hematopoietic progenitors, is decreased
• numbers of CD11b+Gr1+ cells are increased in the blood at 5 and 6 weeks of age but then decrease to below wild-type levels at 8 weeks of age
• CD11b+Gr1+ cells in the spleen and bone marrow are increased and show higher proliferation rates
• mutants exhibit presence of atypical myeloid infiltrates in a wide range of organs
• mutants are cytopenic for all blood leukocyte populations except for CD11b+Gr1+ cells
• absolute cell counts of B cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• immature NK cells (Lin-CD3-CD122+NK1.1+DX5+) are depleted in the bone marrow
• absolute cell counts of NK cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• absolute cell counts of T cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• adult bone marrow cells from mutants transplanted together with CD45.1+ wild-type bone marrow cells into lethally irradiated wild-type hosts fail to contribute to reconstitution of cells in the hosts while in noncompetitive reconstitution experiments, lethally irradiated mice die within 4 weeks after transplantation with mutant bone marrow cells, indicating loss of hematopoietic stem cell activity

immune system
• numbers of CD11b+Gr1+ cells are increased in the blood at 5 and 6 weeks of age but then decrease to below wild-type levels at 8 weeks of age
• CD11b+Gr1+ cells in the spleen and bone marrow are increased and show higher proliferation rates
• mutants exhibit presence of atypical myeloid infiltrates in a wide range of organs
• mutants are cytopenic for all blood leukocyte populations except for CD11b+Gr1+ cells
• absolute cell counts of B cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• immature NK cells (Lin-CD3-CD122+NK1.1+DX5+) are depleted in the bone marrow
• absolute cell counts of NK cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• absolute cell counts of T cells are decreased in the peripheral blood of mutants and numbers drop steadily over time

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myelodysplastic syndrome DOID:0050908 OMIM:614286
J:176843




Genotype
MGI:6712735
cx74
Allelic
Composition
Trp53tm1Tyj/Trp53tm1Tyj
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• naive T cells polarized toward the TH22 cell lineage show a decrease in IL-22 secretion




Genotype
MGI:6712736
cx75
Allelic
Composition
Il22tm1.1Lex/Il22tm1.1Lex
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (2 available); any Commd10 mutation (23 available)
Il22tm1.1Lex mutation (2 available); any Il22 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice show an increase in peripheral red blood cells after treatment with phenylhydrazine to induce acute hemolytic stress

homeostasis/metabolism
• mice show an increase in peripheral red blood cells after treatment with phenylhydrazine to induce acute hemolytic stress





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory