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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Vav1-icre)A2Kio
transgene insertion A2, Dimitris Kioussis
MGI:2449949
Summary 45 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Adh5tm1.1Llli/Adh5tm1.1Llli
Tg(Vav1-icre)A2Kio/0
B6.Cg-Adh5tm1.1Llli Tg(Vav1-icre)A2Kio MGI:5049928
cn2
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Tg(Vav1-icre)A2Kio/0
B6.Cg-Egln1tm2.1Fsl Tg(Vav1-icre)A2Kio MGI:5525143
cn3
Patz1tm1.2Welm/Patz1tm1.2Welm
Tg(Vav1-icre)A2Kio/0
B6.Cg-Patz1tm1.2Welm Tg(Vav1-icre)A2Kio MGI:5572830
cn4
Pkn3tm1.1Mrl/Pkn3tm1.1Mrl
Tg(Vav1-icre)A2Kio/0
B6.Cg-Pkn3tm1.1Mrl Tg(Vav1-icre)A2Kio MGI:5688866
cn5
Snai1tm1.1Stjw/Snai1tm1.1Stjw
Tg(Vav1-icre)A2Kio/0
B6.Cg-Snai1tm1.1Stjw Tg(Vav1-icre)A2Kio MGI:5659610
cn6
Cdkn1atm1Led/Cdkn1atm1Led
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Tg(Vav1-icre)A2Kio/0
B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Tg(Vav1-icre)A2Kio MGI:5006710
cn7
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Tg(Vav1-icre)A2Kio/0
B6.Cg-Zbtb17tm1Cksn Tg(Vav1-icre)A2Kio MGI:5006709
cn8
Tg(Vav1-icre)A2Kio/0
Zfp318tm1.1Jhws/Zfp318tm1.1Jhws
B6.Cg-Zfp318tm1.1Jhws TgVav1-creA2Kio MGI:5606282
cn9
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Tg(Vav1-icre)A2Kio/0
B6NTac.Cg-Ifngr1tm1.1Rds Tg(Vav1-icre)A2Kio MGI:5558063
cn10
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Tg(Vav1-icre)A2Kio/0
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:5525153
cn11
Cd40lgtm1Parl/Cd40lgtm1Parl
Tg(Vav1-icre)A2Kio/0
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:5585442
cn12
Cd40lgtm1Parl/Y
Tg(Vav1-icre)A2Kio/0
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca MGI:5585443
cn13
F8tm1.1Rmnt/F8tm1.1Rmnt
Tg(Vav1-icre)A2Kio/0
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL MGI:5582833
cn14
Dhx36tm1.2Pmt/Dhx36tm1.2Pmt
Tg(Vav1-icre)A2Kio/0
involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca MGI:5427982
cn15
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Vav1-icre)A2Kio/0
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:3804186
cn16
Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Vav1-icre)A2Kio/0
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:3804204
cn17
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Vav1-icre)A2Kio/0
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca MGI:4821304
cn18
Idh1tm1Mak/Idh1tm1Mak
Tg(Vav1-icre)A2Kio/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca MGI:5438277
cn19
Myd88tm1Defr/Myd88tm1Defr
Tg(Vav1-icre)A2Kio/0
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3809645
cn20
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Ikzf1-Tcfe2a,GFP)1Mbu/0
Tg(Vav1-icre)A2Kio/0
involves: 129P2/OlaHsd * C57BL * CBA MGI:3804203
cn21
Syktm1.1Nns/Syktm1.1Nns
Tg(Tie1-cre)9Ref/0
Tg(Vav1-icre)A2Kio/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca MGI:5314235
cn22
Bmi1tm1Sgon/Bmi1tm1Sgon
Tg(Vav1-icre)A2Kio/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca MGI:5693398
cn23
Rr7tm3.1Kio/Rr7+
Tg(Vav1-icre)A2Kio/0
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca MGI:5305077
cn24
Kmt2atm1Brad/Kmt2atm1Brad
Tg(Vav1-icre)A2Kio/?
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca MGI:3849329
cn25
Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(Vav1-icre)A2Kio/0
involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca MGI:5490534
cn26
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Tg(Vav1-icre)A2Kio/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640746
cn27
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Vav1-icre)A2Kio/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640744
cn28
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Vav1-icre)A2Kio/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL MGI:5640745
cn29
Suv420h1tm1Jnw/Suv420h1tm1Jnw
Suv420h2tm1.1Jnw/Suv420h2tm1.1Jnw
Tg(Vav1-icre)A2Kio/0
involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca MGI:3810116
cn30
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Vav1-icre)A2Kio/0
involves: BALB/cJ * C57BL * CBA/Ca * SJL MGI:5306351
cn31
Cdh5tm8Dvst/Cdh5tm8Dvst
Tg(Vav1-icre)A2Kio/0
involves: C57BL/10 * CBA/Ca MGI:5661695
cn32
Syktm1.1Nns/Syktm1.1Nns
Tg(Vav1-icre)A2Kio/0
involves: C57BL/10 * CBA/Ca MGI:5314234
cn33
Piezo1tm2.1Apat/Piezo1tm2.1Apat
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA MGI:5776602
cn34
Tg(JAK2*V617F)FF1Rsko/0
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5553469
cn35
Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg/Gt(ROSA)26Sor+
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5496262
cn36
Bcl11atm1Pwt/Bcl11atm1Pwt
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5564914
cn37
Idh1tm2Mak/Idh1tm2Mak
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5438280
cn38
Tg(Kit*D814V)3Roer/0
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:4942368
cn39
Tg(Kit*D814V)1Roer/0
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:4942367
cn40
Gt(ROSA)26Sortm2(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:5496264
cn41
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL MGI:5301602
cn42
Jagn1tm1c(EUCOMM)Hmgu/Jagn1tm1c(EUCOMM)Hmgu
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6N * C57BL/10 * CBA/Ca MGI:5604905
cn43
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj MGI:5527435
cn44
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Vav1-icre)A2Kio/0
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj MGI:5295638
cn45
Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Vav1-icre)A2Kio/?
involves: CBA/Ca * C57BL/6 * C57BL/10 MGI:5488604


Genotype
MGI:5049928
cn1
Allelic
Composition
Adh5tm1.1Llli/Adh5tm1.1Llli
Tg(Vav1-icre)A2Kio/0
Genetic
Background
B6.Cg-Adh5tm1.1Llli Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh5tm1.1Llli mutation (0 available); any Adh5 mutation (12 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival following diethylnitrosamine (DEN) challenged




Genotype
MGI:5525143
cn2
Allelic
Composition
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Tg(Vav1-icre)A2Kio/0
Genetic
Background
B6.Cg-Egln1tm2.1Fsl Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2.1Fsl mutation (0 available); any Egln1 mutation (11 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased numbers of BFU-E colonies are observed at both high and low concentrations of erythropoietin
• mice exhibit erythrocytosis, however, erythropoietin levels are not increased
• hematocrits are modestly increased over controls




Genotype
MGI:5572830
cn3
Allelic
Composition
Patz1tm1.2Welm/Patz1tm1.2Welm
Tg(Vav1-icre)A2Kio/0
Genetic
Background
B6.Cg-Patz1tm1.2Welm Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1tm1.2Welm mutation (0 available); any Patz1 mutation (40 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice subjected to systemic anaphylaxis exhibit normal histamine release response of mast cells in vivo
• mice exhibit normal cutaneous anaphylaxis response
• bone marrow-derived mast cells exhibit normal early and late effector functions upon Fcer1-mediated activation
• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal
• in bone marrow-derived mast cells activated with TNP

cellular
• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal

hematopoietic system
• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal




Genotype
MGI:5688866
cn4
Allelic
Composition
Pkn3tm1.1Mrl/Pkn3tm1.1Mrl
Tg(Vav1-icre)A2Kio/0
Genetic
Background
B6.Cg-Pkn3tm1.1Mrl Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkn3tm1.1Mrl mutation (0 available); any Pkn3 mutation (21 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• hematopoietic stem cell numbers are similar to controls at 6-8 weeks of age and cells perform similar to control cells in a competitive transplantation assay




Genotype
MGI:5659610
cn5
Allelic
Composition
Snai1tm1.1Stjw/Snai1tm1.1Stjw
Tg(Vav1-icre)A2Kio/0
Genetic
Background
B6.Cg-Snai1tm1.1Stjw Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1tm1.1Stjw mutation (0 available); any Snai1 mutation (3 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable with no gross abnormalities at E14.5, E17.5 and P1
• hematopoietic progenitors from E9.5 embryos demonstrate comparable erythroid colony formation




Genotype
MGI:5006710
cn6
Allelic
Composition
Cdkn1atm1Led/Cdkn1atm1Led
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Tg(Vav1-icre)A2Kio/0
Genetic
Background
B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (46 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• double negative to double positive differentiation is blocked unlike in wild-type mice

hematopoietic system
• double negative to double positive differentiation is blocked unlike in wild-type mice




Genotype
MGI:5006709
cn7
Allelic
Composition
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Tg(Vav1-icre)A2Kio/0
Genetic
Background
B6.Cg-Zbtb17tm1Cksn Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vav1-icre)A2Kio mutation (2 available)
Zbtb17tm1Cksn mutation (1 available); any Zbtb17 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• pro-T cells exhibit excessive cell death unlike wild-type cells
• 100-fold reduction in cellularity
• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice
• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro
• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells

hematopoietic system
• pro-T cells exhibit excessive cell death unlike wild-type cells
• 100-fold reduction in cellularity
• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice
• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro
• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells

cellular
• pro-T cells exhibit excessive cell death unlike wild-type cells

endocrine/exocrine glands
• 100-fold reduction in cellularity
• early T-cell precursors in the thymus are reduced compared to in wild-type mice
• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice
• DN1a/b cells are decreased 230-fold compared to in wild-type mice
• 100-fold reduction in DN2a cells
• 40-fold reduction in DN2b cells
• 3-fold reduction in DN3a cells
• 10-fold reduction in DN3b cells




Genotype
MGI:5606282
cn8
Allelic
Composition
Tg(Vav1-icre)A2Kio/0
Zfp318tm1.1Jhws/Zfp318tm1.1Jhws
Genetic
Background
B6.Cg-Zfp318tm1.1Jhws TgVav1-creA2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vav1-icre)A2Kio mutation (2 available)
Zfp318tm1.1Jhws mutation (1 available); any Zfp318 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• slight decrease in splenic T2 B cells in 4 week old mice
• decreased levels of IgD in transitional type 1 and 2 (T1,2), follicular (FO) and marginal zone (MZ) B cell populations
• increased levels of IgM in transitional type 2 (T2), follicular (FO) and marginal zone (MZ) B cell populations

hematopoietic system
• slight decrease in splenic T2 B cells in 4 week old mice
• decreased levels of IgD in transitional type 1 and 2 (T1,2), follicular (FO) and marginal zone (MZ) B cell populations
• increased levels of IgM in transitional type 2 (T2), follicular (FO) and marginal zone (MZ) B cell populations




Genotype
MGI:5558063
cn9
Allelic
Composition
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Tg(Vav1-icre)A2Kio/0
Genetic
Background
B6NTac.Cg-Ifngr1tm1.1Rds Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1tm1.1Rds mutation (1 available); any Ifngr1 mutation (19 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

immune system
• mice infected with L. monocytogenes exhibit increased mortality and spleen and liver bacterial counts compared with control mice




Genotype
MGI:5525153
cn10
Allelic
Composition
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm1atm1.1Sho mutation (1 available); any Kdm1a mutation (27 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• hematopoietic stem and progenitor cell populations are distorted
• 30 fold decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+)
• found in femur and tibia of 5 day old mice as compared to control
• found in peripheral blood of 5 day old mice as compared to control
• found in peripheral blood of 5 day old mice as compared to control
• found in peripheral blood of 5 day old mice as compared to control
• 30 fold decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+)

immune system
• found in peripheral blood of 5 day old mice as compared to control

growth/size/body
• newborn pups are smaller than controls

mortality/aging
• lethality is a result severe anemia
• most mice die by day 10




Genotype
MGI:5585442
cn11
Allelic
Composition
Cd40lgtm1Parl/Cd40lgtm1Parl
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Parl mutation (0 available); any Cd40lg mutation (5 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hemograms
• decreased circulating platelets 2 min after administration of agonists

homeostasis/metabolism
N
• mice exhibit normal prothrombin tine and activated partial thromboplastin time

immune system




Genotype
MGI:5585443
cn12
Allelic
Composition
Cd40lgtm1Parl/Y
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Parl mutation (0 available); any Cd40lg mutation (5 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hemograms
• decreased circulating platelets 2 min after administration of agonists

homeostasis/metabolism
N
• mice exhibit normal prothrombin tine and activated partial thromboplastin time

immune system




Genotype
MGI:5582833
cn13
Allelic
Composition
F8tm1.1Rmnt/F8tm1.1Rmnt
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm1.1Rmnt mutation (1 available); any F8 mutation (13 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:5427982
cn14
Allelic
Composition
Dhx36tm1.2Pmt/Dhx36tm1.2Pmt
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx36tm1.2Pmt mutation (1 available); any Dhx36 mutation (25 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• without affecting architecture
• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.B and Ery.C in the bone marrow compared with control mice
• mice exhibit an increase in ProE and Ery.A fractions but a decrease in Ery.C in the spleen compared with control mice
• early erythropoiesis is partially blocked in association with a cell cycle defect
• proerythroblast exhibit reduced proliferation compared with control cells
• however, proerythroblast apoptosis rates are normal
• intrinsic as determined by bone marrow transplantation
• decrease in the granulocyte macrophage progenitor (GMP) cells in the bone marrow
• ProE cells are increased 3.6- and 74-fold in the bone marrow and spleen compared with control mice
• in the bone marrow
• 4.7-fold in the spleen
• secondary
• early long and short term hematopoietic stem cells are increased compared to in control mice
• however, the number of lymphoid-primed multipotent progenitors is normal and the increased in hematopoietic stem cells disappears in the alter stages of differentiation
• increase in the megakaryocyte-erythroid progenitor (MEP) cells in the spleen
• in adult mice
• reduced half-life

liver/biliary system
• in adult mice

renal/urinary system

cellular
• proerythroblast exhibit reduced proliferation compared with control cells

integument
• at birth

immune system
• without affecting architecture
• in adult mice

endocrine/exocrine glands
• without affecting architecture




Genotype
MGI:3804186
cn15
Allelic
Composition
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (25 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice lack committed c-Kit+CD19+ pro-B cells

immune system
• mice lack committed c-Kit+CD19+ pro-B cells




Genotype
MGI:3804204
cn16
Allelic
Composition
Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1tm1.1(Pax5)Mbu mutation (0 available); any Ikzf1 mutation (11 available)
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (25 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• development of pro-B cells is rescued
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent

hematopoietic system
• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent




Genotype
MGI:4821304
cn17
Allelic
Composition
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpjtm1Hon mutation (2 available); any Rbpj mutation (187 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• transplanted bone marrow progenitors transfected with BCR-ABL and NUP98-HOXA9 proliferate slower than similarly treated wild-type cells improving host survival




Genotype
MGI:5438277
cn18
Allelic
Composition
Idh1tm1Mak/Idh1tm1Mak
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idh1tm1Mak mutation (0 available); any Idh1 mutation (11 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hematopoietical parameters in peripheral blood and normal bone marrow cell numbers
• increase in common lymphocyte progenitor cells in the bone marrow and spleen
• increase in megakaryocyte-erythroid progenitors in the spleen
• increase in LSK and lineage-restricted progenitors in the bone marrow and spleen
• increase in LK in the spleen




Genotype
MGI:3809645
cn19
Allelic
Composition
Myd88tm1Defr/Myd88tm1Defr
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Defr mutation (3 available); any Myd88 mutation (24 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists
• NK cells in vivo have a blunted IFN-gamma response to LPS injections

hematopoietic system
• NK cells fail to make IFN-gamma in response to injections of TLR9 agonists
• NK cells in vivo have a blunted IFN-gamma response to LPS injections




Genotype
MGI:3804203
cn20
Allelic
Composition
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Ikzf1-Tcfe2a,GFP)1Mbu/0
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Mbu mutation (1 available); any Tcf3 mutation (25 available)
Tg(Ikzf1-Tcfe2a,GFP)1Mbu mutation (0 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• c-Kit+B220+ pro-B cells and c-Kit-B220+ developmental stages are rescued




Genotype
MGI:5314235
cn21
Allelic
Composition
Syktm1.1Nns/Syktm1.1Nns
Tg(Tie1-cre)9Ref/0
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.1Nns mutation (0 available); any Syk mutation (15 available)
Tg(Tie1-cre)9Ref mutation (1 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike null homozygotes, mice survive to adulthood

immune system
• at E14.5, mice exhibit blood-filled vessels unlike wild-type mice




Genotype
MGI:5693398
cn22
Allelic
Composition
Bmi1tm1Sgon/Bmi1tm1Sgon
Tg(Vav1-icre)A2Kio/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmi1tm1Sgon mutation (0 available); any Bmi1 mutation (15 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• born at the expected frequency and fertile
• 93% die by 24-26 weeks

hematopoietic system
• 4X smaller than controls in older mice
• with loss of cortico-medullary differentiation
• absolute numbers of progenitors reduced 2 fold
• reduced myeloid colony formation
• reduced erythroid colony formation
• cellularity reduced
• hypoplasia in femora
• significant and progressive increase of immunophenotypic common lymphoid fraction
• lymphoid colony frequency is reduced 4X
• increased proportion of cells in S/G2/M phase
• homing of cells to host bone marrow is reduced
• significant loss of B lymphocytes in young mice
• significant loss of T lymphocytes in young mice
• slight decrease in myeloid cells
• in bone marrow
• remaining cells unable to repopulate irradiated hosts
• stem cells fail to maintain quiescence
• 4X smaller than controls in older mice

immune system
• significant loss of B lymphocytes in young mice
• significant loss of T lymphocytes in young mice
• 4X smaller than controls in older mice
• with loss of cortico-medullary differentiation
• 4X smaller than controls in older mice

endocrine/exocrine glands
• 4X smaller than controls in older mice
• with loss of cortico-medullary differentiation




Genotype
MGI:5305077
cn23
Allelic
Composition
Rr7tm3.1Kio/Rr7+
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr7tm3.1Kio mutation (0 available); any Rr7 mutation (0 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal expression of Cd8a and Cd8b




Genotype
MGI:3849329
cn24
Allelic
Composition
Kmt2atm1Brad/Kmt2atm1Brad
Tg(Vav1-icre)A2Kio/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2atm1Brad mutation (0 available); any Kmt2a mutation (55 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• there is about a 2-fold reduction in myeloid CFU number isolated from E13.5 fetal livers
• a similar reduction in CFU is observed with bone marrow cells
• there is about a 3-fold reduction in pre-B cell CFUs isolated from bone marrow
• mutant HSC bone marrow cells give less then a 1% long-term reconstitution when transplanted at a 1:1 ratio with wild-type bone marrow into irradiated mice
• mutant HSC bone marrow cells give only a 2% long-term reconstitution when transplanted at a 10:1 ratio
• poor reconstitution is observable as little as 4 weeks after transfer

immune system
• there is about a 3-fold reduction in pre-B cell CFUs isolated from bone marrow




Genotype
MGI:5490534
cn25
Allelic
Composition
Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrf5tm1.1Bstc mutation (1 available); any Adgrf5 mutation (30 available)
Adgrf5tm1.2Bstc mutation (0 available); any Adgrf5 mutation (30 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
N
• mice exhibit normal surfactant homeostasis in the lung




Genotype
MGI:5640746
cn26
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (18 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (27 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increased red blood cell counts
• high hematocrit
• mild thrombocytosis
• elevated reticulocyte counts

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycythemia Vera; PV 263300 J:220728




Genotype
MGI:5640744
cn27
Allelic
Composition
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2tm1.2Ble mutation (0 available); any Jak2 mutation (18 available)
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (27 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• decreased numbers of mature erythrocytes
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells
• elevated reticulocyte counts

homeostasis/metabolism
• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type

immune system
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells




Genotype
MGI:5640745
cn28
Allelic
Composition
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Picalmtm1.1Tmae mutation (1 available); any Picalm mutation (27 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• decreased numbers of mature erythrocytes
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells
• elevated reticulocyte counts

homeostasis/metabolism
• high levels of serum erythropoietin
• transferrin/transferrin receptor endocytic rate is decreased as compared to wild-type

immune system
• decreased numbers of CD4+ T cells
• decreased numbers of CD8+ T cells




Genotype
MGI:3810116
cn29
Allelic
Composition
Suv420h1tm1Jnw/Suv420h1tm1Jnw
Suv420h2tm1.1Jnw/Suv420h2tm1.1Jnw
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suv420h1tm1Jnw mutation (0 available); any Suv420h1 mutation (21 available)
Suv420h2tm1.1Jnw mutation (0 available); any Suv420h2 mutation (15 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• V(D)J recombination in B and T cells is normal
• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells
• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice
• however, there is no increase in Igh chromosomal aberrations
• the number of mature and re-circulating B cells is decreased compared to in wild-type mice
• however, the numbers of pro- and pre-B cells is normal

hematopoietic system
• in a competitive reconstitution assay, cells fail to repopulate the B and T cell population as well as do wild type cells
• fewer cells undergo the switch from IgM to IgG1 or IgG3 compared to in wild type mice
• however, there is no increase in Igh chromosomal aberrations
• the number of mature and re-circulating B cells is decreased compared to in wild-type mice
• however, the numbers of pro- and pre-B cells is normal




Genotype
MGI:5306351
cn30
Allelic
Composition
Kitltm2.1Sjm/Kitltm2.2Sjm
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: BALB/cJ * C57BL * CBA/Ca * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm2.1Sjm mutation (1 available); any Kitl mutation (51 available)
Kitltm2.2Sjm mutation (0 available); any Kitl mutation (51 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• exhibit normal blood cell counts, bone marrow composition, bone marrow and spleen cellularity, and reconstitution capacity
• 2-fold as in Kitltm2.2Sjm heterozygotes in the bone marrow




Genotype
MGI:5661695
cn31
Allelic
Composition
Cdh5tm8Dvst/Cdh5tm8Dvst
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh5tm8Dvst mutation (0 available); any Cdh5 mutation (20 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
N
• mice are viable and fertile and show no significant differences in fetal liver weight and cellularity at E13.5 relative to controls, indicating normal hematopoietic colonization of the fetal liver




Genotype
MGI:5314234
cn32
Allelic
Composition
Syktm1.1Nns/Syktm1.1Nns
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syktm1.1Nns mutation (0 available); any Syk mutation (15 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike null homozygotes, mice survive to adulthood

immune system
• at E14.5, mice exhibit blood-filled vessels unlike control mice
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

cardiovascular system
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

homeostasis/metabolism
• at E14.5




Genotype
MGI:5776602
cn33
Allelic
Composition
Piezo1tm2.1Apat/Piezo1tm2.1Apat
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piezo1tm2.1Apat mutation (1 available); any Piezo1 mutation (34 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• spleens appear dark and redder than controls
• spleens contain an increased number of mature, but not immature, Ter119+, CD71- red blood cells
• Ca2+ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca2+ is increased
• red blood cells exhibit increased osmotic fragility

homeostasis/metabolism
• Ca2+ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca2+ is increased
• red blood cells are overhydrated, however, discoid morphology is normal
• decreased plasma haptoglobin concentration
• Ca2+ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca2+ is increased

immune system
• spleens appear dark and redder than controls
• spleens contain an increased number of mature, but not immature, Ter119+, CD71- red blood cells




Genotype
MGI:5553469
cn34
Allelic
Composition
Tg(JAK2*V617F)FF1Rsko/0
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(JAK2*V617F)FF1Rsko mutation (0 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
• bones are pale at 20 weeks of age, suggesting decreased erythropoiesis
• erythroid TER-119+ cells are reduced in the bone marrow but a compensatory increase is seen in the spleen at 20 weeks of age
• myeloid cells are the predominant cell population in the bone marrow and are increased in the spleen at 20 weeks of age
• liver shows extramedullary hematopoiesis at 20 weeks of age with highly atypical megakaryocytes, but islands with myelopoeisis and erythropoiesis are also seen
• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
• hematopoietic cells, including megakaryocytes are seen in the lung at 20 weeks of age
• bone marrow shows hypercellularity with trilineage hyperplasia at 20 weeks of age
• colony assays of progenitors show extramedullary hematopoiesis with markedly increased erythroid and myeloid progenitor numbers in spleen
• collagen-based culture indicates a small increase in CFU-MK in bone marrow and a massive expansion of CFU-MK in the spleen
• increase in numbers of megakaryocytes in the spleen and bone marrow at 20 weeks of age, most with morphological abnormalities such as hyperchromatic, hyperlobulated nuclei, and bizarre nuclear configuration, and often forming clusters
• slight decrease in hemoglobin at 20 weeks of age but is normal at 10 weeks of age
• slight increase in neutrophils at 10 and 20 weeks of age
• thrombocytosis is seen at 10 weeks of age, with a massive increase in platelets at 20 weeks of age
• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
• destruction of normal splenic architecture by atypical hematopoiesis is seen in some sections of the spleen at 20 weeks of age
• seen at 20 weeks of age

immune system
• myeloid cells are the predominant cell population in the bone marrow and are increased in the spleen at 20 weeks of age
• slight increase in neutrophils at 10 and 20 weeks of age
• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
• the relative amount of B and T cells in the spleen and bone marrow is reduced at 20 weeks of age
• destruction of normal splenic architecture by atypical hematopoiesis is seen in some sections of the spleen at 20 weeks of age
• seen at 20 weeks of age

skeleton
• dilated sinusoids with intrasinusoidal hematopoiesis are seen in the bone marrow at 20 weeks of age
• myeloid cells are the predominant cell population in the bone marrow
• presence of myelofibrosis at 20 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Thrombocythemia 3; THCYT3 614521 J:134364




Genotype
MGI:5496262
cn35
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg/Gt(ROSA)26Sor+
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg mutation (0 available); any Gt(ROSA)26Sor mutation (329 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice do not show any abnormalities




Genotype
MGI:5564914
cn36
Allelic
Composition
Bcl11atm1Pwt/Bcl11atm1Pwt
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation (0 available); any Bcl11a mutation (15 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• granulocytes, T cells, macrophage conventional dendritic cells and dendritic cell progenitors not affected in spleen and bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
• about a 2-fold decrease in the bone marrow

immune system
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• also reduced in the spleen but not as severely as in the bone marrow
• 10- to 50-fold reduction in bone marrow at 6 weeks of age
• proportionate to the loss of plasmacytoid dendritic cell in bone marrow and spleen
• following infection with human HSV strain 17

homeostasis/metabolism
• following infection with human HSV strain 17




Genotype
MGI:5438280
cn37
Allelic
Composition
Idh1tm2Mak/Idh1tm2Mak
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Idh1tm2Mak mutation (0 available); any Idh1 mutation (11 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hematopoietical parameters in peripheral blood and normal bone marrow cell numbers
• increase in common lymphocyte progenitor cells in the bone marrow and spleen
• increase in megakaryocyte-erythroid progenitors in the spleen
• increase in LSK and lineage-restricted progenitors in the bone marrow and spleen
• increase in LK in the spleen




Genotype
MGI:4942368
cn38
Allelic
Composition
Tg(Kit*D814V)3Roer/0
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Kit*D814V)3Roer mutation (0 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• similar to the phenotype in mice carrying Tg(CMV-cre)1Cgn and Tg(Kit*D814V)3Roer




Genotype
MGI:4942367
cn39
Allelic
Composition
Tg(Kit*D814V)1Roer/0
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Kit*D814V)1Roer mutation (0 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• similar to the phenotype in mice carrying Tg(CMV-cre)1Cgn and Tg(Kit*D814V)1Roer




Genotype
MGI:5496264
cn40
Allelic
Composition
Gt(ROSA)26Sortm2(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(CAG-PSTPIP1*)Dtg mutation (0 available); any Gt(ROSA)26Sor mutation (329 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal behavior

growth/size/body
N
• mice exhibit normal body weight

immune system
N
• mice produce normal levels of proinflammatory cytokines when provoked with inflammasome-activating stimuli




Genotype
MGI:5301602
cn41
Allelic
Composition
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rc3h1tm1.1Mass mutation (0 available); any Rc3h1 mutation (22 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Increased spleen size in Rc3h1tm1.1Mass/Rc3h1tm1.1MassTg(Vav1-icre)A2Kio/0 mice

immune system
N
• mice exhibit normal T cell development and autoimmunity
• in the bone marrow
• immature and re-circulating B cells
• increased numbers in the spleen
• 1.5-fold but not as severe as in Rc3h1san homozygotes
• 1.5-fold
• mice exhibit increased spontaneous germinal center formation compared with control mice

hematopoietic system
• in the bone marrow
• immature and re-circulating B cells
• increased numbers in the spleen
• 1.5-fold but not as severe as in Rc3h1san homozygotes
• 1.5-fold
• mice exhibit increased spontaneous germinal center formation compared with control mice




Genotype
MGI:5604905
cn42
Allelic
Composition
Jagn1tm1c(EUCOMM)Hmgu/Jagn1tm1c(EUCOMM)Hmgu
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jagn1tm1c(EUCOMM)Hmgu mutation (0 available); any Jagn1 mutation (6 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• neutrophils show reduced numbers of primary and secondary granules
• neutrophils show alterations in the glycosylation of proteins involved in cell adhesion and cytotoxicity
• however, mice exhibit normal numbers of neutrophils in the bone marrow, secondary lymphoid organs and blood
• neutrophils, but not macrophages and dendritic cells, exhibit impaired killing of Candida albicans
• neutrophils show decreased ability to release myeloperoxidase when challenged in vitro with Candida albicans
• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)
• recruitment of neutrophils to the peritoneal cavity following Candida albicans injection into the peritoneal cavity is reduced and mice show decreased recruitment of neutrophils to the kidney and lung 24 hours following systemic infection with Candida albicans, indicating that neutrophils cannot effectively migrate to the site of infection
• mice are unable to mount an efficient neutrophil-dependent immune response to the human fungal pathogen Candida albicans, showing increased weight loss, massively increased fungal burdens, severe multifocal tubulointerstitial nephritis, splenitis with expanded white pulp, diffuse inflammatory infiltrations into the liver and lungs, and decreased TNF-alpha levels in the serum and intraperitonal lavage and succumb earlier to Candida albicans infection
• treatment with granulocyte/macrophage colony-stimulating factor (GM-CSF) protects mutants from weight loss, rescues the neutrophil recruitment defects and increases survival after Candida albicans challenge

cellular
• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)

hematopoietic system
• neutrophils show reduced numbers of primary and secondary granules
• neutrophils show alterations in the glycosylation of proteins involved in cell adhesion and cytotoxicity
• however, mice exhibit normal numbers of neutrophils in the bone marrow, secondary lymphoid organs and blood
• neutrophils, but not macrophages and dendritic cells, exhibit impaired killing of Candida albicans
• neutrophils show decreased ability to release myeloperoxidase when challenged in vitro with Candida albicans
• in vitro assays show a migratory defect in neutrophils in response to the chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLP)
• recruitment of neutrophils to the peritoneal cavity following Candida albicans injection into the peritoneal cavity is reduced and mice show decreased recruitment of neutrophils to the kidney and lung 24 hours following systemic infection with Candida albicans, indicating that neutrophils cannot effectively migrate to the site of infection




Genotype
MGI:5527435
cn43
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata mutation (0 available); any Gt(ROSA)26Sor mutation (329 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are observed at P10

hematopoietic system
• disturbed hematopoietic development in adult hematopoietic progenitor cells
• severe in some mice
• reduced total number of colony forming units from bone marrow cells




Genotype
MGI:5295638
cn44
Allelic
Composition
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Vav1-icre)A2Kio/0
Genetic
Background
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (1 available); any Atg7 mutation (20 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduction in most myeloid progenitors
• numbers of myeloid subsets CD11b+Gr1- and CD11b-Gr1+ are reduced in blood and decrease further over time
• overall bone marrow cell count is reduced
• common lymphoid progenitors (Lin-Flt3HighIL7RaHighSca-1Lowc-KitLow) are reduced in mutants
• numbers of CCR9+ lymphoid-primed multipotent progenitors are reduced in the bone marrow of mutants
• mutant LSK (Lin-Sca-1+c-Kit+) cells accumulate mitochondria, mitochondrial superoxide, and DNA damage and exhibit increased levels of apoptosis and proliferation
• numbers of hematopoietic stem cells are reduced in all mutants, regardless of disease progression
• absolute numbers of LSK (Lin-Sca-1+c-Kit+) cells significantly increased in asymptomatic 7 week old mutants, however as they develop symptoms, the frequency of LSK cells falls to wild-type levels
• the Lin-Sca-1-c-Kit+ (LK) compartment, containing more mature hematopoietic progenitors, is decreased
• numbers of CD11b+Gr1+ cells are increased in the blood at 5 and 6 weeks of age but then decrease to below wild-type levels at 8 weeks of age
• CD11b+Gr1+ cells in the spleen and bone marrow are increased and show higher proliferation rates
• mutants exhibit presence of atypical myeloid infiltrates in a wide range of organs
• mutants are cytopenic for all blood leukocyte populations except for CD11b+Gr1+ cells
• absolute cell counts of B cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• immature NK cells (Lin-CD3-CD122+NK1.1+DX5+) are depleted in the bone marrow
• absolute cell counts of NK cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• absolute cell counts of T cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• adult bone marrow cells from mutants transplanted together with CD45.1+ wild-type bone marrow cells into lethally irradiated wild-type hosts fail to contribute to reconstitution of cells in the hosts while in noncompetitive reconstitution experiments, lethally irradiated mice die within 4 weeks after transplantation with mutant bone marrow cells, indicating loss of hematopoietic stem cell activity

immune system
• numbers of CD11b+Gr1+ cells are increased in the blood at 5 and 6 weeks of age but then decrease to below wild-type levels at 8 weeks of age
• CD11b+Gr1+ cells in the spleen and bone marrow are increased and show higher proliferation rates
• mutants exhibit presence of atypical myeloid infiltrates in a wide range of organs
• mutants are cytopenic for all blood leukocyte populations except for CD11b+Gr1+ cells
• absolute cell counts of B cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• immature NK cells (Lin-CD3-CD122+NK1.1+DX5+) are depleted in the bone marrow
• absolute cell counts of NK cells are decreased in the peripheral blood of mutants and numbers drop steadily over time
• absolute cell counts of T cells are decreased in the peripheral blood of mutants and numbers drop steadily over time

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelodysplastic Syndrome; MDS 614286 J:176843




Genotype
MGI:5488604
cn45
Allelic
Composition
Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Tg(Vav1-icre)A2Kio/?
Genetic
Background
involves: CBA/Ca * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation (1 available); any Cxcl12 mutation (11 available)
Tg(Vav1-icre)A2Kio mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• normal cellularity and hematopoietic stem cell frequency
• bone marrow/spleen lineage composition is normal





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory