Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation
(1 available);
any
Mitf mutation
(72 available)
|
|
|
pigmentation
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• dorsal thickening of the retinal pigment epithelium observed at E13.5
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vision/eye
|
• dorsal thickening of the retinal pigment epithelium observed at E13.5
|
integument
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation
(1 available);
any
Mitf mutation
(72 available)
Mitftm1Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
|
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pigmentation
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• mice have a white coat color rarely with some dark spots
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vision/eye
N |
• mice have normal size eyes unlike the small eyes in mice with homozygous null alleles of this gene
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integument
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• mice have a white coat color rarely with some dark spots
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Allelic Composition |
Mitftm7Arnh/Mitfmi-vga9
|
|
Genetic Background |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation
(1 available);
any
Mitf mutation
(72 available)
Mitftm7Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
|
|
pigmentation
|
• intermediate coat color and spotting
|
integument
|
• intermediate coat color and spotting
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Allelic Composition |
Mitftm5Arnh/Mitfmi-vga9
|
|
Genetic Background |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation
(1 available);
any
Mitf mutation
(72 available)
Mitftm5Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
|
|
pigmentation
|
• very small white belly spots
|
integument
|
• very small white belly spots
|
Allelic Composition |
Mitftm4Arnh/Mitfmi-vga9
|
|
Genetic Background |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation
(1 available);
any
Mitf mutation
(72 available)
Mitftm4Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
|
|
pigmentation
|
• mice are almost completely white
|
integument
|
• mice are almost completely white
|
Allelic Composition |
Mitftm6Arnh/Mitfmi-vga9
|
|
Genetic Background |
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation
(1 available);
any
Mitf mutation
(72 available)
Mitftm6Arnh mutation
(0 available);
any
Mitf mutation
(72 available)
|
|
|
pigmentation
|
• intermediate coat color and spotting
|
integument
|
• intermediate coat color and spotting
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mortality/aging
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• mice die within 3 weeks of birth
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pigmentation
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• mice are white; similar to Mitfmi-vga9/mi-vga9 mice
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craniofacial
skeleton
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• severe, with complete filling of the bone marrow cavity with bony material
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vision/eye
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• similar to Mitfmi-vga9/mi-vga9 mice
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hematopoietic system
immune system
integument
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• mice are white; similar to Mitfmi-vga9/mi-vga9 mice
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growth/size/body
vision/eye
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• dorsal thickening observed at E13.5
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pigmentation
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• dorsal thickening observed at E13.5
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vision/eye
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• massive enlargement of the retinal pigment epithelium at E13.5
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pigmentation
|
• massive enlargement of the retinal pigment epithelium at E13.5
|
vision/eye
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• trans-differentiating retinal pigment epithelium cells generate differentiated retinal cells by birth
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pigmentation
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• trans-differentiating retinal pigment epithelium cells generate differentiated retinal cells by birth
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation
(1 available);
any
Mitf mutation
(72 available)
Tg(PAX6)77Ndha mutation
(0 available)
|
|
|
vision/eye
N |
• no thickening of the retinal pigment epithelium
|