About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mitfmi-vga9
transgenic insertion 9
MGI:2449916
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mitfmi-vga9/Mitfmi-vga9 involves: C57BL/6 * CBA MGI:4455017
ht2
Mitfmi-vga9/Mitftm1Arnh involves: 129S1/Sv * C3H/He * C57BL/6 MGI:3774180
ht3
Mitftm7Arnh/Mitfmi-vga9 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA MGI:5316595
ht4
Mitftm5Arnh/Mitfmi-vga9 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA MGI:5316592
ht5
Mitftm4Arnh/Mitfmi-vga9 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA MGI:5316593
ht6
Mitftm6Arnh/Mitfmi-vga9 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA MGI:5316594
cx7
Mitfmi-vga9/Mitfmi-vga9
Tfe3tm1Est/Tfe3tm1Est
either: (involves: 129/Sv * 129S1/Sv * C57BL/6 * CBA) or (involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA) MGI:3044415
cx8
Mitfmi-vga9/Mitf+
Pax6Sey-Neu/Pax6+
involves: C57BL/6 * CBA MGI:5316876
cx9
Mitfmi-vga9/Mitfmi-vga9
Pax6Sey-Neu/Pax6Sey-Neu
involves: C57BL/6 * CBA MGI:5316877
cx10
Mitfmi-vga9/Mitfmi-vga9
Pax6Sey-Neu/Pax6+
involves: C57BL/6 * CBA MGI:5316878
cx11
Mitfmi-vga9/Mitfmi-vga9
Tg(PAX6)77Ndha/Tg(PAX6)77Ndha
involves: C57BL/6 * CBA MGI:5316881


Genotype
MGI:4455017
hm1
Allelic
Composition
Mitfmi-vga9/Mitfmi-vga9
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• dorsal thickening of the retinal pigment epithelium observed at E13.5

vision/eye
• dorsal thickening of the retinal pigment epithelium observed at E13.5

integument




Genotype
MGI:3774180
ht2
Allelic
Composition
Mitfmi-vga9/Mitftm1Arnh
Genetic
Background
involves: 129S1/Sv * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Mitftm1Arnh mutation (0 available); any Mitf mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have a white coat color rarely with some dark spots

vision/eye
N
• mice have normal size eyes unlike the small eyes in mice with homozygous null alleles of this gene

integument
• mice have a white coat color rarely with some dark spots




Genotype
MGI:5316595
ht3
Allelic
Composition
Mitftm7Arnh/Mitfmi-vga9
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Mitftm7Arnh mutation (0 available); any Mitf mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• intermediate coat color and spotting

integument
• intermediate coat color and spotting




Genotype
MGI:5316592
ht4
Allelic
Composition
Mitftm5Arnh/Mitfmi-vga9
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Mitftm5Arnh mutation (0 available); any Mitf mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• very small white belly spots

integument
• very small white belly spots




Genotype
MGI:5316593
ht5
Allelic
Composition
Mitftm4Arnh/Mitfmi-vga9
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Mitftm4Arnh mutation (0 available); any Mitf mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice are almost completely white

integument
• mice are almost completely white




Genotype
MGI:5316594
ht6
Allelic
Composition
Mitftm6Arnh/Mitfmi-vga9
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Mitftm6Arnh mutation (0 available); any Mitf mutation (72 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• intermediate coat color and spotting

integument
• intermediate coat color and spotting




Genotype
MGI:3044415
cx7
Allelic
Composition
Mitfmi-vga9/Mitfmi-vga9
Tfe3tm1Est/Tfe3tm1Est
Genetic
Background
either: (involves: 129/Sv * 129S1/Sv * C57BL/6 * CBA) or (involves: 129S1/Sv * C57BL/6 * C57BL/6J * CBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Tfe3tm1Est mutation (1 available); any Tfe3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 3 weeks of birth

pigmentation
• mice are white; similar to Mitfmi-vga9/mi-vga9 mice

craniofacial

skeleton
• small osteoclasts
• severe, with complete filling of the bone marrow cavity with bony material

vision/eye
• similar to Mitfmi-vga9/mi-vga9 mice

hematopoietic system
• small osteoclasts

immune system
• small osteoclasts

integument
• mice are white; similar to Mitfmi-vga9/mi-vga9 mice

growth/size/body




Genotype
MGI:5316876
cx8
Allelic
Composition
Mitfmi-vga9/Mitf+
Pax6Sey-Neu/Pax6+
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Pax6Sey-Neu mutation (1 available); any Pax6 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• dorsal thickening observed at E13.5

pigmentation
• dorsal thickening observed at E13.5




Genotype
MGI:5316877
cx9
Allelic
Composition
Mitfmi-vga9/Mitfmi-vga9
Pax6Sey-Neu/Pax6Sey-Neu
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Pax6Sey-Neu mutation (1 available); any Pax6 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• massive enlargement of the retinal pigment epithelium at E13.5

pigmentation
• massive enlargement of the retinal pigment epithelium at E13.5




Genotype
MGI:5316878
cx10
Allelic
Composition
Mitfmi-vga9/Mitfmi-vga9
Pax6Sey-Neu/Pax6+
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Pax6Sey-Neu mutation (1 available); any Pax6 mutation (90 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• trans-differentiating retinal pigment epithelium cells generate differentiated retinal cells by birth

pigmentation
• trans-differentiating retinal pigment epithelium cells generate differentiated retinal cells by birth




Genotype
MGI:5316881
cx11
Allelic
Composition
Mitfmi-vga9/Mitfmi-vga9
Tg(PAX6)77Ndha/Tg(PAX6)77Ndha
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vga9 mutation (1 available); any Mitf mutation (72 available)
Tg(PAX6)77Ndha mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no thickening of the retinal pigment epithelium





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory