Analysis Tools
mortality/aging
|
• mice die within 3 weeks of birth
|
|
Allele Symbol Allele Name Allele ID |
Slc1a2tm1Kta targeted mutation 1, Kohichi Tanaka MGI:2449707 |
||||||||||||||||||||
| Summary |
4 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die within 3 weeks of birth
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• only about 50% survive until after 6 weeks of age
|
|
• subconvulsive doses of pentylenetetrazole (PTZ) lead to high voltage sharp wave bursts
|
|
• explosive running followed by maintained opisthotonus and straub tail
• death usually followed within a few minutes of seizure
• survivors of a seizure resumed normal behavior but developed additional seizures later leading to death
|
|
• although body weight was normal at birth, homozygous mice gained weight more slowly after birth
|
|
• subconvulsive doses of pentylenetetrazole (PTZ) lead to high voltage sharp wave bursts
|
|
• explosive running followed by maintained opisthotonus and straub tail
• death usually followed within a few minutes of seizure
• survivors of a seizure resumed normal behavior but developed additional seizures later leading to death
|
|
• 68% more brain edemas resulting from cold injury and size of edemas are much larger
|
|
• selective neuronal degeneration in the hippocampal CA1 in mice aged 4-8 weeks
|
|
• neuronal loss in the pyramidal layer of CA1 24 hours after brief (5 min) hippocampal ischemia leading to a build up of glutamate concentration
• by 4 days after ischemia, neuronal loss is seen throughout CA1 and CA3
• longer periods of ischemia are as damaging to wild-type mice as to homozygous mutants
|
|
• 68% more brain edemas resulting from cold injury and size of edemas are much larger
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• only have 65% glutamate transport when compared with wild-type mice in lumbar spinal cord and cerebral cortex
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• shortened lifespan (137 1.7 vs. 142 1.4 days)
|
|
• reduced glutamate transport in lumbar spinal cord at 120 days of age, compare with Tg(SOD1*G93A)1Gur mice
|
|
• increase in the rate of motor decline accompanied by earlier motor neuron loss
• accelerated motor neuron loss at 120 days of age, compare with Tg(SOD1*G93A)1Gur mice
• significant declines occur between 105 and 120 days (42% reduction) and between 120 days and end stage, compared with between 120 days and endstage (56%) in Tg(SOD1*G93A)1Gur mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||