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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Krit1tm1Dmar
targeted mutation 1, Douglas Marchuk
MGI:2449693
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Krit1tm1Dmar/Krit1tm1Dmar B6.129-Krit1tm1Dmar MGI:3029377


Genotype
MGI:3029377
hm1
Allelic
Composition
Krit1tm1Dmar/Krit1tm1Dmar
Genetic
Background
B6.129-Krit1tm1Dmar
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krit1tm1Dmar mutation (0 available); any Krit1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• generalized developmental arrest after E9.5 (J:88138)
• no embryos survived beyond day E11 (J:88138)
• generalized developmental arrest after E9.5 (J:88138)
• no embryos survived beyond day E11 (J:88138)

cardiovascular system
• loss of alpha-Sma staining in arteries of these mice indicates a failure to recruit arterial smooth muscle cells (J:88138)
• loss of alpha-Sma staining in arteries of these mice indicates a failure to recruit arterial smooth muscle cells (J:88138)
• narrowing of the rostral dorsal aorta was observed in E8.5 embryos (J:88138)
• narrowing of the rostral dorsal aorta was observed in E8.5 embryos (J:88138)
• intersomitic arteries become dilated shortly after their formation between E8.5 and E9.0 (J:88138)
• intersomitic arteries become dilated shortly after their formation between E8.5 and E9.0 (J:88138)
• narrowing of the branchial arteries was observed in E8.5 embryos (J:88138)
• narrowing of the branchial arteries was observed in E8.5 embryos (J:88138)
• dilation occurred throughout the aorta just distal to the heart and extend to most caudal regions of the E8.5 embryo (J:88138)
• dilation occurred throughout the aorta just distal to the heart and extend to most caudal regions of the E8.5 embryo (J:88138)
• abnormal vascular dilation noted at E8.5 (J:88138)
• vascular dilation was associated with an increased endothelial proliferation rate (J:88138)
• no difference in vascular apoptosis was observed (J:88138)
• no enlargement of the cardinal veins was observed (J:88138)
• no evidence of arteriovenous shunts (J:88138)
• abnormal vascular dilation noted at E8.5 (J:88138)
• vascular dilation was associated with an increased endothelial proliferation rate (J:88138)
• no difference in vascular apoptosis was observed (J:88138)
• no enlargement of the cardinal veins was observed (J:88138)
• no evidence of arteriovenous shunts (J:88138)
• cardiac development is normal prior to the development of vascular defects (J:88138)
• cardiac development is normal prior to the development of vascular defects (J:88138)

embryogenesis
• narrowing of the branchial arteries was observed in E8.5 embryos (J:88138)
• narrowing of the branchial arteries was observed in E8.5 embryos (J:88138)
• embryos retained a primitive yolk sac vascular network (J:88138)
• embryos retained a primitive yolk sac vascular network (J:88138)
• generalized developmental arrest after E9.5 (J:88138)
• generalized developmental arrest after E9.5 (J:88138)

craniofacial
• narrowing of the branchial arteries was observed in E8.5 embryos (J:88138)
• narrowing of the branchial arteries was observed in E8.5 embryos (J:88138)

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Cavernous Malformations; CCM 116860 J:88138





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory