Mouse Genome Informatics
hm1
    Krit1tm1Dmar/Krit1tm1Dmar
B6.129-Krit1tm1Dmar
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• generalized developmental arrest after E9.5
• no embryos survived beyond day E11

cardiovascular system
• loss of alpha-Sma staining in arteries of these mice indicates a failure to recruit arterial smooth muscle cells
• narrowing of the rostral dorsal aorta was observed in E8.5 embryos
• intersomitic arteries become dilated shortly after their formation between E8.5 and E9.0
• narrowing of the branchial arteries was observed in E8.5 embryos
• dilation occurred throughout the aorta just distal to the heart and extend to most caudal regions of the E8.5 embryo
• abnormal vascular dilation noted at E8.5
• vascular dilation was associated with an increased endothelial proliferation rate
• no difference in vascular apoptosis was observed
• no enlargement of the cardinal veins was observed
• no evidence of arteriovenous shunts
• cardiac development is normal prior to the development of vascular defects

embryogenesis
• narrowing of the branchial arteries was observed in E8.5 embryos
• embryos retained a primitive yolk sac vascular network
• generalized developmental arrest after E9.5

craniofacial
• narrowing of the branchial arteries was observed in E8.5 embryos

Mouse Models of Human Disease
OMIM IDRef(s)
Cerebral Cavernous Malformations; CCM 116860 J:88138