Analysis Tools
mortality/aging
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• generalized developmental arrest after E9.5
• no embryos survived beyond day E11
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cardiovascular system
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• loss of alpha-Sma staining in arteries of these mice indicates a failure to recruit arterial smooth muscle cells
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• narrowing of the rostral dorsal aorta was observed in E8.5 embryos
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• intersomitic arteries become dilated shortly after their formation between E8.5 and E9.0
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• narrowing of the branchial arteries was observed in E8.5 embryos
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• abnormal vascular dilation noted at E8.5
• vascular dilation was associated with an increased endothelial proliferation rate
• no difference in vascular apoptosis was observed
• no enlargement of the cardinal veins was observed
• no evidence of arteriovenous shunts
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dilated aorta
(
J:88138
)
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• dilation occurred throughout the aorta just distal to the heart and extend to most caudal regions of the E8.5 embryo
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• cardiac development is normal prior to the development of vascular defects
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embryo
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• narrowing of the branchial arteries was observed in E8.5 embryos
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• generalized developmental arrest after E9.5
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• embryos retained a primitive yolk sac vascular network
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craniofacial
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• narrowing of the branchial arteries was observed in E8.5 embryos
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