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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pck1tm1.1Mgn
targeted mutation 1.1, Mark A Magnuson
MGI:2449283
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pck1tm1.1Mgn/Pck1tm1.1Mgn involves: 129S6/SvEvTac MGI:3029208
cn2
Pck1tm1.1Mgn/Pck1tm1.1Mgn
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129S6/SvEvTac MGI:3029211


Genotype
MGI:3029208
hm1
Allelic
Composition
Pck1tm1.1Mgn/Pck1tm1.1Mgn
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pck1tm1.1Mgn mutation (1 available); any Pck1 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable and fertile; normal expression of the floxed gene was noted




Genotype
MGI:3029211
cn2
Allelic
Composition
Pck1tm1.1Mgn/Pck1tm1.1Mgn
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pck1tm1.1Mgn mutation (1 available); any Pck1 mutation (47 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• hepatic glycogen content was decreased at birth, reduced in older mutant animals and was depleted after a 24 hour fast
• hepatic triglyceride levels were increased by 94% after a 24 hour fast

liver/biliary system
• after a 24 hour fast, the liver mass was increased by 71% over controls
• liver weight was increased by 18%
• hepatic glycogen content was decreased at birth, reduced in older mutant animals and was depleted after a 24 hour fast
• hepatic triglyceride levels were increased by 94% after a 24 hour fast

growth/size/body
• after a 24 hour fast, the liver mass was increased by 71% over controls
• liver weight was increased by 18%





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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory