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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TIE2-lacZ)182Sato
transgene insertion 182, Thomas N Sato
MGI:2449204
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Apoetm1Unc/Apoetm1Unc
Gja5tm1Mchn/Gja5tm1Mchn
Tg(TIE2-lacZ)182Sato/0
involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:4818410
cx2
Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(TIE2-lacZ)182Sato/?
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:3836582


Genotype
MGI:4818410
cn1
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Gja5tm1Mchn/Gja5tm1Mchn
Tg(TIE2-lacZ)182Sato/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (145 available)
Gja5tm1Mchn mutation (0 available); any Gja5 mutation (18 available)
Tg(TIE2-lacZ)182Sato mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal mean arterial pressure, heart rate, and endothelium-dependent vasomotor responses to KCl and norepinephrine
• whether fed a high-fat or standard diet, mice exhibit increased lipid staining in the thoracoabdominal aortas compared with Apoetm1Unc homozygotes
• whether fed a high-fat or standard diet, mice exhibit accelerated atherosclerosis compared with Apoetm1Unc homozygotes

immune system
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes

respiratory system
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes

hematopoietic system
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes




Genotype
MGI:3836582
cx2
Allelic
Composition
Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(TIE2-lacZ)182Sato/?
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation (1 available); any Nfatc3 mutation (70 available)
Nfatc4tm1Jmk mutation (1 available); any Nfatc4 mutation (36 available)
Tg(TIE2-lacZ)182Sato mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced number of smooth muscle cells in the dorsal aorta but no hemorrhage





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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory