Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfiatm1Rmg mutation
(1 available);
any
Nfia mutation
(28 available)
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Absence of corpus callosum in Nfiatm1Rmg/Nfiatm1Rmg mice
mortality/aging
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• more than 90% die postnatally
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nervous system
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• although callosal axons approach the midline, they fail to cross and extend aberrantly into the septum
• overlap of the axons in the corpus callosum and fornix and the corpus callosum and the hippocampal commissure
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• sling cells, which contribute to the development of the corpus callosum, are generated but migrate abnormally into the septum and do not form a sling
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• hippocampal commissure is absent or reduced
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• glia within the hippocampus, particularly the dentate gyrus and the fimbria are reduced
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• glia within the indusium griseum and the glial wedge are greatly reduced or absent
• glia within the hippocampus, particularly the dentate gyrus and the fimbria are reduced
• formation of the midline zipper glial population is disrupted, with glia either absent or shifted position
• glial tunnel is greatly reduced surrounding a smaller anterior commissure
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cellular
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• although callosal axons approach the midline, they fail to cross and extend aberrantly into the septum
• overlap of the axons in the corpus callosum and fornix and the corpus callosum and the hippocampal commissure
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfiatm1Rmg mutation
(1 available);
any
Nfia mutation
(28 available)
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Hydrocephalus in Nfiatm1Rmg/Nfiatm1Rmg mice
mortality/aging
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• about 95% die within 2 weeks of birth, with most dying on the day of birth
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growth/size/body
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• the rare survivors have a domed head, however this phenotype diminishes with time and adults appear relatively normal
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• the rare survivors are runted for the first two weeks of life
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nervous system
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• survivors display hydrocephalus, however this phenotype diminishes with time in most mutants except for a few rare adults that exhibit severe hydrocephalus
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• rare adults show dilation of the lateral ventricles
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• rare adults show dilation of the third ventricles
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behavior/neurological
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• rare surviving mice possess a tremor
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reproductive system
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• surviving females have low fecundity but are able to give birth and suckle young
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• adult males appear sterile, however histological examination of testes reveals no gross abnormalities
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craniofacial
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• the rare survivors have a domed head, however this phenotype diminishes with time and adults appear relatively normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfiatm1Rmg mutation
(1 available);
any
Nfia mutation
(28 available)
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Spectrum of kidney histology in Nfiatm1Rmg/Nfiatm1Rmg newborns
nervous system
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• 66% of newborns exhibit syringomyelia that is manifested as an enlarged central canal and confined to the lumbar region
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renal/urinary system
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• 68% of newborns display agenesis, dysplastic, cystic, or duplex kidneys
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• two mice that survive to P16 develop severe hydronephrosis
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• some newborns exhibit bilateral renal agenesis
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• newborns exhibit duplication and dilatation of the ureter at the ureteropelvic junction
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• newborns exhibit duplication and dilatation of the ureter at the ureteropelvic junction
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growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfiatm1Rmg mutation
(1 available);
any
Nfia mutation
(28 available)
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mortality/aging
nervous system
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• at P17, mice exhibit a deformed foliation pattern whereby fissures are reduced in depth and lobules are either stunted or poorly defined
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• at P17, dendrite formation is dramatically impaired on cerebrellar granule neurons (GCNs) through out the inner granule layer of more anterior lobules
• GCN nuclei are observed in the molecular layer
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• at P17, molecular layer axons are extremely short through both anterior and posterior aspects of the vermis
• GCN nuclei are observed in the molecular layer
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Allelic
Composition |
Nfiatm1Rmg/Nfia+
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Genetic
Background |
involves: 129P2/OlaHsd * Black Swiss |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfiatm1Rmg mutation
(1 available);
any
Nfia mutation
(28 available)
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cellular
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• loss of heterozygous progeny is seen only when the mutant allele is transmitted from the female parent, suggesting a maternal effect
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Allelic
Composition |
Nfiatm1Rmg/Nfia+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfiatm1Rmg mutation
(1 available);
any
Nfia mutation
(28 available)
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Ureter defects in Nfiatm1Rmg/Nfiatm1Rmg and Nfiatm1Rmg/Nifia+ mice
renal/urinary system
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• 22% of newborns exhibit hydronephrosis
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• newborns exhibit duplication and dilatation of the ureter at the ureteropelvic junction
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• newborns exhibit duplication and dilatation of the ureter at the ureteropelvic junction
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• some newborns exhibit dilation of the ureterovesical junction
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfiatm1Rmg mutation
(1 available);
any
Nfia mutation
(28 available)
Tg(Hoxb7-EGFP)33Cos mutation
(1 available)
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Nfiatm1Rmg/Nfia+ Tg(Hoxb7-EGFP)33Cos and Nfiatm1Rmg/Nfiatm1Rmg Tg(Hoxb7-EGFP)33Cos mice have ureteral defects
renal/urinary system
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• 33% of mutants exhibit ureteral development abnormalities, that include proximal flexion of the ureter and ureter dilation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfiatm1Rmg mutation
(1 available);
any
Nfia mutation
(28 available)
Tg(Hoxb7-EGFP)33Cos mutation
(1 available)
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Nfiatm1Rmg/Nfia+ Tg(Hoxb7-EGFP)33Cos and Nfiatm1Rmg/Nfiatm1Rmg Tg(Hoxb7-EGFP)33Cos mice have ureteral defects
renal/urinary system
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• 22% exhibit ureteral development abnormalities that include ureter dilation and partial ureteral duplication
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Analysis Tools