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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTFLPe)9205Dym
transgene insertion 9205, Susan Dymecki
MGI:2448985
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
En1tm2(cre)Wrst/En1+
Tg(ACTFLPe)9205Dym/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL MGI:4412289
cn2
 		Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tg(ACTFLPe)9205Dym/0
Tg(Pcp2-cre)2Mpin/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL MGI:4412292
cn3
 		Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tg(ACTFLPe)9205Dym/0
Tg(Atoh1-cre)1Bfri/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:4412287
cn4
 		Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
Tg(ACTFLPe)9205Dym/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:4412288
cn5
 		Tie1tm1Geno/Tie1tm1Geno
Tg(ACTFLPe)9205Dym/0 		involves: C57BL/6 * ICR * SJL MGI:4454553


Genotype
MGI:4412289
cn1
Allelic
Composition		 Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
En1tm2(cre)Wrst/En1+
Tg(ACTFLPe)9205Dym/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (32 available)
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(ACTFLPe)9205Dym mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4412292
cn2
Allelic
Composition		 Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tg(ACTFLPe)9205Dym/0
Tg(Pcp2-cre)2Mpin/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(ACTFLPe)9205Dym mutation (7 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
tremors ( J:154944 )
• mild tremors during motion




Genotype
MGI:4412287
cn3
Allelic
Composition		 Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tg(ACTFLPe)9205Dym/0
Tg(Atoh1-cre)1Bfri/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(ACTFLPe)9205Dym mutation (7 available)
Tg(Atoh1-cre)1Bfri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:154944 )
• aberrant foot print angles, irregular and reduced stride lengths

nervous system
abnormal synaptic vesicle recycling ( J:154944 )
• parallel fibers accumulate unreleased synaptic vesicles unlike in wild-type cells
abnormal excitatory postsynaptic currents ( J:154944 )
• stimulation of parallel fibers fails to stimulate an excitatory postsynaptic current (EPSC) unlike in similarly treated wild-type mice
• however, extremely high stimulus intensities evoke an EPSC and stimulated parallel fibers propagate action potentials normally

hearing/vestibular/ear
abnormal ear physiology ( J:154944 )
• mice exhibit auditory defects




Genotype
MGI:4412288
cn4
Allelic
Composition		 Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
Tg(ACTFLPe)9205Dym/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(ACTFLPe)9205Dym mutation (7 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4454553
cn5
Allelic
Composition		 Tie1tm1Geno/Tie1tm1Geno
Tg(ACTFLPe)9205Dym/0
Genetic
Background		 involves: C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTFLPe)9205Dym mutation (7 available)
Tie1tm1Geno mutation (0 available); any Tie1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:159507 )
N
• mice exhibit normal lymphangiogenesis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory