Phenotypes associated with this allele
Allelic Composition |
Tg(Msmb-TAg)186-3Xuan/0
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Genetic Background |
either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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neoplasm
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• 13% incidence of carcinoma, detectable by the age of 24-36 weeks with only 4/12 mice showing moderately differentiated adenocarcionma
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• rapid and uncontrolled tumor development in late age groups, compared to the steadily prolonged cancer development seen right after puberty in Msmbtm1Xuan mutant mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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neoplasm
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• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks
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• by 24 weeks, some high grade prostatic intraepithelial neoplasia foci showed microinvasion of the stroma, however no distant metastasis was found
• well-differentiated pancreatic cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 40% of transgenic mice and by 32 weeks or later, pancreatic cancer was detected in 100% of mice
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endocrine/exocrine glands
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• detected prostate hyperplasia by 10 weeks of age
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reproductive system
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• detected prostate hyperplasia by 10 weeks of age
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