Mouse Genome Informatics
tg1
    Tg(Msmb-TAg)186-3Xuan/0
either: (involves: C57BL/6 * CBA) or (involves C57BL/6 * CBA * CD-1)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• 13% incidence of carcinoma, detectable by the age of 24-36 weeks with only 4/12 mice showing moderately differentiated adenocarcionma
• rapid and uncontrolled tumor development in late age groups, compared to the steadily prolonged cancer development seen right after puberty in Msmbtm1Xuan mutant mice


Mouse Genome Informatics
tg2
    Tg(Msmb-TAg)186-3Xuan/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks
• by 24 weeks, some high grade prostatic intraepithelial neoplasia foci showed microinvasion of the stroma, however no distant metastasis was found
• well-differentiated pancreatic cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 40% of transgenic mice and by 32 weeks or later, pancreatic cancer was detected in 100% of mice

endocrine/exocrine glands
• detected prostate hyperplasia by 10 weeks of age (J:80313)

reproductive system
• detected prostate hyperplasia by 10 weeks of age (J:80313)

Mouse Models of Human Disease
OMIM IDRef(s)
Prostate Cancer 176807 J:80313