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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Msmb-TAg)186-3Xuan
transgene insertion 186-3, JW Xuan
MGI:2448149
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Msmb-TAg)186-3Xuan/0 either: (involves: C57BL/6 * CBA) or (involves C57BL/6 * CBA * CD-1) MGI:3574634
tg2
Tg(Msmb-TAg)186-3Xuan/0 involves: C57BL/6 * CBA MGI:3574638


Genotype
MGI:3574634
tg1
Allelic
Composition
Tg(Msmb-TAg)186-3Xuan/0
Genetic
Background
either: (involves: C57BL/6 * CBA) or (involves C57BL/6 * CBA * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 13% incidence of carcinoma, detectable by the age of 24-36 weeks with only 4/12 mice showing moderately differentiated adenocarcionma
• rapid and uncontrolled tumor development in late age groups, compared to the steadily prolonged cancer development seen right after puberty in Msmbtm1Xuan mutant mice




Genotype
MGI:3574638
tg2
Allelic
Composition
Tg(Msmb-TAg)186-3Xuan/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks
• by 24 weeks, some high grade prostatic intraepithelial neoplasia foci showed microinvasion of the stroma, however no distant metastasis was found
• well-differentiated pancreatic cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 40% of transgenic mice and by 32 weeks or later, pancreatic cancer was detected in 100% of mice

endocrine/exocrine glands
• detected prostate hyperplasia by 10 weeks of age

reproductive system
• detected prostate hyperplasia by 10 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Prostate Cancer 176807 J:80313





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory