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Allele Symbol Allele Name Allele ID |
Tg(Msmb-TAg)183-2Xuan transgene insertion 183-2, JW Xuan MGI:2448148 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 33% incidence of carcinoma, which was distributed throughout all age groups, with no moderately differentiated prostate cancer
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• rapid and uncontrolled tumor development in late age groups, compared to the steadily prolonged cancer development seen in Msmbtm1Xuan mutant mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• moderately differentiated adenocarcinoma (prostate cancer) was detected by 16-19 weeks of age
• well-differentiated prostate cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 13% of transgenic mice and by 32 weeks or later, prostate cancer was detected in 40% of mice
• poorly differentiated prostate cancer started as early as 16 weeks of age and 8/10 poorly differentiated prostate cancers showed large visible tumors
• 2/3 of castrated mice showed visible, fair-sized carcinoma one month after castration, while 1/3 showed high grade prostatic intraepithelial neoplasia
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• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks
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• metastatic cells of prostatic origin were found in the lymph nodes with the lymph node cortex replaced with undifferentiated epithelial cells
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• detected prostate hyperplasia by 10 weeks of age, with a few mice showing an unexpected appearance of hyperplasia at 16 to 32 weeks of age
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• moderately differentiated adenocarcinoma (prostate cancer) was detected by 16-19 weeks of age
• well-differentiated prostate cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 13% of transgenic mice and by 32 weeks or later, prostate cancer was detected in 40% of mice
• poorly differentiated prostate cancer started as early as 16 weeks of age and 8/10 poorly differentiated prostate cancers showed large visible tumors
• 2/3 of castrated mice showed visible, fair-sized carcinoma one month after castration, while 1/3 showed high grade prostatic intraepithelial neoplasia
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• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks
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• transgenic mice with visible prostate tumors had enlarged renal lymph nodes
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• detected prostate hyperplasia by 10 weeks of age, with a few mice showing an unexpected appearance of hyperplasia at 16 to 32 weeks of age
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• moderately differentiated adenocarcinoma (prostate cancer) was detected by 16-19 weeks of age
• well-differentiated prostate cancer started by 24 weeks of age, mostly in the ventral and dorsolateral prostate lobes (not in the coagulation gland or seminal vesicles) and was detected in 13% of transgenic mice and by 32 weeks or later, prostate cancer was detected in 40% of mice
• poorly differentiated prostate cancer started as early as 16 weeks of age and 8/10 poorly differentiated prostate cancers showed large visible tumors
• 2/3 of castrated mice showed visible, fair-sized carcinoma one month after castration, while 1/3 showed high grade prostatic intraepithelial neoplasia
|
|
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• some mice exhibited low grade prostatic intraepithelial neoplasia at age 12-19 weeks, then gradually decreased to being unidentifiable at or after 28 weeks of age and some mice exhibited high grade prostatic intraepithelial neoplasia from 12-19 weeks
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| prostate cancer | DOID:10283 |
OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 |
J:80313 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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