About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrg1tm1Fej
targeted mutation 1, Frank E Jones
MGI:2448075
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nrg1tm1Fej/Nrg1tm1Fej involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:3530443
cn2
 		Nrg1tm1Fej/Nrg1tm1Fej
Neurod6tm1(cre)Kan/? 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3835559
cn3
 		Nrg1tm1Fej/Nrg1tm1Fej
Emx1tm1(cre)Krj/? 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:3835560
cn4
 		Nrg1tm1Fej/Nrg1tm1Fej
Tg(Nes-cre)1Kln/? 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3835561
cn5
 		Nrg1tm1Fej/Nrg1tm1Fej
Tg(Camk2a-cre)#Kln/? 		involves: 129P2/OlaHsd * CBA/J MGI:3835558


Genotype
MGI:3530443
hm1
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland growth during pregnancy ( J:81107 )
• a decrease in alveolar development in pregnant mice was observed at days 12.5-17 dpc, with the alveoli remaining condensed, suggesting a lactation defect
• at parturition, alveoli appreared distended compared to controls and the luminal epithelial cells appeared flat in shape compared to the cuboidal shape in controls, although secretory activity was apparent
• by 6 days postpartum, mammary gland morphology appeared similar to controls, indicating that the impairment of alveolar development was transient
• despite these defects, dams were able to support lactate and support litters

reproductive system
abnormal mammary gland growth during pregnancy ( J:81107 )
• a decrease in alveolar development in pregnant mice was observed at days 12.5-17 dpc, with the alveoli remaining condensed, suggesting a lactation defect
• at parturition, alveoli appreared distended compared to controls and the luminal epithelial cells appeared flat in shape compared to the cuboidal shape in controls, although secretory activity was apparent
• by 6 days postpartum, mammary gland morphology appeared similar to controls, indicating that the impairment of alveolar development was transient
• despite these defects, dams were able to support lactate and support litters

integument
abnormal mammary gland growth during pregnancy ( J:81107 )
• a decrease in alveolar development in pregnant mice was observed at days 12.5-17 dpc, with the alveoli remaining condensed, suggesting a lactation defect
• at parturition, alveoli appreared distended compared to controls and the luminal epithelial cells appeared flat in shape compared to the cuboidal shape in controls, although secretory activity was apparent
• by 6 days postpartum, mammary gland morphology appeared similar to controls, indicating that the impairment of alveolar development was transient
• despite these defects, dams were able to support lactate and support litters




Genotype
MGI:3835559
cn2
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Neurod6tm1(cre)Kan/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (17 available)
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• fully viable and comparable to wild-type controls
• cortex and hippocampus appear normal morphologically and immunohistochemically




Genotype
MGI:3835560
cn3
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Emx1tm1(cre)Krj/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• forebrain fully myelinated at 4 months of age
• no morphological or biochemical differences from wild-type controls




Genotype
MGI:3835561
cn4
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Tg(Nes-cre)1Kln/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (53 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• brain morphology normal at birth
abnormal Schwann cell morphology ( J:145464 )
• spinal cord ventral root Schwann cell development is blocked




Genotype
MGI:3835558
cn5
Allelic
Composition		 Nrg1tm1Fej/Nrg1tm1Fej
Tg(Camk2a-cre)#Kln/?
Genetic
Background		 involves: 129P2/OlaHsd * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Fej mutation (0 available); any Nrg1 mutation (53 available)
Tg(Camk2a-cre)#Kln mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• no developmental abnormalities in the cortex, hippocampus, or subcortical white matter
• no demyelination at older ages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory