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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Disp1icb
icbins
MGI:2448055
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Disp1icb/Disp1icb involves: 129/Sv * C57BL/6J * SWR MGI:3513052
hm2
Disp1icb/Disp1icb involves: C3HeB/FeJ * C57BL/6J MGI:2448059
ht3
Disp1icb/Disp1tm1Amc involves: 129X1/SvJ * C57BL/6J MGI:3052725
cn4
Disp1icb/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129/Sv * C57BL/6J * SWR MGI:3513048
cn5
Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Tg(Sox2-cre)1Amc/0
involves: 129/Sv * C57BL/6J * SWR MGI:3513053
cn6
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129X1/SvJ * C57BL/6J MGI:3054017
cx7
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
involves: 129X1/SvJ * C57BL/6J MGI:3052728
cx8
Disp1icb/Disp1icb
Ptch1tm1Mps/Ptch1tm1Mps
involves: C3HeB/FeJ * C57BL/6J MGI:2448060


Genotype
MGI:3513052
hm1
Allelic
Composition
Disp1icb/Disp1icb
Genetic
Background
involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die before E9.5

cardiovascular system

craniofacial
• gross defects in facial development are seen

embryo

limbs/digits/tail
• gross defects in limb development are seen

nervous system
• defects in neural development are seen

growth/size/body
• gross defects in facial development are seen




Genotype
MGI:2448059
hm2
Allelic
Composition
Disp1icb/Disp1icb
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos arrested at E9.0-E9.5 (J:79027)
• die at E9.0 (J:98216)

cardiovascular system
• embryos lacked asymmetrical heart looping

craniofacial
• embryos possessed abnormally shaped heads

embryo
• embryonic turning occurred in a randomized direction
• left-right randomization
• neural tube was dorsalized

homeostasis/metabolism

limbs/digits/tail
• embryos possessed relatively large forelimbs

nervous system
N
• intact notochord
• neural tube was dorsalized
• dorsalized spinal cord

growth/size/body
• embryos possessed abnormally shaped heads




Genotype
MGI:3052725
ht3
Allelic
Composition
Disp1icb/Disp1tm1Amc
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (23 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• misshapen or absent
• misshapen or absent
• loss of primary palate, premaxillary and nasal components
• severe losses of frontal component
• loss of upper incisors
• lack vomeronasal organs

endocrine/exocrine glands
• failed to develop

respiratory system
• lack vomeronasal organs
• nasopharyngeal airway narrowed or closed

skeleton
• misshapen or absent
• misshapen or absent
• loss of primary palate, premaxillary and nasal components
• severe losses of frontal component
• loss of upper incisors
• delayed differentiation in the cervical region

nervous system
• lack vomeronasal organs
• failed to develop

growth/size/body
• severe midline facial defects by E10.5
• loss of upper incisors
• lack vomeronasal organs




Genotype
MGI:3513048
cn4
Allelic
Composition
Disp1icb/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (23 available)
Disp1tm2Amc mutation (1 available); any Disp1 mutation (23 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
• fusion of the nasal pits
• facial midline defects are seen

skeleton

nervous system
• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type

embryo

respiratory system
• fusion of the nasal pits

cellular
• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type

growth/size/body
• facial midline defects are seen




Genotype
MGI:3513053
cn5
Allelic
Composition
Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Tg(Sox2-cre)1Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (23 available)
Shhtm1Amc mutation (1 available); any Shh mutation (26 available)
Shhtm5Amc mutation (0 available); any Shh mutation (26 available)
Tg(Sox2-cre)1Amc mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compound mutants die around birth unlike Disp1 single homozygotes which die before E9.5

craniofacial
• midline defects in the frontal nasal process are seen, however many of the developmental defects seen in Disp1 single homozygotes are rescued in the compound mutants




Genotype
MGI:3054017
cn6
Allelic
Composition
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (23 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (23 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• digit 2 is absent, all other digits are present




Genotype
MGI:3052728
cx7
Allelic
Composition
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (23 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (23 available)
Shhtm1Amc mutation (1 available); any Shh mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• no heart looping but normal embryo turning

nervous system
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors

craniofacial
• extreme proboscis-like nasal process

growth/size/body
• extreme proboscis-like nasal process

Mouse Models of Human Disease
OMIM ID Ref(s)
Holoprosencephaly 3; HPE3 142945 J:92058




Genotype
MGI:2448060
cx8
Allelic
Composition
Disp1icb/Disp1icb
Ptch1tm1Mps/Ptch1tm1Mps
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (23 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos arrested at E9.0-9.5

nervous system
• neural tube was ventralized

embryo
• neural tube was ventralized

growth/size/body
• heads of the embryos appeared truncated





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory