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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Disp1icb
icbins
MGI:2448055
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Disp1icb/Disp1icb involves: 129/Sv * C57BL/6J * SWR MGI:3513052
hm2
Disp1icb/Disp1icb involves: C3HeB/FeJ * C57BL/6J MGI:2448059
ht3
Disp1icb/Disp1tm1Amc involves: 129X1/SvJ * C57BL/6J MGI:3052725
cn4
Disp1icb/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129/Sv * C57BL/6J * SWR MGI:3513048
cn5
Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Tg(Sox2-cre)1Amc/0
involves: 129/Sv * C57BL/6J * SWR MGI:3513053
cn6
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
involves: 129X1/SvJ * C57BL/6J MGI:3054017
cx7
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
involves: 129X1/SvJ * C57BL/6J MGI:3052728
cx8
Disp1icb/Disp1icb
Ptch1tm1Mps/Ptch1tm1Mps
involves: C3HeB/FeJ * C57BL/6J MGI:2448060


Genotype
MGI:3513052
hm1
Allelic
Composition
Disp1icb/Disp1icb
Genetic
Background
involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die before E9.5 (J:94270)
• homozygotes die before E9.5 (J:94270)

cardiovascular system

craniofacial
• gross defects in facial development are seen (J:94270)
• gross defects in facial development are seen (J:94270)

embryogenesis

limbs/digits/tail
• gross defects in limb development are seen (J:94270)
• gross defects in limb development are seen (J:94270)

nervous system
• defects in neural development are seen (J:94270)
• defects in neural development are seen (J:94270)

growth/size/body
• gross defects in facial development are seen (J:94270)
• gross defects in facial development are seen (J:94270)




Genotype
MGI:2448059
hm2
Allelic
Composition
Disp1icb/Disp1icb
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos arrested at E9.0-E9.5 (J:79027)
• embryos arrested at E9.0-E9.5 (J:79027)
• die at E9.0 (J:98216)
• die at E9.0 (J:98216)

cardiovascular system
• embryos lacked asymmetrical heart looping (J:79027)
• embryos lacked asymmetrical heart looping (J:79027)

craniofacial
• embryos possessed abnormally shaped heads (J:79027)
• embryos possessed abnormally shaped heads (J:79027)

embryogenesis
• embryonic turning occurred in a randomized direction (J:79027)
• embryonic turning occurred in a randomized direction (J:79027)
• left-right randomization (J:98216)
• left-right randomization (J:98216)
• neural tube was dorsalized (J:79027)
• neural tube was dorsalized (J:79027)

homeostasis/metabolism

limbs/digits/tail
• embryos possessed relatively large forelimbs (J:79027)
• embryos possessed relatively large forelimbs (J:79027)

nervous system
N
• intact notochord (J:79027)
• intact notochord (J:79027)
• neural tube was dorsalized (J:79027)
• neural tube was dorsalized (J:79027)
• dorsalized spinal cord (J:98216)
• dorsalized spinal cord (J:98216)

growth/size/body
• embryos possessed abnormally shaped heads (J:79027)
• embryos possessed abnormally shaped heads (J:79027)




Genotype
MGI:3052725
ht3
Allelic
Composition
Disp1icb/Disp1tm1Amc
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• loss of primary palate, premaxillary and nasal components (J:92058)
• loss of primary palate, premaxillary and nasal components (J:92058)
• severe losses of frontal component (J:92058)
• severe losses of frontal component (J:92058)
• loss of upper incisors (J:92058)
• loss of upper incisors (J:92058)
• lack vomeronasal organs (J:92058)
• lack vomeronasal organs (J:92058)

endocrine/exocrine glands
• failed to develop (J:92058)
• failed to develop (J:92058)

respiratory system
• lack vomeronasal organs (J:92058)
• lack vomeronasal organs (J:92058)
• nasopharyngeal airway narrowed or closed (J:92058)
• nasopharyngeal airway narrowed or closed (J:92058)

skeleton
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• misshapen or absent (J:92058)
• loss of primary palate, premaxillary and nasal components (J:92058)
• loss of primary palate, premaxillary and nasal components (J:92058)
• severe losses of frontal component (J:92058)
• severe losses of frontal component (J:92058)
• delayed differentiation in the cervical region (J:92058)
• delayed differentiation in the cervical region (J:92058)

nervous system
• lack vomeronasal organs (J:92058)
• lack vomeronasal organs (J:92058)
• failed to develop (J:92058)
• failed to develop (J:92058)

growth/size/body
• severe midline facial defects by E10.5 (J:92058)
• severe midline facial defects by E10.5 (J:92058)
• loss of upper incisors (J:92058)
• loss of upper incisors (J:92058)
• lack vomeronasal organs (J:92058)
• lack vomeronasal organs (J:92058)




Genotype
MGI:3513048
cn4
Allelic
Composition
Disp1icb/Disp1tm2Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Disp1tm2Amc mutation (1 available); any Disp1 mutation (1 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
• fusion of the nasal pits (J:94270)
• fusion of the nasal pits (J:94270)
• facial midline defects are seen (J:94270)
• facial midline defects are seen (J:94270)

skeleton

nervous system
• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type (J:94270)
• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type (J:94270)

embryogenesis

respiratory system
• fusion of the nasal pits (J:94270)
• fusion of the nasal pits (J:94270)

cellular
• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type (J:94270)
• pMN and pV3 progenitor cells are found at the midline and are reduced in numbers to less than 10% wild-type (J:94270)

growth/size/body
• facial midline defects are seen (J:94270)
• facial midline defects are seen (J:94270)




Genotype
MGI:3513053
cn5
Allelic
Composition
Disp1icb/Disp1icb
Shhtm1Amc/Shhtm5Amc
Tg(Sox2-cre)1Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6J * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Shhtm1Amc mutation (1 available); any Shh mutation (25 available)
Shhtm5Amc mutation (0 available); any Shh mutation (25 available)
Tg(Sox2-cre)1Amc mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compound mutants die around birth unlike Disp1 single homozygotes which die before E9.5 (J:94270)
• compound mutants die around birth unlike Disp1 single homozygotes which die before E9.5 (J:94270)

craniofacial
• midline defects in the frontal nasal process are seen, however many of the developmental defects seen in Disp1 single homozygotes are rescued in the compound mutants (J:94270)
• midline defects in the frontal nasal process are seen, however many of the developmental defects seen in Disp1 single homozygotes are rescued in the compound mutants (J:94270)




Genotype
MGI:3054017
cn6
Allelic
Composition
Disp1icb/Disp1tm1Amc
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (1 available)
Shhtm1(EGFP/cre)Cjt mutation (1 available); any Shh mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• digit 2 is absent, all other digits are present (J:92504)
• digit 2 is absent, all other digits are present (J:92504)




Genotype
MGI:3052728
cx7
Allelic
Composition
Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Disp1tm1Amc mutation (0 available); any Disp1 mutation (1 available)
Shhtm1Amc mutation (1 available); any Shh mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• no heart looping but normal embryo turning (J:92058)
• no heart looping but normal embryo turning (J:92058)

nervous system
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors (J:92058)
• ventral midline of neural tube occupied by a reduced population of motor neuron progenitors (J:92058)

craniofacial
• extreme proboscis-like nasal process (J:92058)
• extreme proboscis-like nasal process (J:92058)

growth/size/body
• extreme proboscis-like nasal process (J:92058)
• extreme proboscis-like nasal process (J:92058)

Mouse Models of Human Disease
OMIM ID Ref(s)
Holoprosencephaly 3; HPE3 142945 J:92058




Genotype
MGI:2448060
cx8
Allelic
Composition
Disp1icb/Disp1icb
Ptch1tm1Mps/Ptch1tm1Mps
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disp1icb mutation (0 available); any Disp1 mutation (1 available)
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos arrested at E9.0-9.5 (J:79027)
• embryos arrested at E9.0-9.5 (J:79027)

nervous system
• neural tube was ventralized (J:79027)
• neural tube was ventralized (J:79027)

embryogenesis
• neural tube was ventralized (J:79027)
• neural tube was ventralized (J:79027)

growth/size/body
• heads of the embryos appeared truncated (J:79027)
• heads of the embryos appeared truncated (J:79027)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory