Mouse Genome Informatics
hm1
    Mmp20tm1Jdb/Mmp20tm1Jdb
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Enamel delaminates from the dentin surface in Mmp20tm1Jdb/Mmp20tm1Jdb mouse molars

craniofacial
• during enamel development, ameloblasts become progressively more disorganized
• disorganized enamel protein structure
• the enamel that normally surrounds the cusps of molars is virtually absent and only the cervical margin of the tooth has enamel
• the inner enamel layer shows a complete absence of the typical decussating rod pattern and enamel rod diameters are uneven

Mouse Models of Human Disease
OMIM IDRef(s)
Amelogenesis Imperfecta, Hypomaturation Type, Iia2; AI2A2 612529 J:80925