craniofacial

abnormal ameloblast morphology ( J:80925 )

• during enamel development, ameloblasts become progressively more disorganized

• disorganized enamel protein structure

• the enamel that normally surrounds the cusps of molars is virtually absent and only the cervical margin of the tooth has enamel

abnormal enamel rod pattern ( J:80925 )

• the inner enamel layer shows a complete absence of the typical decussating rod pattern and enamel rod diameters are uneven

delaminated enamel ( J:80925 )

reduced enamel thickness ( J:80925 )

Mouse Models of Human Disease		OMIM ID	Ref(s)
Amelogenesis Imperfecta, Hypomaturation Type, Iia2; AI2A2		612529	J:80925