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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mnx1tm4(cre)Tmj
targeted mutation 4, Thomas M Jessell
MGI:2447793
Summary 16 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Mnx1tm4(cre)Tmj/Mnx1+ involves: 129S1/Sv MGI:5484558
cn2
Dsptm1Efu/Dsptm1Efu
Mnx1tm4(cre)Tmj/Mnx1+
either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) MGI:5691408
cn3
Mnx1tm4(cre)Tmj/Mnx1+
Smn1tm1Cdid/Smn1tm1Cdid
Tg(SMN2)89Ahmb/0
involves: 129 * 129S1/Sv * C57BL/6 * FVB MGI:5318858
cn4
Mnx1tm4(cre)Tmj/Mnx1+
Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
involves: 129 * 129S1/Sv * C57BL/6 * SJL MGI:5619357
cn5
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3716107
cn6
Fgd4tm1Ics/Fgd4tm1Ics
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129S1/Sv MGI:5460883
cn7
Gt(ROSA)26Sortm1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129S1/Sv * 129S4/SvJae * BALB/cJ * C57BL/6 MGI:5484557
cn8
Gfra1tm2Jmi/Gfra1tm2Jmi
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129S1/Sv * 129X1/SvJ MGI:3783345
cn9
Dlg1tm1Rlh/Dlg1tm1Rlh
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3817234
cn10
Mnx1tm4(cre)Tmj/Mnx1+
Mycbp2tm1Adia/Mycbp2tm1Adia
involves: 129S1/Sv * C57BL/6 MGI:3760658
cn11
Mnx1tm4(cre)Tmj/Mnx1+
Tardbptm1.1Ckjs/Tardbptm1.2Cjks
involves: 129S1/Sv * C57BL/6J MGI:5513111
cn12
Mnx1tm4(cre)Tmj/Mnx1+
Rettm2(RET)Heno/Rettm2(RET)Heno
involves: 129S1/Sv * C57BL/6 * SJL MGI:3783346
cn13
Mnx1tm4(cre)Tmj/Mnx1+
Isl2tm1Arbr/Isl2+
involves: 129S7/SvEvBrd * C57BL/6J MGI:3583819
cn14
Lrp4tm1.1Line/Lrp4tm1.1Line
Mnx1tm4(cre)Tmj/Mnx1+
Tg(ACTA1-cre)79Jme/0
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL MGI:5440761
cn15
Lrp4tm1.1Line/Lrp4tm1.1Line
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * SJL MGI:5440760
cn16
Mnx1tm4(cre)Tmj/Mnx1+
Rettm2(RET)Heno/Rettm2(RET)Heno
involves: C57BL/6 * SJL MGI:3783344


Genotype
MGI:5484558
ht1
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• compared with Gt(ROSA)26Sortm1(CAG-PLS3,-GFP)Bwir heterozygotes

nervous system
• mice exhibit reduced endplate size compared with Gt(ROSA)26Sortm1(CAG-PLS3,-GFP)Bwir heterozygotes




Genotype
MGI:5691408
cn2
Allelic
Composition
Dsptm1Efu/Dsptm1Efu
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dsptm1Efu mutation (1 available); any Dsp mutation (44 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• seven days after quadriceps femoris nerve crush, axon outgrowth from lesion site is significantly less than in wild-type
• sciatic functional index (SFI), following sciatic nerve crush, is worse in mutant as compared to wild-type
• initial decline is similar, but recovery is slower and does not reach initial state of function after 35 days
• toe spreading is worse after crush as compared to wild-type
• compound muscle action potential (CMAP) is reduced following sciatic nerve crush and does not fully recover
• nerve conduction velocity (NCV) is reduced following sciatic nerve crush as compared to wild-type, but recovers by 35 days
• regeneration of motor fibers is delayed at 14 days and 28 days following quadriceps femoris nerve crush as compared to wild-type
• reduced number of motor fibers at 14 days and 28 days following quadriceps femoris nerve crush as compared to wild-type

cellular
• seven days after quadriceps femoris nerve crush, axon outgrowth from lesion site is significantly less than in wild-type




Genotype
MGI:5318858
cn3
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Smn1tm1Cdid/Smn1tm1Cdid
Tg(SMN2)89Ahmb/0
Genetic
Background
involves: 129 * 129S1/Sv * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
Smn1tm1Cdid mutation (0 available); any Smn1 mutation (60 available)
Tg(SMN2)89Ahmb mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival of 12 days

nervous system
N
• neuromuscular junctions are similar to controls in the intercostal and triangularis sterni muscles
• decrease in cardiac autonomic innervation
• in L3-L5 spinal cord sections but not in the cervical or thoracic regions

cardiovascular system
• end-stage mice display skipped or dropped beats
• at P9-P11
• at P9-P11

behavior/neurological
N
• ambulatory throughout life
• lateral instability of the hind limbs
• significantly improved righting response
• early in life
• outgrow this passive behavior after P6

growth/size/body

Mouse Models of Human Disease
OMIM ID Ref(s)
Spinal Muscular Atrophy, Type I; SMA1 253300 J:183080




Genotype
MGI:5619357
cn4
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic
Background
involves: 129 * 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
Rhot1tm1.1Jmsu mutation (0 available); any Rhot1 mutation (15 available)
Rhot1tm1.2Jmsu mutation (0 available); any Rhot1 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice do not exhibit any obvious phenotypes




Genotype
MGI:3716107
cn5
Allelic
Composition
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Ewsr1/Etv4)Arbr mutation (0 available); any Mapt mutation (401 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

cellular
• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination




Genotype
MGI:5460883
cn6
Allelic
Composition
Fgd4tm1Ics/Fgd4tm1Ics
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgd4tm1Ics mutation (0 available); any Fgd4 mutation (55 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• normal myelination of plantaris, quadriceps or saphenous nerves




Genotype
MGI:5484557
cn7
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-PLS3,-GFP)Bwir mutation (0 available); any Gt(ROSA)26Sor mutation (315 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• mice exhibit normalized muscle fiber size compared with Mnx1tm4(cre)Tmj heterozygotes

nervous system
N
• mice exhibit normalized endplate size compared with Mnx1tm4(cre)Tmj heterozygotes




Genotype
MGI:3783345
cn8
Allelic
Composition
Gfra1tm2Jmi/Gfra1tm2Jmi
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra1tm2Jmi mutation (0 available); any Gfra1 mutation (13 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• loss of small diameter but not large diameter axons in lumbar ventral roots and in distal medial gastrocnemius nerve




Genotype
MGI:3817234
cn9
Allelic
Composition
Dlg1tm1Rlh/Dlg1tm1Rlh
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlg1tm1Rlh mutation (1 available); any Dlg1 mutation (40 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit an 80% decrease in dendrite branches, a 50% reduction in overall tree size, a 50% reduction in average dendrite length and a 15% reduction in the length of the longest dendrite compared to in wild-type mice




Genotype
MGI:3760658
cn10
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Mycbp2tm1Adia/Mycbp2tm1Adia
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
Mycbp2tm1Adia mutation (0 available); any Mycbp2 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice are stillborn while others survive into adulthood and are fertile

nervous system
• mice exhibit neurofilament-rich sprouts that extend beyond normally innervated endplates

respiratory system
N
• diaphragms exhibit full innervation unlike in Phr1tm1.1Adia homozygotes




Genotype
MGI:5513111
cn11
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Tardbptm1.1Ckjs/Tardbptm1.2Cjks
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
Tardbptm1.1Ckjs mutation (0 available); any Tardbp mutation (26 available)
Tardbptm1.2Cjks mutation (0 available); any Tardbp mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• average lifespan of mutants showing amyotrophic lateral sclerosis-like phenotypes is 10 months

growth/size/body
• average weight is slightly lower at early birth than in controls and this difference becomes more pronounced with age, with a significant weight difference after 8 weeks of age
• while mutants show a peak of weight gain during 90-100 days of age, soon after this time, they begin to show weight loss

behavior/neurological
• abnormal hind limb clasping is seen after 13 weeks of age
• mutants show a deficiency in the rotarod test after 13 weeks of age

immune system
• microglia activation is seen in the lateroventral lumbar spinal cord

muscle
• more males than females develop amyotrophic lateral sclerosis-like phenotypes with a male/female ratio of 3:1

nervous system
• microglia activation is seen in the lateroventral lumbar spinal cord
• in the spinal cord
• accumulation of ubiquitinated proteins in the spinal cord motor neurons at 20 weeks of age
• progressive loss of motor neurons, with a 10% decrease of spinal cord motor neurons at 10 weeks of age and a large loss of ChAT-positive motor neurons at 20 weeks of age
• 46% and 25% reduction in alpha and gamma motor neurons, respectively, in the lumbar regions of the spinal cord at 20 weeks of age
• more males than females develop amyotrophic lateral sclerosis-like phenotypes with a male/female ratio of 3:1
• motor neuron loss, reactive astrocytosis, microglia activation and accumulation of polyubiquitinated proteins in the ventral horn

skeleton
• mutants exhibit kyphosis beginning at 20 weeks of age which becomes severe at 24 weeks

hematopoietic system
• microglia activation is seen in the lateroventral lumbar spinal cord




Genotype
MGI:3783346
cn12
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Rettm2(RET)Heno/Rettm2(RET)Heno
Genetic
Background
involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
Rettm2(RET)Heno mutation (0 available); any Ret mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• fusimotor axons are unaffected




Genotype
MGI:3583819
cn13
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Isl2tm1Arbr/Isl2+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2tm1Arbr mutation (1 available); any Isl2 mutation (8 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice lack motor neurons when examined from E12 to E16.9 (J:69623)




Genotype
MGI:5440761
cn14
Allelic
Composition
Lrp4tm1.1Line/Lrp4tm1.1Line
Mnx1tm4(cre)Tmj/Mnx1+
Tg(ACTA1-cre)79Jme/0
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4tm1.1Line mutation (0 available); any Lrp4 mutation (34 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
Tg(ACTA1-cre)79Jme mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• increased number and length of secondary or intramuscular branches with tertiary and quaternary branches
• secondary branches are longer than in Lrp4tm1.1Line/Lrp4tm1.1Line Tg(ACTA1-cre)79Jme mice
• nerve terminals are fragmented in diaphragm
• severely impaired formation
• almost undetectable in the diaphragm at E13.5
• fewer and smaller AChR clusters

homeostasis/metabolism
• soon after birth




Genotype
MGI:5440760
cn15
Allelic
Composition
Lrp4tm1.1Line/Lrp4tm1.1Line
Mnx1tm4(cre)Tmj/Mnx1+
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp4tm1.1Line mutation (0 available); any Lrp4 mutation (34 available)
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal neuromuscular synapse formation




Genotype
MGI:3783344
cn16
Allelic
Composition
Mnx1tm4(cre)Tmj/Mnx1+
Rettm2(RET)Heno/Rettm2(RET)Heno
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (18 available)
Rettm2(RET)Heno mutation (0 available); any Ret mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• absence of fusimotor nerve terminals
• loss of small diameter but not large diameter axons in lumbar ventral roots and in distal medial gastrocnemius nerve





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory