Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl2tm1Arbr mutation
(1 available);
any
Isl2 mutation
(28 available)
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
Nrg1tm3Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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mortality/aging
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• ~90% of mice die at birth, with phenotype similar to Nrg1tm1Cbm homozygous embryos
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nervous system
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• Schwann cells are absent from intramuscular motor axons between E13.5-E16.5
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• motor neurons are defasciculated and disorganized
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• in developing muscle, motor axons largely retract by birth; by E18.5, motor axons and terminals are absent
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• at diaphragm synapses, band of acetylcholine receptors (AChRs) is wider (17.5% of muscle length) than in wild-type muscle (7% of muscle length)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation
(0 available);
any
Isl1 mutation
(33 available)
Nrg1tm1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
Nrg1tm3Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
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muscle
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• mutants exhibit a defect in muscle spindle differentiation in the dorsal root ganglion and motor neurons
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nervous system
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• mutants exhibit a defect in muscle spindle differentiation in the dorsal root ganglion and motor neurons
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• selective absence of Schwann cells at E16.5 in adductor and gracilis muscles but not in other muscles
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• parvalbumin+ proprioceptive afferents are present in E16.5 hindlimb muscles and initiate contact with individual myofibers, but they do not develop annulospiral branches around the myofibers
• parvalbumin+ proprioceptive terminals at muscle spindles remain primitive and unbranched at E18.5
• however, survival and initial differentiation of proprioceptive afferent sensory neurons is not impaired
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm3Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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muscle
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• small diameter with degeneration of the outer capsule in tamoxifen-treated mice
• however, innervation is normal
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• in tamoxifen-treated mice
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behavior/neurological
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• tamoxifen-treated mice hang on to an inverted grid 3 to 4 times less than controls mice
• strongly impaired in a beam-walking test
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nervous system
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• small diameter with degeneration of the outer capsule in tamoxifen-treated mice
• however, innervation is normal
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• in tamoxifen-treated mice
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