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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxo1tm1Whb
targeted mutation 1, William H Biggs III
MGI:2447732
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxo1tm1Whb/Foxo1tm1Whb Not Specified MGI:3039414
ht2
 		Foxo1tm1Whb/Foxo1+ Not Specified MGI:3653867
cn3
 		Foxo1tm1Whb/Foxo1+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0 		involves: 129S4/SvJae * C57BL/6J * CBA/J MGI:3629034
cx4
 		Foxo1tm1Whb/Foxo1+
Irs2tm1Mfw/Irs2tm1Mfw 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3653870
cx5
 		Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insrtm1Dac 		involves: 129S4/SvJae * C57BL/6 MGI:3653868
cx6
 		Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insr+ 		involves: 129S4/SvJae * C57BL/6 MGI:3653869


Genotype
MGI:3039414
hm1
Allelic
Composition		 Foxo1tm1Whb/Foxo1tm1Whb
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal internal carotid artery morphology ( J:88638 )
• at E9.5 the branches of the internal carotid artery appear malformed
abnormal intersomitic vessel morphology ( J:88638 )
• at E9.5 the intersomitic vessels are abnormal compared to wild-type mice
absent vitelline blood vessels ( J:88638 )
• at E9.5 yolk sacs from homozygotes lacked blood vessels
delayed heart looping ( J:88638 )
• cardiac looping is retarded in homozygotes at E9.5
distended pericardium ( J:88638 )
• the pericardium distended in homozygotes at E9.5

embryo
absent vitelline blood vessels ( J:88638 )
• at E9.5 yolk sacs from homozygotes lacked blood vessels




Genotype
MGI:3653867
ht2
Allelic
Composition		 Foxo1tm1Whb/Foxo1+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased liver glycogen level ( J:79560 )
• slightly lower hepatic glycogen levels

liver/biliary system
decreased liver glycogen level ( J:79560 )
• slightly lower hepatic glycogen levels




Genotype
MGI:3629034
cn3
Allelic
Composition		 Foxo1tm1Whb/Foxo1+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (31 available)
Pdpk1tm1Maka mutation (0 available); any Pdpk1 mutation (138 available)
Tg(Ins2-cre)23Herr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating glucose level ( J:109010 )
• double mutants have improved blood glucose levels compared to Pdk1-deficient mice; glucose levels of 200-300 mg/dl are maintained in double mutants at 20-24 weeks
increased circulating insulin level ( J:109010 )
• plasma insulin level is significantly higher in double mutants compared to Pdk1-deficient mice

endocrine/exocrine glands
increased pancreatic beta cell number ( J:109010 )
• Foxo-haploinsufficiency results in a significant increase in beta cell number in double mutants
abnormal pancreas physiology ( J:109010 )
• insulin content of the pancreas in double mutant mice is 6-fold higher than in Pdk1-deficient mice; number of proliferating beta cells is much greater in double mutants compared to Pdk1-null mice




Genotype
MGI:3653870
cx4
Allelic
Composition		 Foxo1tm1Whb/Foxo1+
Irs2tm1Mfw/Irs2tm1Mfw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (31 available)
Irs2tm1Mfw mutation (1 available); any Irs2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:80826 )
N
• near normal pancreatic beta cell area due to improved beta cell proliferation

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:80826 )
N
• no diabetes and normal life span




Genotype
MGI:3653868
cx5
Allelic
Composition		 Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insrtm1Dac
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (31 available)
Insrtm1Dac mutation (2 available); any Insr mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:79560 )
• due to diabetic ketoacidosis

homeostasis/metabolism
decreased circulating glucose level ( J:79560 )
• 25% reduction in glucose levels relative to Insrtm1Dac homozygotes




Genotype
MGI:3653869
cx6
Allelic
Composition		 Foxo1tm1Whb/Foxo1+
Insrtm1Dac/Insr+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Whb mutation (0 available); any Foxo1 mutation (31 available)
Insrtm1Dac mutation (2 available); any Insr mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:79560 )
N
• normal insulin and glucose levels at both 2 and 6 months
• no diabetes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory