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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lta/Tnftm1Fda
targeted mutation 1, Francois Dautry
MGI:2447729
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lta/Tnftm1Fda/Lta/Tnftm1Fda involves: 129S1/Sv * 129X1/SvJ MGI:3768392
ht2
Lta/Tnftm1Fda/Tnf+ involves: 129S1/Sv * 129X1/SvJ MGI:3768394


Genotype
MGI:3768392
hm1
Allelic
Composition
Lta/Tnftm1Fda/Lta/Tnftm1Fda
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Fda mutation (0 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice do not produce detectable TNF-alpha in response to treatment with 100 ug LPS unlike wild-type mice (J:39519)
• mice do not produce detectable TNF-alpha in response to treatment with 100 ug LPS unlike wild-type mice (J:39519)
• mice survive doses of LPS and D-galactosamine that are three orders of magnitude higher than doses that would kill wild-type mice (J:39519)
• mice survive doses of LPS and D-galactosamine that are three orders of magnitude higher than doses that would kill wild-type mice (J:39519)
• bacterial load is 1000- and 50-fold higher than wild-type in the liver and spleen, respectively (J:39519)
• bacterial load is 1000- and 50-fold higher than wild-type in the liver and spleen, respectively (J:39519)




Genotype
MGI:3768394
ht2
Allelic
Composition
Lta/Tnftm1Fda/Tnf+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnftm1Fda mutation (0 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice produce 60-fold less TNF-alpha in response to treatment with 100 ug LPS than wild-type mice (J:39519)
• mice produce 60-fold less TNF-alpha in response to treatment with 100 ug LPS than wild-type mice (J:39519)
• at low doses of LPS and D-galactosamine lethality is 30% compared to 60% in wild-type mice and a high doses lethality is only increased slightly (J:39519)
• at low doses of LPS and D-galactosamine lethality is 30% compared to 60% in wild-type mice and a high doses lethality is only increased slightly (J:39519)
• bacterial load in the liver and spleen are 20- and 4-fold higher, respectively, than in wild-type mice but not as high as in homozygotes (J:39519)
• bacterial load in the liver and spleen are 20- and 4-fold higher, respectively, than in wild-type mice but not as high as in homozygotes (J:39519)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory