Mouse Genome Informatics
hm1
    Lta/Tnftm1Fda/Lta/Tnftm1Fda
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice do not produce detectable TNF-alpha in response to treatment with 100 ug LPS unlike wild-type mice
• mice survive doses of LPS and D-galactosamine that are three orders of magnitude higher than doses that would kill wild-type mice
• bacterial load is 1000- and 50-fold higher than wild-type in the liver and spleen, respectively


Mouse Genome Informatics
ht2
    Lta/Tnftm1Fda/Tnf+
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• mice produce 60-fold less TNF-alpha in response to treatment with 100 ug LPS than wild-type mice
• at low doses of LPS and D-galactosamine lethality is 30% compared to 60% in wild-type mice and a high doses lethality is only increased slightly
• bacterial load in the liver and spleen are 20- and 4-fold higher, respectively, than in wild-type mice but not as high as in homozygotes