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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Mpz)80.2Wra
transgene insertion 80.2, Lawrence Wrabetz
MGI:2447694
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Mpz)80.2Wra/0 involves: FVB/N MGI:2653547


Genotype
MGI:2653547
tg1
Allelic
Composition
Tg(Mpz)80.2Wra/0
Genetic
Background
involves: FVB/N
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced life span

behavior/neurological
• weak grip strength
• wobbling gait

growth/size/body

muscle
• atrophy of the paraspinal and hindlimb musculature
• leg muscles exhibit angulated and atrophic fibers suggestive of denervation

nervous system
• impairment of axon sorting by Schwann cells; this axon sorting defect is more evident at P5 and P14 than at P28
• sciatic nerve shows a mixture of fibers with thin myelin sheaths for the diameter of axon and fibers in which single Schwann cells ensheath axons, but form no myelin
• sciatic nerve development is arrested at the stage in which Schwann cells are segregating large axons away from bundles of mixed caliber axons
• severe dysmyelination resulting from a developmental delay, with rare evidence of active demyelination or axonal degeneration
• the motor branch (quadriceps) are more dysmyelinated than the sensory branch (saphenous) of femoral nerve by P10
• ventral roots are more dysmyelinated than dorsal roots
• P28 sciatic nerve exhibits hypomyelination and an increase in the number of Schwann cell nuclei
• nerve conduction velocities are reduced to about 2 m/s with temporal dispersion of the compound motor action potential, suggesting dysmyelinating neuropathy

reproductive system





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory