Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Mtc mutation
(0 available);
any
Hey2 mutation
(30 available)
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mortality/aging
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• exhibit decreased survival at 3 weeks of age due to cardiac defects
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cardiovascular system
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• the pulmonary artery shows thinner walls
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• the ascending aorta and descending aorta exhibit thinner walls
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• Background Sensitivity: observe an increased percentage of mitral valve abnormalities than on the BALB/c background
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• Background Sensitivity: all homozygotes show mitral valve leaflet thickening that is not seen in the mixed 129X1/SvJ and C57BL/6 background
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• Background Sensitivity: some homozygotes develop tricuspid valve abnormalities that are not observed in the mixed 129X1/SvJ and C57BL/6 background
• Background Sensitivity: observe a lower percentage of abnormalities than on the BALB/c background
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• Background Sensitivity: 100% penetrance of ventricular septal defect that is much larger than on the BALB/c background
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• Background Sensitivity: seen as early as E15.5 on the C57BL/6 background but not on the BALB/c background
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• Background Sensitivity: seen as early as E15.5 in both the left and right ventricle, on the C57BL/6 background but not on the BALB/c background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Mtc mutation
(0 available);
any
Hey2 mutation
(30 available)
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mortality/aging
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• exhibit decreased survival at 3 weeks of age due to cardiac defects
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cardiovascular system
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• Background Sensitivity: exhibit fewer mitral valve abnormalities than on the C57BL/6 background
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• Background Sensitivity: observe a greater percentage of tricuspid valve abnormalities such as tricuspid stenosis or tricuspid atresia than on the C57BL/6 background
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• Background Sensitivity: observe a greater percentage of tricuspid valve abnormalities such as tricuspid stenosis or tricuspid atresia than on the C57BL/6 background
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• about 1/3 show dysmoprhic cardiac septation, characterized by a thin walled septum in the same region where the small VSDs are seen in other mice
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• Background Sensitivity: about 1/4 exhibit a ventricular septal defect (VSD) that is much smaller than on the C57BL/6 background and is localized to the portion of the septum separating the right ventricle from the aortic outflow region of the left ventricle
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Mtc mutation
(0 available);
any
Hey2 mutation
(30 available)
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mortality/aging
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• variable timing of death, mainly within 1 week of birth
• Background Sensitivity: mortality is more severe on the 129X1/SvJ background than on the mixed background involving both 129X1/SvJ and C57BL/6
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cardiovascular system
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• no semilunar or atrioventricular valves abnormalities were observed
• normal aorta, pulmonary artery, and coronary arteries
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• most pups show severe pulmonary and liver congestion, suggestive of heart failure
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• absence of membranous septum
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• absence of membranous septum
• observed in 8 of 9 perinatal mice
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growth/size/body
liver/biliary system
respiratory system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Mtc mutation
(0 available);
any
Hey2 mutation
(30 available)
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Hey2tm1Mtc/Hey2tm1Mtc mice have ventricular septal defects
mortality/aging
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• some mice surviving to adulthood
• Background Sensitivity: incomplete penetrance, less severe than on the 129X1/SvJ background
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cardiovascular system
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• most pups show severe pulmonary and liver congestion, suggestive of heart failure
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• absence of membranous septum was observed in 4 of 6 perinatal mice
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• absence of membranous septum was observed in 4 of 6 perinatal mice
• however, normal semilunar and atrioventricular valves, aorta, pulmonary artery, and coronary artery morphology were seen
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• seen in mutants that survive to adulthood
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• systolic contractile dysfunction exhibited by surviving mice around 12 weeks of age
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• observed in 8 of 11 mixed background mice surviving to 40 weeks
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growth/size/body
muscle
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• systolic contractile dysfunction exhibited by surviving mice around 12 weeks of age
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• observed in 8 of 11 mixed background mice surviving to 40 weeks
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liver/biliary system
respiratory system
cellular
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• seen in mutants that survive to adulthood
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Analysis Tools