Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP)8.9Btla mutation
(1 available)
Tg(SOD1)51Yg mutation
(0 available)
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behavior/neurological
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• 9-month old mice show impaired memory retention in Morris water maze, exhibiting delayed escape latency compared to controls in all 6 trials
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• impairment observed at 10 months of age; mice show greater impairment than Tg(APP)8.9Btla mice
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• exploratory behavior is increased for both familiar and novel objects
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• at 9 months, a delay of learning process in Morris water maze is observed compared to controls; double mutants are significantly impaired relative to controls
• at 4.5 months of age, rate of learning platform position during first day of Morris water maze testing is impaired compared to controls or Tg(APP)8.9Btla/Tg(SOD1)69Yg double mutants
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• mice spend greater amounts of time in the closed arms of an elevated plus maze than Tg(SOD1)51Yg or Tg(APP)8.9Btla mice; time per entry into dark arms is increased relative to Tg(APP)8.9Btla mice and total entries into dark arms is greater than controls
• mice spend much more time in dark side of dark-light box than either single transgenic line or controls
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• transgenic mice display more spontaneous locomotor activity than controls
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nervous system
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• mic show a 2-fold increase of cortical APP proteins and a 2.5-2.8-fold increase in hippocampal APP levels compared to Tg(APP)8.9Btla mice
• no Abeta peptides are detected in 5 month old mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP)8.9Btla mutation
(1 available)
Tg(SOD1)69Yg mutation
(0 available)
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behavior/neurological
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• 9-month old mice show impaired memory retention in Morris water maze, exhibiting delayed escape latency compared to controls in all 6 trials
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• impairment observed at 10 months of age in Morris water maze
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• at 9 months, a delay of learning process in Morris water maze is observed compared to controls
• at 4.5 months of age, rate of learning platform position during first day of Morris water maze testing is impaired
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nervous system
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• mice display depotentiation to a smaller EPSP size
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1.1Ruvi mutation
(0 available);
any
Psen1 mutation
(46 available)
Tg(APP)8.9Btla mutation
(1 available)
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nervous system
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• keratan sulfate-positive-activated microglia
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• scarce small plaques in the hippocampus of young animals becoming more prominent with age
• small and scattered plaques at 6 months in the cerebral cortex
• prominent plaques with age in the neocortex and leptomeninges
• small and moderate sized plaques in the cerebral cortex
• parenchymal amyloid deposition in the cerebellum of older mice
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• in the cerebral cortex with amyloid deposition
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• neuritic dystrophy with clusters of swollen and abnormally distorted neuritic profiles
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immune system
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• keratan sulfate-positive-activated microglia
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hematopoietic system
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• keratan sulfate-positive-activated microglia
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP)8.9Btla mutation
(1 available)
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behavior/neurological
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• at 5.5 months of age, mice do not appear to recall platform position from the previous day of training and show a lower learning rate over subsequent trials
• impairment observed at 10 months of age
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• exploratory behavior is increased for both familiar and novel objects
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• at 9 months, a delay of learning process in Morris water maze is observed compared to controls
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• mice spend less time per entry into dark arms than controlsmice spend less time per entry into dark arms than controls
• mice exit dark side of dark-light box more often than controls
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• transgenic mice display more spontaneous locomotor activity than controls; activity is higher than in Tg(APP)8.9Btla or Tg(SOD1)51Yg mice
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vision/eye
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N |
• little or no perturbation of the retinas structure or cornea is observed
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• numerous bodies with circular profiles are present in all lens sections examined
• circles are present in lenses from mice >6 months of age; circles are 1-5 um in diameter
• lenses from 6 and 16 month-old mice contain swollen cortical fiber cells and lens plaques
• fiber cell nuclei are disorganized in the outer cortical region compared to wild-type
• lens degeneration is variable in severity and onset; in some cases, one lens is more severely affected than the other side
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• individual fiber cells are irregularly shaped and fiber cell arrays are misaligned
• lens fiber cell membranes are morphologically abnormal
• mice display age-related fiber cell degeneration and cortical plaque formation
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nervous system
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N |
• no Abeta peptides are detected in 5 month old mice
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Analysis Tools