Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation
(3 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(H2-K-BCL2)1Josd mutation
(0 available)
|
|
|
hematopoietic system
|
|
• GFP+ hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm2Iku mutation
(0 available);
any
Il7r mutation
(29 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
Tg(H2-K-BCL2)1Josd mutation
(0 available)
|
|
|
immune system
|
N |
• CD8+ numbers and CD8+/CD4+ ratio recovered from condition in mice lacking Tg(H2-K-BCL2)1Josd
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2tm1Mpin mutation
(1 available);
any
Bcl2 mutation
(41 available)
Tg(H2-K-BCL2)1Josd mutation
(0 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation
(0 available)
|
|
|
neoplasm
|
|
• exhibit rapid adenoma development
|
respiratory system
|
|
• exhibit rapid adenoma development
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
neoplasm
|
|
• 100% develop tumors by 1 month of age
|
respiratory system
|
|
• 100% develop tumors by 1 month of age
|
Allelic
Composition |
Tg(H2-K-BCL2)1Josd/0
|
|
Genetic
Background |
involves: C57BL/6 * C57BL/Ka * C3H |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
|
|
|
mortality/aging
|
|
• exhibit increased resistance to lethal challenges of x-ray irradiation, showing delayed death after irradiation compared to wild-type
|
hematopoietic system
|
|
• hematopoietic populations, such as mature B- and T-cells, natural killer cells, myeloid cells, erythroid cells, and stem cells, show increased resistance to the effects of irradiation
|
|
|
• increase in the number of circulating white blood cells
|
|
|
• increase in the number of hematopoietic stem cells
|
cellular
|
|
• exhibit increased resistance to lethal challenges of x-ray irradiation, showing an increase in the radioresistance of individual cells, and an increase in the size of certain critically important cell populations, such as the hematopoietic stem cells
|
immune system
|
|
• increase in the number of circulating white blood cells
|
|
|
• 2- to 5-fold increase in size of lymphoid organs
|
homeostasis/metabolism
endocrine/exocrine glands
growth/size/body
Analysis Tools