Analysis Tools
respiratory system
mortality/aging
|
• old mice tolerate anesthetics poorly
|
|
• decrease in median and maximal lifespans compared to wild-type controls
|
|
• mice exhibit some phenotypes associated with premature ageing
|
neoplasm
|
• mice exhibit a 20% tumor incidence by 18 months of age with most mice remaining tumor free by 18 months of age
|
homeostasis/metabolism
|
• old mice tolerate anesthetics poorly
|
|
• at 16 to 18 months of age
|
skeleton
lordokyphosis
(
J:73757
)
|
• by 18 to 20 months of age, mice exhibit lordokyphosis
|
osteoporosis
(
J:73757
)
|
• at 18 months of age
|
adipose tissue
|
• at 16 to 18 months of age
|
behavior/neurological
endocrine/exocrine glands
 |
• at 18 months of age
|
growth/size/body
weight loss
(
J:73757
)
|
• at 18 to 20 months of age
|
hematopoietic system
|
• at 18 months of age
|
immune system
|
• at 18 months of age
|
liver/biliary system
|
• at 18 months of age
|
muscle
|
• at 18 months of age
|
renal/urinary system
|
• at 18 months of age
|
reproductive system
|
|
• at 18 months of age
|
integument
|
• at 16 to 18 months of age
|
sparse hair
(
J:73757
)
|
• at 18 to 20 months of age
|
ruffled hair
(
J:73757
)
|
• at 18 to 20 months of age
|
|
• by 18 to 20 months of age, hair growth is observed is diminished compared to in wild-type mice
|
