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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Trp53A135V)L3Ber
transgene insertion L3, Alan Bernstein
MGI:2447408
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Trp53A135V)L3Ber/0 involves: C57BL/6 * CD-1 MGI:3814537


Genotype
MGI:3814537
tg1
Allelic
Composition
Tg(Trp53A135V)L3Ber/0
Genetic
Background
involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53A135V)L3Ber mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system

mortality/aging
• decrease in median and maximal lifespans compared to wild-type controls
• mice exhibit some phenotypes associated with premature ageing

neoplasm
• mice exhibit a 20% tumor incidence by 18 months of age with most mice remaining tumor free by 18 months of age

homeostasis/metabolism
• at 16 to 18 months of age

skeleton
• by 18 to 20 months of age, mice exhibit lordokyphosis
• at 18 months of age

adipose tissue
• at 16 to 18 months of age

behavior/neurological
• at 18 to 20 months of age

endocrine/exocrine glands
• at 18 months of age

growth/size/body
• at 18 to 20 months of age

hematopoietic system
• at 18 months of age

immune system
• at 18 months of age

liver/biliary system
• at 18 months of age

muscle
• at 18 months of age

renal/urinary system
• at 18 months of age

reproductive system
• at 18 months of age

integument
• at 16 to 18 months of age
• some in older mice
• at 18 to 20 months of age
• at 18 to 20 months of age
• by 18 to 20 months of age, hair growth is observed is diminished compared to in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory