Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(AGT)Sig mutation
(0 available);
any
Hprt1 mutation
(1273 available)
Tg(hAGT)2041Sig mutation
(1 available)
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cardiovascular system
 N |
• blood pressure and heart size are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(AGT)Sig mutation
(0 available);
any
Hprt1 mutation
(1273 available)
Tg(hAGT)2041Sig mutation
(1 available)
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cardiovascular system
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• females exhibit an increase in heart weight-to-body weight relative to controls
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growth/size/body
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• females exhibit an increase in heart weight-to-body weight relative to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(AGT)Sig mutation
(0 available);
any
Hprt1 mutation
(1273 available)
Tg(hAGT)2041Sig mutation
(1 available)
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cardiovascular system
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• males exhibit an increase in blood pressure of 9.7+/-0.9 mmHg compared to control littermates
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(hAGT)2041Sig mutation
(1 available)
Tg(hREN)9Sig mutation
(1 available)
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cardiovascular system
nervous system
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• mice exhibit a resetting of the baroreflex control of heart rate to a higher pressure without changing the gain or sensitivity of the reflex
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(hAGT)2041Sig mutation
(1 available)
Tg(hREN)9Sig mutation
(1 available)
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mortality/aging
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• following treatment with L-NAME and a high salt diet, all mice die
• mice on a high salt diet exhibit increased lethality associated with brain hemorrhages
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cardiovascular system
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• 2 mice treated with both L-NAME and a high salt diet exhibited a dissecting aortic aneurysm in addition to hemorrhagic stroke unlike similarly treated wild-type mice
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• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice
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• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice
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• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• following treatment with L-NAME and a high salt diet
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• following treatment with a high salt diet, mice exhibit an increase in systolic blood pressure not observed in similarly treated wild-type mice
• mice exhibit a higher systolic blood pressure than wild-type mice
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nervous system
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• following treatment with L-NAME and a high salt diet, 2 of 8 mice exhibit basal ganglia hemorrhages unlike wild-type mice
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• in all mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• in 4 of 8 mice but not observed in wild-type mice following treatment with L-NAME and a high salt diet
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• following treatment with L-NAME and a high salt diet
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homeostasis/metabolism
growth/size/body
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• following treatment with L-NAME and a high salt diet, the heart weight to body weight ratio is increased compared to in similarly treated wild-type mice
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Allelic
Composition |
Tg(hAGT)2041Sig/0
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Genetic
Background |
involves: C57BL/6 * SJL/J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(hAGT)2041Sig mutation
(1 available)
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cardiovascular system
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N |
• mice exhibit normal blood pressure
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• upon treatment with human renin
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Analysis Tools
