About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APP695)3Dbo
transgene insertion 3, David R Borchelt
MGI:2447334
Summary 16 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL MGI:5471581
cx2
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo MGI:3718026
cx3
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax MGI:4437308
cx4
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129 * C3H/HeJ * C57BL/6 MGI:5050413
cx5
Tlr2tm1Kir/Tlr2tm1Kir
Tg(APP695)3Dbo/?
Tg(PSEN1)5Dbo/?
involves: 129 * C3H/HeJ * C57BL/6 MGI:5428447
cx6
Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 MGI:3582996
cx7
Bace1tm1Pcw/Bace1tm1Pcw
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J MGI:3720944
cx8
Bace1tm1Pcw/Bace1+
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J MGI:3720945
cx9
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J MGI:3720946
cx10
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: C3H/HeJ * C57BL/6J MGI:3639713
cx11
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
involves: C3H/HeJ * C57BL/6J MGI:3663620
cx12
Tg(APP695)3Dbo/0
Tg(Eno2-PTGS2)32Pasi/0
Tg(PSEN1)5Dbo/0
involves: C3H/HeJ * C57BL/6J MGI:3720017
cx13
Tg(APP695)3Dbo/0
Tg(PSEN1)S8-4Dbo/0
involves: C57BL/6J * C3H/HeJ MGI:3663623
cx14
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Not Specified MGI:3837363
tg15
Tg(APP695)3Dbo/0 B6.C3-Tg(APP695)3Dbo MGI:3696575
tg16
Tg(APP695)3Dbo/0 involves: C3H/HeJ * C57BL/6J MGI:3663621


Genotype
MGI:5471581
cn1
Allelic
Composition
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1)5Dbo mutation (1 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age (J:192453)
• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy (J:192453)
• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months (J:192453)
• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance (J:192453)
• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age (J:192453)
• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy (J:192453)
• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months (J:192453)
• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance (J:192453)
• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy (J:192453)
• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy (J:192453)
• activation of astrocytes is enhanced compared to controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 1 year of age (J:192453)
• activation of astrocytes is enhanced compared to controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 1 year of age (J:192453)

homeostasis/metabolism
• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age (J:192453)
• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy (J:192453)
• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months (J:192453)
• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance (J:192453)
• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age (J:192453)
• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy (J:192453)
• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months (J:192453)
• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance (J:192453)
• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy (J:192453)
• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy (J:192453)




Genotype
MGI:3718026
cx2
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Genetic
Background
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1)5Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females (J:100956)
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females (J:100956)

behavior/neurological
• increased duration of immobility in Porsolt forced swim test (J:142183)
• increased duration of immobility in Porsolt forced swim test (J:142183)
• poor retention latency exhibited in light-dark step through box (J:142183)
• poor retention latency exhibited in light-dark step through box (J:142183)
• escape latencies across trial blocks in left-right discrimination learning are elevated and decrease little in comparison to decreased escape latencies exhibited in controls (J:142183)
• required higher trials to reach criterion and committed more errors in comparison to controls (J:142183)
• escape latencies across trial blocks in left-right discrimination learning are elevated and decrease little in comparison to decreased escape latencies exhibited in controls (J:142183)
• required higher trials to reach criterion and committed more errors in comparison to controls (J:142183)
• increased irritability in response to touch escape test as compared to control (J:142183)
• increased irritability in response to touch escape test as compared to control (J:142183)
• poor nest building ability in comparison to controls (J:142183)
• poor nest building ability in comparison to controls (J:142183)

integument
• increased irritability in response to touch escape test as compared to control (J:142183)
• increased irritability in response to touch escape test as compared to control (J:142183)

homeostasis/metabolism
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females (J:100956)
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females (J:100956)




Genotype
MGI:4437308
cx3
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

homeostasis/metabolism

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:157228




Genotype
MGI:5050413
cx4
Allelic
Composition
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129 * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1tm1Tew mutation (0 available); any Sorl1 mutation (7 available)
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta (J:142501)
• some of the largest differences in amyloid measures are detected in the cerebellum (J:142501)
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta (J:142501)
• some of the largest differences in amyloid measures are detected in the cerebellum (J:142501)

homeostasis/metabolism
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta (J:142501)
• some of the largest differences in amyloid measures are detected in the cerebellum (J:142501)
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta (J:142501)
• some of the largest differences in amyloid measures are detected in the cerebellum (J:142501)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:142501




Genotype
MGI:5428447
cx5
Allelic
Composition
Tlr2tm1Kir/Tlr2tm1Kir
Tg(APP695)3Dbo/?
Tg(PSEN1)5Dbo/?
Genetic
Background
involves: 129 * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1)5Dbo mutation (1 available)
Tlr2tm1Kir mutation (2 available); any Tlr2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• retention is reduced in passive avoidance tests involving electric shock training to prevent movement from a lighted area to a dark chamber (J:136387)
• retention is reduced in passive avoidance tests involving electric shock training to prevent movement from a lighted area to a dark chamber (J:136387)
• retention of spatial memory in T-water maze tests declines as early as 3 months after acquisition, faster than for transgenics alone (J:136387)
• acquisition of spatial memory in T-water maze tests is normal (J:136387)
• retention of spatial memory in T-water maze tests declines as early as 3 months after acquisition, faster than for transgenics alone (J:136387)
• acquisition of spatial memory in T-water maze tests is normal (J:136387)

nervous system
• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months (J:136387)
• higher brain levels of Abeta1-42 (J:136387)
• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months (J:136387)
• higher brain levels of Abeta1-42 (J:136387)

homeostasis/metabolism
• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months (J:136387)
• higher brain levels of Abeta1-42 (J:136387)
• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months (J:136387)
• higher brain levels of Abeta1-42 (J:136387)




Genotype
MGI:3582996
cx6
Allelic
Composition
Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klc1tm1Gsn mutation (1 available); any Klc1 mutation (32 available)
Tg(APP695)3Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• levels of amyloid beta are consistently elevated relative to controls (J:96346)
• levels of amyloid beta are consistently elevated relative to controls (J:96346)
• increased axonal swelling independent of amyloid deposition (J:96346)
• increased axonal swelling independent of amyloid deposition (J:96346)

homeostasis/metabolism
• levels of amyloid beta are consistently elevated relative to controls (J:96346)
• levels of amyloid beta are consistently elevated relative to controls (J:96346)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:96346




Genotype
MGI:3720944
cx7
Allelic
Composition
Bace1tm1Pcw/Bace1tm1Pcw
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Pcw mutation (1 available); any Bace1 mutation (4 available)
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice perform as well as control mice in platform and probe trials in Morris water maze tasks (J:123534)
• mice perform as well as control mice in platform and probe trials in Morris water maze tasks (J:123534)
• in open field test, mice are similar to Bace1tm1Pcw homozygotes, and spend more time in open area at center of field than at periphery (J:123534)
• in open field test, mice are similar to Bace1tm1Pcw homozygotes, and spend more time in open area at center of field than at periphery (J:123534)
• swim speed is lower than other genotypes and nontransgenic mice in hidden and visible platform trials (J:123534)
• swim speed is lower than other genotypes and nontransgenic mice in hidden and visible platform trials (J:123534)

nervous system
N
• in 12- or 20-month old mice, no amyloid beta (Abeta) aggregation is detected in brains; no amyloid deposits are found (J:123534)
• in 12- or 20-month old mice, no amyloid beta (Abeta) aggregation is detected in brains; no amyloid deposits are found (J:123534)




Genotype
MGI:3720945
cx8
Allelic
Composition
Bace1tm1Pcw/Bace1+
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Pcw mutation (1 available); any Bace1 mutation (4 available)
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice are significantly impaired in Morris water maze tasks (J:123534)
• mice are significantly impaired in Morris water maze tasks (J:123534)

nervous system
• high level of amyloid beta aggregates are found in brain at 12 months of age (J:123534)
• high level of amyloid beta aggregates are found in brain at 12 months of age (J:123534)

homeostasis/metabolism
• in 12-month old brains, there is a 27% reduction in amyloid beta aggregates compared to transgenic mice that are wild-type for Bace1; there are no significant differences at 20 months (J:123534)
• in 12-month old brains, there is 37% reduction in percentage of brain volume occupied by amyloid beta deposits, but no difference at 20 months (J:123534)
• in 12-month old brains, there is a 27% reduction in amyloid beta aggregates compared to transgenic mice that are wild-type for Bace1; there are no significant differences at 20 months (J:123534)
• in 12-month old brains, there is 37% reduction in percentage of brain volume occupied by amyloid beta deposits, but no difference at 20 months (J:123534)
• high level of amyloid beta aggregates are found in brain at 12 months of age (J:123534)
• high level of amyloid beta aggregates are found in brain at 12 months of age (J:123534)




Genotype
MGI:3720946
cx9
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
(J:123534)
(J:123534)
• mice travel shorter distance in open-field and show less activity or excursions into central area; mice remain near periphery of apparatus rather than entering open center of field (J:123534)
• mice travel shorter distance in open-field and show less activity or excursions into central area; mice remain near periphery of apparatus rather than entering open center of field (J:123534)
• 16-18 month-old mice swim farther to find platform and spend less time in platform vicinity than controls (J:123534)
• 16-18 month-old mice swim farther to find platform and spend less time in platform vicinity than controls (J:123534)

nervous system
• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus (J:123534)
• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus (J:123534)

homeostasis/metabolism
• mice display amyloid beta aggregates at 12 and 20 months (J:123534)
• mice display amyloid beta aggregates at 12 and 20 months (J:123534)
• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus (J:123534)
• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus (J:123534)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:123534
Alzheimer Disease; AD 104300 J:123534




Genotype
MGI:3639713
cx10
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)
• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)
• 150% increase in amyloid beta peptide 42 (J:87691)
• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)
• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)
• 150% increase in amyloid beta peptide 42 (J:87691)
• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)
• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)

homeostasis/metabolism
• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)
• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)
• 150% increase in amyloid beta peptide 42 (J:87691)
• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)
• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)
• 150% increase in amyloid beta peptide 42 (J:87691)
• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)
• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)




Genotype
MGI:3663620
cx11
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1)5Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no differences in neuron number in cingulate cortex relative to wild-type (J:100961)
• no differences in neuron number in cingulate cortex relative to wild-type (J:100961)
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)
• associated with dystropic neuritis in cortex and hippocampus (J:43788)
• associated with dystropic neuritis in cortex and hippocampus (J:43788)
• dystrophic neuritis associated with reactive gliosis in cortex and hippocampus (J:43788)
• dystrophic neuritis associated with reactive gliosis in cortex and hippocampus (J:43788)
• neurons in cingulate cortex display 3-fold elevation in phosphorylated tumor suppressor protein (pRb) and activated caspase-3 relative to wild-type neurons (J:100961)
• neurons in cingulate cortex display 3-fold elevation in phosphorylated tumor suppressor protein (pRb) and activated caspase-3 relative to wild-type neurons (J:100961)

homeostasis/metabolism
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)




Genotype
MGI:3720017
cx12
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(Eno2-PTGS2)32Pasi/0
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(Eno2-PTGS2)32Pasi mutation (0 available)
Tg(PSEN1)5Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no differences in neuron number in cingulate cortex relative to wild-type (J:100961)
• no differences in neuron number in cingulate cortex relative to wild-type (J:100961)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)

homeostasis/metabolism
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)




Genotype
MGI:3663623
cx13
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1)S8-4Dbo/0
Genetic
Background
involves: C57BL/6J * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1)S8-4Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 9 or 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0 (J:43788)
• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 9 or 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0 (J:43788)




Genotype
MGI:3837363
cx14
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics (J:139070)
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (J:139070)
• microglia density, but not cell body size, is increased in transgenics (J:139070)
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics (J:139070)
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (J:139070)
• microglia density, but not cell body size, is increased in transgenics (J:139070)
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (J:139070)
• plaques have radial branches with a central core (J:139070)
• plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months (J:139070)
• plaques appear earlier in females than in males and increase in number over time (J:139070)
• 100% of females and 75% of males have plaques in retina by 15-16 months (J:139070)
• 100% of females and 75% of males have plaques in retina by 15-16 months (J:139070)
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (J:139070)
• plaques have radial branches with a central core (J:139070)
• plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months (J:139070)
• plaques appear earlier in females than in males and increase in number over time (J:139070)
• distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining (J:139070)
• distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining (J:139070)

vision/eye
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (J:139070)
• most plaques (34.7% and 41% respectively) are found in the inner and outer plexiform layers (J:139070)
• thickness of the retinal nuclear layers is similar to control, suggesting that there is no obvious neuronal cell loss (J:139070)
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (J:139070)
• most plaques (34.7% and 41% respectively) are found in the inner and outer plexiform layers (J:139070)
• thickness of the retinal nuclear layers is similar to control, suggesting that there is no obvious neuronal cell loss (J:139070)
• distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining (J:139070)
• distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining (J:139070)
• thioflavine-S positive plaques are first observed in females in the IPL at 12 months (J:139070)
• plaques are first observed in males at 13 months (J:139070)
• plaques are embedded within IPL cholinergic bands (J:139070)
• thioflavine-S positive plaques are first observed in females in the IPL at 12 months (J:139070)
• plaques are first observed in males at 13 months (J:139070)
• plaques are embedded within IPL cholinergic bands (J:139070)
• thioflavine-S positive plaques are first observed in females in the OPL at 12 months (J:139070)
• plaques are first observed in males at 13 months (J:139070)
• thioflavine-S positive plaques are first observed in females in the OPL at 12 months (J:139070)
• plaques are first observed in males at 13 months (J:139070)
• amplitudes of a and b waves are decreased in 12-16 month old mice when tested at lower light intensity, but not a higher intensity (J:139070)
• latency and implicit time as determined by ERG measurement are similar to control (J:139070)
• amplitudes of a and b waves are decreased in 12-16 month old mice when tested at lower light intensity, but not a higher intensity (J:139070)
• latency and implicit time as determined by ERG measurement are similar to control (J:139070)

immune system
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics (J:139070)
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (J:139070)
• microglia density, but not cell body size, is increased in transgenics (J:139070)
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics (J:139070)
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (J:139070)
• microglia density, but not cell body size, is increased in transgenics (J:139070)

hematopoietic system
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics (J:139070)
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (J:139070)
• microglia density, but not cell body size, is increased in transgenics (J:139070)
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics (J:139070)
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control (J:139070)
• microglia density, but not cell body size, is increased in transgenics (J:139070)

homeostasis/metabolism
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (J:139070)
• plaques have radial branches with a central core (J:139070)
• plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months (J:139070)
• plaques appear earlier in females than in males and increase in number over time (J:139070)
• 100% of females and 75% of males have plaques in retina by 15-16 months (J:139070)
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age (J:139070)
• plaques have radial branches with a central core (J:139070)
• plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months (J:139070)
• plaques appear earlier in females than in males and increase in number over time (J:139070)
• 100% of females and 75% of males have plaques in retina by 15-16 months (J:139070)




Genotype
MGI:3696575
tg15
Allelic
Composition
Tg(APP695)3Dbo/0
Genetic
Background
B6.C3-Tg(APP695)3Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations (J:109847)
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice (J:109847)
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals (J:109847)
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations (J:109847)
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice (J:109847)
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals (J:109847)

behavior/neurological
• at 24 months, males display a mild deterioration of sensorimotor abilities (J:109847)
• at 24 months, males display a mild deterioration of sensorimotor abilities (J:109847)
• mice backcrossed 10 generations have higher reactivity to acoustic stimuli compared to wild-type (J:109847)
• mice backcrossed 10 generations have higher reactivity to acoustic stimuli compared to wild-type (J:109847)
• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task (J:109847)
• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task (J:109847)

homeostasis/metabolism
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations (J:109847)
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice (J:109847)
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals (J:109847)
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations (J:109847)
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice (J:109847)
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals (J:109847)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 4 606889 J:109847
Alzheimer Disease; AD 104300 J:109847




Genotype
MGI:3663621
tg16
Allelic
Composition
Tg(APP695)3Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0 (J:43788)
• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0 (J:43788)
• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)
• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)
• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)
• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

homeostasis/metabolism
• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)
• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)
• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)
• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:87691





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory