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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APP695)3Dbo
transgene insertion 3, David R Borchelt
MGI:2447334
Summary 16 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL MGI:5471581
cx2
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo MGI:3718026
cx3
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax MGI:4437308
cx4
Tlr2tm1Kir/Tlr2tm1Kir
Tg(APP695)3Dbo/?
Tg(PSEN1)5Dbo/?
involves: 129 * C3H/HeJ * C57BL/6 MGI:5428447
cx5
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129 * C3H/HeJ * C57BL/6 MGI:5050413
cx6
Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 MGI:3582996
cx7
Bace1tm1Pcw/Bace1tm1Pcw
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J MGI:3720944
cx8
Bace1tm1Pcw/Bace1+
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J MGI:3720945
cx9
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J MGI:3720946
cx10
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
involves: C3H/HeJ * C57BL/6J MGI:3663620
cx11
Tg(APP695)3Dbo/0
Tg(Eno2-PTGS2)32Pasi/0
Tg(PSEN1)5Dbo/0
involves: C3H/HeJ * C57BL/6J MGI:3720017
cx12
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
involves: C3H/HeJ * C57BL/6J MGI:3639713
cx13
Tg(APP695)3Dbo/0
Tg(PSEN1)S8-4Dbo/0
involves: C57BL/6J * C3H/HeJ MGI:3663623
cx14
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Not Specified MGI:3837363
tg15
Tg(APP695)3Dbo/0 B6.C3-Tg(APP695)3Dbo MGI:3696575
tg16
Tg(APP695)3Dbo/0 involves: C3H/HeJ * C57BL/6J MGI:3663621


Genotype
MGI:5471581
cn1
Allelic
Composition
Lrp1tm2Her/Lrp1tm2Her
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (91 available)
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1)5Dbo mutation (0 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age
• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy
• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months
• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance
• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy
• activation of astrocytes is enhanced compared to controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 1 year of age

homeostasis/metabolism
• amyloid beta deposition in the brains is higher than in controls with only Tg(PSEN1)5Dbo and Tg(APP69ff5)3Dbo at 13-14 months of age
• amyloid beta deposition is seen in the cortical parenchyma and in cortical vessels as cerebral amyloid angiopathy
• concentrations of insoluble amyloid beta40 and amyloid beta42 is higher than in controls at 13-14 months of age but not at 3 months
• despite the increase in amyloid beta deposition, APP processing and levels of amyloid beta degrading enzymes are normal, indicating that the increase is due to a disturbance of lysosomal-mediated amyloid beta clearance
• amyloid beta deposition is seen in cortical vessels as cerebral amyloid angiopathy




Genotype
MGI:3718026
cx2
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Genetic
Background
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1)5Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1)5Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females

behavior/neurological
• poor retention latency exhibited in light-dark step through box
• escape latencies across trial blocks in left-right discrimination learning are elevated and decrease little in comparison to decreased escape latencies exhibited in controls
• required higher trials to reach criterion and committed more errors in comparison to controls
• increased duration of immobility in Porsolt forced swim test
• increased irritability in response to touch escape test as compared to control
• poor nest building ability in comparison to controls

integument
• increased irritability in response to touch escape test as compared to control

homeostasis/metabolism
• at 12 and 17 months of age, females have significantly more plaques in the hippocampus compared to males; plaque load increases dramatically with age in mice, particularly in females




Genotype
MGI:4437308
cx3
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
B6.Cg-Tg(APP695)3Dbo Tg(PSEN1dE9)S9Dbo/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

homeostasis/metabolism

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:157228




Genotype
MGI:5428447
cx4
Allelic
Composition
Tlr2tm1Kir/Tlr2tm1Kir
Tg(APP695)3Dbo/?
Tg(PSEN1)5Dbo/?
Genetic
Background
involves: 129 * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1)5Dbo mutation (0 available)
Tlr2tm1Kir mutation (2 available); any Tlr2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• retention is reduced in passive avoidance tests involving electric shock training to prevent movement from a lighted area to a dark chamber
• retention of spatial memory in T-water maze tests declines as early as 3 months after acquisition, faster than for transgenics alone
• acquisition of spatial memory in T-water maze tests is normal

nervous system
• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months
• higher brain levels of Abeta1-42

homeostasis/metabolism
• lower rate of plaque deposition at 3 and 6 months of age but equivalent to controls at 9 months
• higher brain levels of Abeta1-42




Genotype
MGI:5050413
cx5
Allelic
Composition
Sorl1tm1Tew/Sorl1tm1Tew
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129 * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sorl1tm1Tew mutation (0 available); any Sorl1 mutation (44 available)
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta
• some of the largest differences in amyloid measures are detected in the cerebellum

homeostasis/metabolism
• amyloid beta levels and amyloid plaque burden are increased at 4.5 and 6 months of age, but not at 12 months of age, compared to transgenic mice wild-type for Sorl1 suggesting an acceleration in accumulation of amyloid beta
• some of the largest differences in amyloid measures are detected in the cerebellum

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:142501




Genotype
MGI:3582996
cx6
Allelic
Composition
Klc1tm1Gsn/Klc1+
Tg(APP695)3Dbo/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klc1tm1Gsn mutation (1 available); any Klc1 mutation (40 available)
Tg(APP695)3Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• levels of amyloid beta are consistently elevated relative to controls
• increased axonal swelling independent of amyloid deposition

homeostasis/metabolism
• levels of amyloid beta are consistently elevated relative to controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:96346




Genotype
MGI:3720944
cx7
Allelic
Composition
Bace1tm1Pcw/Bace1tm1Pcw
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Pcw mutation (1 available); any Bace1 mutation (7 available)
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice perform as well as control mice in platform and probe trials in Morris water maze tasks
• in open field test, mice are similar to Bace1tm1Pcw homozygotes, and spend more time in open area at center of field than at periphery
• swim speed is lower than other genotypes and nontransgenic mice in hidden and visible platform trials

nervous system
N
• in 12- or 20-month old mice, no amyloid beta (Abeta) aggregation is detected in brains; no amyloid deposits are found




Genotype
MGI:3720945
cx8
Allelic
Composition
Bace1tm1Pcw/Bace1+
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Pcw mutation (1 available); any Bace1 mutation (7 available)
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1dE9)S9Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice are significantly impaired in Morris water maze tasks

nervous system
• high level of amyloid beta aggregates are found in brain at 12 months of age

homeostasis/metabolism
• in 12-month old brains, there is a 27% reduction in amyloid beta aggregates compared to transgenic mice that are wild-type for Bace1; there are no significant differences at 20 months
• in 12-month old brains, there is 37% reduction in percentage of brain volume occupied by amyloid beta deposits, but no difference at 20 months
• high level of amyloid beta aggregates are found in brain at 12 months of age




Genotype
MGI:3720946
cx9
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice travel shorter distance in open-field and show less activity or excursions into central area; mice remain near periphery of apparatus rather than entering open center of field
• 16-18 month-old mice swim farther to find platform and spend less time in platform vicinity than controls

nervous system
• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus

homeostasis/metabolism
• mice display amyloid beta aggregates at 12 and 20 months
• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:123534
Alzheimer Disease; AD 104300 J:123534




Genotype
MGI:3663620
cx10
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (0 available)
Tg(PSEN1)5Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no differences in neuron number in cingulate cortex relative to wild-type
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)
• associated with dystropic neuritis in cortex and hippocampus
• dystrophic neuritis associated with reactive gliosis in cortex and hippocampus
• neurons in cingulate cortex display 3-fold elevation in phosphorylated tumor suppressor protein (pRb) and activated caspase-3 relative to wild-type neurons

homeostasis/metabolism
• amyloid beta deposits found in cortex and hippocampus tissue from 9 and 12 month old mice and increase in number between 10 ans 12 months of age (J:43788)
• amyloid beta peptides AB1-40 and AB1-42 are codeposited (J:43788)
• ratio of amyloid beta peptide 40:42 is 1.75:1 (J:87691)
• exhibits a 50% increase in amyloid beta peptide 42 (J:87691)
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old double transgenic mice; deposits are most evident in gray matter of cingulate and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation (J:100961)




Genotype
MGI:3720017
cx11
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(Eno2-PTGS2)32Pasi/0
Tg(PSEN1)5Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APP695)3Dbo mutation (0 available)
Tg(Eno2-PTGS2)32Pasi mutation (0 available)
Tg(PSEN1)5Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no differences in neuron number in cingulate cortex relative to wild-type
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation

homeostasis/metabolism
• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation




Genotype
MGI:3639713
cx12
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)
• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)
• 150% increase in amyloid beta peptide 42 (J:87691)
• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)

homeostasis/metabolism
• develops diffuse, compact, birefringent congophilic plaques in cortex and hippocampus (J:87691)
• ratio of amyloid beta peptide 40:42 is 0.75:1 (J:87691)
• 150% increase in amyloid beta peptide 42 (J:87691)
• at 7 months of age, mice exhibit amyloid plaques in the hippocampus and cortex (J:104236)




Genotype
MGI:3663623
cx13
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1)S8-4Dbo/0
Genetic
Background
involves: C57BL/6J * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 9 or 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0




Genotype
MGI:3837363
cx14
Allelic
Composition
Tg(APP695)3Dbo/0
Tg(PSEN1dE9)S9Dbo/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control
• microglia density, but not cell body size, is increased in transgenics
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age
• plaques have radial branches with a central core
• plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months
• plaques appear earlier in females than in males and increase in number over time
• 100% of females and 75% of males have plaques in retina by 15-16 months
• distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining

vision/eye
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age
• most plaques (34.7% and 41% respectively) are found in the inner and outer plexiform layers
• thickness of the retinal nuclear layers is similar to control, suggesting that there is no obvious neuronal cell loss
• distribution of amacrine cell processes is disrupted as determined by syntaxin 1 staining
• thioflavine-S positive plaques are first observed in females in the IPL at 12 months
• plaques are first observed in males at 13 months
• plaques are embedded within IPL cholinergic bands
• thioflavine-S positive plaques are first observed in females in the OPL at 12 months
• plaques are first observed in males at 13 months
• amplitudes of a and b waves are decreased in 12-16 month old mice when tested at lower light intensity, but not a higher intensity
• latency and implicit time as determined by ERG measurement are similar to control

immune system
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control
• microglia density, but not cell body size, is increased in transgenics

hematopoietic system
• increase in microglial cell activity in retina is observed in 12-15 month old transgenics
• microglia processes in the retina are thicker and display a dendritic-like appearance as compared to control
• microglia density, but not cell body size, is increased in transgenics

homeostasis/metabolism
• thioflavine-S positive plaques are observed in the retina beginning at 12 months of age
• plaques have radial branches with a central core
• plaque size ranges from 5-20 um, larger plaques are observed at 15-16 months
• plaques appear earlier in females than in males and increase in number over time
• 100% of females and 75% of males have plaques in retina by 15-16 months




Genotype
MGI:3696575
tg15
Allelic
Composition
Tg(APP695)3Dbo/0
Genetic
Background
B6.C3-Tg(APP695)3Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

behavior/neurological
• at 24 months, males display a mild deterioration of sensorimotor abilities
• mice backcrossed 10 generations have higher reactivity to acoustic stimuli compared to wild-type
• in radial maze testing, male mutants backcrossed 5-7 generations show high motor reactivity compared to females or control animals, and entered the closest arm of the maze which prevented them from learning the task

homeostasis/metabolism
• in mice 26 months old, moderate levels of amyloid deposits in brains are observed in mice backcrossed 5-7 generations
• mice 12-13 months old that have been backcrossed 10 generations have slightly higher accumulations than Tg(APP695)3Dbo mice
• old (<24 months) animals backcrossed either 5-7 or 10 times to B6 have significantly higher levels of amyloid Abeta in their brains than adult (~9.6 months) or middle aged (13-15 months) animals

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 4 606889 J:109847
Alzheimer Disease; AD 104300 J:109847




Genotype
MGI:3663621
tg16
Allelic
Composition
Tg(APP695)3Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no immunoreactive amyloid beta deposits found in cortex or hippocampus from 12 month old mice as compared to double transgenic mice: Tg(APP695)3Dbo/0, Tg(PSEN1)5Dbo/0
• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)
• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

homeostasis/metabolism
• amyloid beta deposits observed in cortex and hippocampus of 18 and 20 month old mice (J:43788)
• ratio of amyloid beta peptide 40:42 is 3:1 (J:87691)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:87691





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory