All Phenotypes Snai2<tm2Grid> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Snai2^tm2Grid
targeted mutation 2, Tom Gridley
MGI:2447176

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snai2^tm2Grid/Snai2^tm2Grid	involves: 129S1/Sv	MGI:2652604
hm2	Snai2^tm2Grid/Snai2^tm2Grid	involves: 129S1/Sv * C57BL/6	MGI:3715217
cn3	Meox2^tm1(cre)Sor/Meox2⁺ Snai1^tm1Grid/Snai1^tm2Grid Snai2^tm2Grid/Snai2^tm2Grid	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:3715232
cn4	Snai1^tm1Grid/Snai1^tm2Grid Snai2^tm2Grid/Snai2^tm2Grid H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3715216
cx5	Kit^W-v/Kit⁺ Snai2^tm2Grid/Snai2^tm2Grid	involves: 129S1/Sv * C57BL	MGI:2652596
cx6	Kit^W-v/Kit⁺ Snai2^tm2Grid/Snai2⁺	involves: 129S1/Sv * C57BL	MGI:2652598
cx7	Snai1^tm1Grid/Snai1⁺ Snai2^tm2Grid/Snai2^tm2Grid	involves: 129S1/Sv * C57BL/6	MGI:3715218
cx8	Snai2^tm2Grid/Snai2^tm2Grid Snai3^tm1.2Jhws/Snai3^tm1.2Jhws	involves: 129/Sv * 129S1/Sv * C57BL/6	MGI:5620202
cx9	Snai2^tm2Grid/Snai2⁺ Snai3^tm1.2Jhws/Snai3^tm1.2Jhws	involves: 129/Sv * 129S1/Sv * C57BL/6	MGI:5620264
cx10	Snai2^tm2Grid/Snai2^tm2Grid Snai3^tm1.2Jhws/Snai3⁺	involves: 129/Sv * 129S1/Sv * C57BL/6	MGI:5620265

Allelic Composition	Snai2^tm2Grid/Snai2^tm2Grid
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2^tm2Grid mutation (1 available); any Snai2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

diluted coat color ( J:78323 )

head blaze ( J:78323 )

• white forehead blaze occasionally noted

variable body spotting ( J:78323 , J:80529 )

• occasional white spotting of coat (J:78323)

• mutants exhibit areas of hypopigmentation on the midforehead and extremity depigmentation (J:80529)

abnormal skin pigmentation ( J:78323 )

• various degrees of dermal depigmentation; tails and feet are often depigmented

decreased forehead pigmentation ( J:80529 )

• areas of hypopigmentation on the midforehead

craniofacial

decreased forehead pigmentation ( J:80529 )

• areas of hypopigmentation on the midforehead

behavior/neurological

hyperactivity ( J:78323 , J:80529 )

• genetic background effects were noted, but not specified (J:78323)

circling ( J:78323 , J:80529 )

• genetic background effects were noted, but not specified (J:78323)

endocrine/exocrine glands

small thymus ( J:78323 )

• apoptotic cells were noted in the cortical level

small seminiferous tubules ( J:78323 )

• despite the reduced size of the tubules, spermatogenesis appeared normal

small testis ( J:78323 )

• testes were reduced by 40% compared to controls

growth/size/body

decreased forehead pigmentation ( J:80529 )

• areas of hypopigmentation on the midforehead

decreased body size ( J:48521 )

• at time of weaning animals weighed 70% that of wild-type and heterozygous littermates

postnatal growth retardation ( J:48521 )

• animals showed moderate growth retardation during the first 3 weeks of life

• after weaning, growth rate matches that of wild-type but animals never attain wild-type body size

hematopoietic system

small thymus ( J:78323 )

• apoptotic cells were noted in the cortical level

abnormal T cell differentiation ( J:78323 )

• a partial block in T cell differentiation in the thymus resulted in fewer mature CD4+/CD8+ cells

macrocytic anemia ( J:78323 )

decreased hematocrit ( J:78323 )

decreased hemoglobin content ( J:78323 )

increased mean corpuscular volume ( J:78323 )

thrombocytopenia ( J:78323 )

decreased leukocyte cell number ( J:78323 )

immune system

small thymus ( J:78323 )

• apoptotic cells were noted in the cortical level

abnormal T cell differentiation ( J:78323 )

• a partial block in T cell differentiation in the thymus resulted in fewer mature CD4+/CD8+ cells

decreased leukocyte cell number ( J:78323 )

blepharitis ( J:48521 )

• variable degrees of inflammation; almost all homozygotes develop swollen eyelids

conjunctivitis ( J:48521 )

• variable degrees of neutrophilic infiltration

reproductive system

small seminiferous tubules ( J:78323 )

• despite the reduced size of the tubules, spermatogenesis appeared normal

small testis ( J:78323 )

• testes were reduced by 40% compared to controls

decreased litter size ( J:78323 )

• small litters from homozygous males were produced; on average the litter size was 3-6 pups vs. 10-12 in controls

male infertility ( J:78323 )

• incomplete penetrance; 15% of males fail to induce pregnancy despite producing plugs in females

reduced male fertility ( J:78323 )

• small litters from homozygous males were produced; on average the litter size was 3-6 pups vs. 10-12 in controls

vision/eye

blepharitis ( J:48521 )

• variable degrees of inflammation; almost all homozygotes develop swollen eyelids

conjunctivitis ( J:48521 )

• variable degrees of neutrophilic infiltration

abnormal conjunctiva morphology ( J:48521 )

• histological analysis revealed a number of conjunctival abnormalities

integument

diluted coat color ( J:78323 )

head blaze ( J:78323 )

• white forehead blaze occasionally noted

variable body spotting ( J:78323 , J:80529 )

• occasional white spotting of coat (J:78323)

• mutants exhibit areas of hypopigmentation on the midforehead and extremity depigmentation (J:80529)

abnormal skin pigmentation ( J:78323 )

• various degrees of dermal depigmentation; tails and feet are often depigmented

decreased forehead pigmentation ( J:80529 )

• areas of hypopigmentation on the midforehead

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Waardenburg syndrome		DOID:9258	OMIM:PS193500	J:80529

Allelic Composition	Snai2^tm2Grid/Snai2^tm2Grid
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2^tm2Grid mutation (1 available); any Snai2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:121243 )

• homozygotes with cleft palate die shortly after birth

craniofacial

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• at E15.0 palatal shelves elevate normally and come together at midline, but fail to form medial epithelial seam and fuse

cleft secondary palate ( J:121243 )

• ~50% of homozygotes display cleft secondary palate

digestive/alimentary system

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• at E15.0 palatal shelves elevate normally and come together at midline, but fail to form medial epithelial seam and fuse

cleft secondary palate ( J:121243 )

• ~50% of homozygotes display cleft secondary palate

growth/size/body

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• at E15.0 palatal shelves elevate normally and come together at midline, but fail to form medial epithelial seam and fuse

cleft secondary palate ( J:121243 )

• ~50% of homozygotes display cleft secondary palate

Allelic Composition	Meox2^tm1(cre)Sor/Meox2⁺ Snai1^tm1Grid/Snai1^tm2Grid Snai2^tm2Grid/Snai2^tm2Grid
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Snai1^tm1Grid mutation (0 available); any Snai1 mutation (9 available)
Snai1^tm2Grid mutation (1 available); any Snai1 mutation (9 available)
Snai2^tm2Grid mutation (1 available); any Snai2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryonic growth retardation ( J:111702 )

open neural tube ( J:111702 )

• double mutants display an open neural tube at E9.5

growth/size/body

embryonic growth retardation ( J:111702 )

nervous system

nervous system phenotype ( J:111702 )

N	• in E8.5 cranial fold explants cultured for 48 hours, neural crest cell delamination and migration are observed, similar to control explants

open neural tube ( J:111702 )

• double mutants display an open neural tube at E9.5

Allelic Composition	Snai1^tm1Grid/Snai1^tm2Grid Snai2^tm2Grid/Snai2^tm2Grid H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Snai1^tm1Grid mutation (0 available); any Snai1 mutation (9 available)
Snai1^tm2Grid mutation (1 available); any Snai1 mutation (9 available)
Snai2^tm2Grid mutation (1 available); any Snai2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:121243 )

• resulting from cleft palate

craniofacial

abnormal Meckel's cartilage morphology ( J:121243 )

• the rostral portion of the Meckels cartilage is missing in neonates

frontal bone foramen ( J:121243 )

• enlarged frontal foramen in neonates

short parietal bone ( J:121243 )

• nenates have shortened parietal bones

short mandible ( J:121243 )

• mandible is shorter than in wild-type

domed cranium ( J:121243 )

• in neonates

abnormal palatal shelf morphology ( J:121243 )

• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5

cleft palate ( J:121243 )

• neonates show cleft palate

failure of palatal shelf elevation ( J:121243 )

• palatal shelves remain in a vertical growth orientation and fail to elevate

skeleton

abnormal Meckel's cartilage morphology ( J:121243 )

• the rostral portion of the Meckels cartilage is missing in neonates

frontal bone foramen ( J:121243 )

• enlarged frontal foramen in neonates

short parietal bone ( J:121243 )

• nenates have shortened parietal bones

short mandible ( J:121243 )

• mandible is shorter than in wild-type

domed cranium ( J:121243 )

• in neonates

digestive/alimentary system

abnormal palatal shelf morphology ( J:121243 )

• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5

cleft palate ( J:121243 )

• neonates show cleft palate

failure of palatal shelf elevation ( J:121243 )

• palatal shelves remain in a vertical growth orientation and fail to elevate

growth/size/body

abnormal palatal shelf morphology ( J:121243 )

• anterior palatal shelves of some double null mutants show subtle size and shape differences relative to wild-type palates at E13.5 and 14.5

cleft palate ( J:121243 )

• neonates show cleft palate

failure of palatal shelf elevation ( J:121243 )

• palatal shelves remain in a vertical growth orientation and fail to elevate

Allelic Composition	Kit^W-v/Kit⁺ Snai2^tm2Grid/Snai2^tm2Grid
Genetic Background	involves: 129S1/Sv * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^W-v mutation (10 available); any Kit mutation (179 available)
Snai2^tm2Grid mutation (1 available); any Snai2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

variable body spotting ( J:80529 )

• extensive white spotting of coat was noted from birth

integument

variable body spotting ( J:80529 )

• extensive white spotting of coat was noted from birth

Allelic Composition	Kit^W-v/Kit⁺ Snai2^tm2Grid/Snai2⁺
Genetic Background	involves: 129S1/Sv * C57BL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

variable body spotting ( J:80529 )

• extensive white spotting of coat was noted from birth

integument

variable body spotting ( J:80529 )

• extensive white spotting of coat was noted from birth

Allelic Composition	Snai1^tm1Grid/Snai1⁺ Snai2^tm2Grid/Snai2^tm2Grid
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1^tm1Grid mutation (0 available); any Snai1 mutation (9 available)
Snai2^tm2Grid mutation (1 available); any Snai2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:121243 )

craniofacial

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• dramatic reduction in apoptotic cells is observed at intersection of palatal shelves at E14.5

cleft palate ( J:121243 )

• penetrance is 100%

digestive/alimentary system

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• dramatic reduction in apoptotic cells is observed at intersection of palatal shelves at E14.5

cleft palate ( J:121243 )

• penetrance is 100%

growth/size/body

persistence of medial edge epithelium during palatal shelf fusion ( J:121243 )

• dramatic reduction in apoptotic cells is observed at intersection of palatal shelves at E14.5

cleft palate ( J:121243 )

• penetrance is 100%

Allelic Composition	Snai2^tm2Grid/Snai2^tm2Grid Snai3^tm1.2Jhws/Snai3^tm1.2Jhws
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai2^tm2Grid mutation (1 available); any Snai2 mutation (34 available)
Snai3^tm1.2Jhws mutation (0 available); any Snai3 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:204710 )

• approximately 50% fewer homozygotes are produced than expected from heterozygote x heterozygote matings

• fewer homozygote females are produced than expected from heterozygote x heterozygote matings

premature death ( J:204710 )

• few mice survive beyond 15 weeks of age

growth/size/body

decreased body weight ( J:204710 )

• mice are approximately half the size and weight of controls

hematopoietic system

abnormal thymus cortex morphology ( J:204710 )

• altered organization of thymic cortex

abnormal thymus medulla morphology ( J:204710 )

• altered organization of thymic medulla

small thymus ( J:204710 )

• thymus is smaller than wild-type controls

thymus fibrosis ( J:204710 )

• thymus is fibrotic

abnormal thymus involution ( J:204710 )

• thymus is mostly involuted

decreased double-positive T cell number ( J:204710 )

• reduced numbers of thymic CD4+ CD8+ cells

increased neutrophil cell number ( J:204710 )

• increased neutrophil (Cd11b+ Gr1^Hi) population in bone marrow, spleen and blood

decreased B cell number ( J:204710 )

• decrease in numbers of B220+ CD19+ cells in bone marrow

• reduced numbers of B220+ CD19+ cells in the blood; phenotype is more severe in comparison to that observed in Snai3^+/-Snai2^-/- and Snai3^-/-Snai2^+/- mice

• reduced numbers of B220+ CD19+ cells in the spleen

increased single-positive T cell number ( J:204710 )

• increase in CD4+ single positive cells

increased macrophage cell number ( J:204710 )

• increased macrophage (Cd11b+ Gr1^Int) population in bone marrow and spleen

small spleen ( J:204710 )

• spleen is approximately one third the size of heterozygote controls at 4 weeks of age

disorganized spleen B cell follicle ( J:204710 )

• extensive follicle disorganization is observed in spleens from 6 week old animals

• phenotype is more severe in comparison to Snai3^+/-Snai2^-/- and Snai3^-/-Snai2^+/-

• spleen follicles are ringed with a lighter, cell deficient zone

immune system

abnormal thymus cortex morphology ( J:204710 )

• altered organization of thymic cortex

abnormal thymus medulla morphology ( J:204710 )

• altered organization of thymic medulla

small thymus ( J:204710 )

• thymus is smaller than wild-type controls

thymus fibrosis ( J:204710 )

• thymus is fibrotic

abnormal thymus involution ( J:204710 )

• thymus is mostly involuted

decreased double-positive T cell number ( J:204710 )

• reduced numbers of thymic CD4+ CD8+ cells

increased neutrophil cell number ( J:204710 )

• increased neutrophil (Cd11b+ Gr1^Hi) population in bone marrow, spleen and blood

decreased B cell number ( J:204710 )

• decrease in numbers of B220+ CD19+ cells in bone marrow

• reduced numbers of B220+ CD19+ cells in the blood; phenotype is more severe in comparison to that observed in Snai3^+/-Snai2^-/- and Snai3^-/-Snai2^+/- mice

• reduced numbers of B220+ CD19+ cells in the spleen

increased single-positive T cell number ( J:204710 )

• increase in CD4+ single positive cells

increased macrophage cell number ( J:204710 )

• increased macrophage (Cd11b+ Gr1^Int) population in bone marrow and spleen

small spleen ( J:204710 )

• spleen is approximately one third the size of heterozygote controls at 4 weeks of age

disorganized spleen B cell follicle ( J:204710 )

• extensive follicle disorganization is observed in spleens from 6 week old animals

• phenotype is more severe in comparison to Snai3^+/-Snai2^-/- and Snai3^-/-Snai2^+/-

• spleen follicles are ringed with a lighter, cell deficient zone

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:204710 )

• altered organization of thymic cortex

abnormal thymus medulla morphology ( J:204710 )

• altered organization of thymic medulla

small thymus ( J:204710 )

• thymus is smaller than wild-type controls

thymus fibrosis ( J:204710 )

• thymus is fibrotic

abnormal thymus involution ( J:204710 )

• thymus is mostly involuted

reproductive system

male infertility ( J:204710 )

• males do not produce offspring

vision/eye

abnormal eye morphology ( J:204710 )

• eye abnormalities are observed

Allelic Composition	Snai2^tm2Grid/Snai2⁺ Snai3^tm1.2Jhws/Snai3^tm1.2Jhws
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:204710 )

• altered thymic cortex organization

abnormal thymus medulla morphology ( J:204710 )

• altered thymic medulla organization

hematopoietic system

abnormal thymus cortex morphology ( J:204710 )

• altered thymic cortex organization

abnormal thymus medulla morphology ( J:204710 )

• altered thymic medulla organization

decreased B cell number ( J:204710 )

• reduced numbers of B220+ CD19+ cells in the blood

• phenotype is less severe than that observed in Snai3^-/-Snai2^-/- and Snai3^-/+Snai2^-/- mice

disorganized spleen B cell follicle ( J:204710 )

• follicle disorganization observed in spleens from 6 week old animals

• phenotype is less severe than that observed in Snai3^-/-Snai2^-/- mice

immune system

abnormal thymus cortex morphology ( J:204710 )

• altered thymic cortex organization

abnormal thymus medulla morphology ( J:204710 )

• altered thymic medulla organization

decreased B cell number ( J:204710 )

• reduced numbers of B220+ CD19+ cells in the blood

• phenotype is less severe than that observed in Snai3^-/-Snai2^-/- and Snai3^-/+Snai2^-/- mice

disorganized spleen B cell follicle ( J:204710 )

• follicle disorganization observed in spleens from 6 week old animals

• phenotype is less severe than that observed in Snai3^-/-Snai2^-/- mice

Allelic Composition	Snai2^tm2Grid/Snai2^tm2Grid Snai3^tm1.2Jhws/Snai3⁺
Genetic Background	involves: 129/Sv * 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal thymus cortex morphology ( J:204710 )

• altered thymic cortex organization

abnormal thymus medulla morphology ( J:204710 )

• altered thymic medulla organization

hematopoietic system

abnormal thymus cortex morphology ( J:204710 )

• altered thymic cortex organization

abnormal thymus medulla morphology ( J:204710 )

• altered thymic medulla organization

increased neutrophil cell number ( J:204710 )

• increase in number of neutrophils (Cd11b+ Gr1^Hi) in the blood from 6 month old mice

decreased B cell number ( J:204710 )

• reduced numbers of B220+ CD19+ cells in the blood

• phenotype is intermediate between Snai3^-/-Snai2^-/- and Snai3^-/-Snai2^+/-

increased macrophage cell number ( J:204710 )

• increase in number of macrophages (Cd11b+ Gr1^Int) in the blood from 6 month old mice

disorganized spleen B cell follicle ( J:204710 )

• follicle disorganization observed in spleens from 6 week old animals, however, phenotype is less severe than that observed in Snai3^-/-Snai2^-/- mice

immune system

abnormal thymus cortex morphology ( J:204710 )

• altered thymic cortex organization

abnormal thymus medulla morphology ( J:204710 )

• altered thymic medulla organization

increased neutrophil cell number ( J:204710 )

• increase in number of neutrophils (Cd11b+ Gr1^Hi) in the blood from 6 month old mice

decreased B cell number ( J:204710 )

• reduced numbers of B220+ CD19+ cells in the blood

• phenotype is intermediate between Snai3^-/-Snai2^-/- and Snai3^-/-Snai2^+/-

increased macrophage cell number ( J:204710 )

• increase in number of macrophages (Cd11b+ Gr1^Int) in the blood from 6 month old mice

disorganized spleen B cell follicle ( J:204710 )

• follicle disorganization observed in spleens from 6 week old animals, however, phenotype is less severe than that observed in Snai3^-/-Snai2^-/- mice

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