Mouse Genome Informatics
hm1
    Blnktm1Pjln/Blnktm1Pjln
involves: BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• 3 out of 45 animals developed solid tumors at 9 - 14 weeks of age

hematopoietic system
• 5- 10-fold reduction in number of mature B cells in spleen
• without an increase in plasma cell differentiation
• arrested B cell development at the pre-B stage
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age

immune system
• 5- 10-fold reduction in number of mature B cells in spleen
• without an increase in plasma cell differentiation
• arrested B cell development at the pre-B stage
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age


Mouse Genome Informatics
cx2
    Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y

involves: 129P2/OlaHsd * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow (J:94768)
• B cell development is completely blocked (J:94768)
• dramatic reductions of immature IgM+IgD- B cells in the bone marrow (J:94768)
• IgG3 severely reduced (J:94768)
• severely reduced (J:94768)

tumorigenesis
• increased frequency of pre-B cell lymphomas (J:94768)

hematopoietic system
• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow (J:94768)
• B cell development is completely blocked (J:94768)
• dramatic reductions of immature IgM+IgD- B cells in the bone marrow (J:94768)
• IgG3 severely reduced (J:94768)
• severely reduced (J:94768)


Mouse Genome Informatics
cx3
    Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?

involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• B cell development is partially restored, by about 4-7 fold (J:94768)
• some differentiation into mature B cells occurs (J:94768)
• recirculationg B cell population in the bone marrow is improved (J:94768)
• IgG3 levels remain severely reduced (J:94768)
• improved or restored (J:94768)

tumorigenesis
N
• tumor suppressor function is restored (J:94768)

hematopoietic system
• B cell development is partially restored, by about 4-7 fold (J:94768)
• some differentiation into mature B cells occurs (J:94768)
• recirculationg B cell population in the bone marrow is improved (J:94768)
• IgG3 levels remain severely reduced (J:94768)
• improved or restored (J:94768)


Mouse Genome Informatics
cx4
    Blnktm1Pjln/Blnktm1Pjln
Btktm1Wk/Btktm1Wk

involves: 129S4/SvJae * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• arrested B cell development at the pre-B stage (J:70406)

immune system
• arrested B cell development at the pre-B stage (J:70406)

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:70406