Mouse Genome Informatics
hm1
    Blnktm1Pjln/Blnktm1Pjln
involves: BALB/c
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• 3 out of 45 animals developed solid tumors at 9 - 14 weeks of age

hematopoietic system
• arrested B cell development at the pre-B stage
• 5- 10-fold reduction in number of mature B cells in spleen
• without an increase in plasma cell differentiation
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age

immune system
• arrested B cell development at the pre-B stage
• 5- 10-fold reduction in number of mature B cells in spleen
• without an increase in plasma cell differentiation
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age


Mouse Genome Informatics
cx2
    Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y

involves: 129P2/OlaHsd * BALB/c * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell development is completely blocked
• dramatic reductions of immature IgM+IgD- B cells in the bone marrow
• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow
• IgG3 severely reduced
• severely reduced

tumorigenesis
• increased frequency of pre-B cell lymphomas

hematopoietic system
• B cell development is completely blocked
• dramatic reductions of immature IgM+IgD- B cells in the bone marrow
• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow
• IgG3 severely reduced