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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Blnktm1Pjln
targeted mutation 1, Peter J Nielsen
MGI:2447161
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Blnktm1Pjln/Blnktm1Pjln involves: BALB/c MGI:2652495
cx2
Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:3709377
cx3
Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB MGI:3709379
cx4
Blnktm1Pjln/Blnktm1Pjln
Btktm1Wk/Btktm1Wk
involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:2652543


Genotype
MGI:2652495
hm1
Allelic
Composition
Blnktm1Pjln/Blnktm1Pjln
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 3 out of 45 animals developed solid tumors at 9 - 14 weeks of age

hematopoietic system
• arrested B cell development at the pre-B stage
• 5- 10-fold reduction in number of mature B cells in spleen
• without an increase in plasma cell differentiation
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age

immune system
• arrested B cell development at the pre-B stage
• 5- 10-fold reduction in number of mature B cells in spleen
• without an increase in plasma cell differentiation
• 3 out of 45 animals developed splenomegaly at 9 - 14 weeks of age




Genotype
MGI:3709377
cx2
Allelic
Composition
Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (58 available)
Btktm1Gsv mutation (0 available); any Btk mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell development is completely blocked
• dramatic reductions of immature IgM+IgD- B cells in the bone marrow
• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow
• IgG3 severely reduced
• severely reduced

neoplasm
• increased frequency of pre-B cell lymphomas

hematopoietic system
• B cell development is completely blocked
• dramatic reductions of immature IgM+IgD- B cells in the bone marrow
• dramatic reductions of mature IgM+IgD+ B cells in the bone marrow
• IgG3 severely reduced
• severely reduced




Genotype
MGI:3709379
cx3
Allelic
Composition
Blnktm1Pjln/Blnktm1Pjln
Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (58 available)
Btktm1Gsv mutation (0 available); any Btk mutation (10 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
• IgG3 levels remain severely reduced
• improved or restored

neoplasm
N
• tumor suppressor function is restored

hematopoietic system
• B cell development is partially restored, by about 4-7 fold
• some differentiation into mature B cells occurs
• recirculationg B cell population in the bone marrow is improved
• IgG3 levels remain severely reduced
• improved or restored




Genotype
MGI:2652543
cx4
Allelic
Composition
Blnktm1Pjln/Blnktm1Pjln
Btktm1Wk/Btktm1Wk
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Pjln mutation (0 available); any Blnk mutation (58 available)
Btktm1Wk mutation (1 available); any Btk mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• arrested B cell development at the pre-B stage

immune system
• arrested B cell development at the pre-B stage

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:70406





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory