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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Prnp)a20Cwe
transgene insertion a20, Charles Weissmann
MGI:2447133
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cxcr5tm1.1Namt/Cxcr5tm1.1Namt
Tg(Itgax-cre)1-1Reiz/0
Tg(Prnp)a20Cwe/0 		involves: C57BL/6 * C57BL/6J * CBA MGI:5903129
cx2
 		Prnptm2Edin/Prnptm2Edin
Tg(Prnp)a20Cwe/0 		B6.Cg-Prnptm2Edin Tg(Prnp)a20Cwe MGI:4821388
cx3
 		Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)a20Cwe/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:4821386
cx4
 		Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)a20Cwe/0 		Not Specified MGI:3531092
tg5
 		Tg(Prnp)a20Cwe/0 Not Specified MGI:4821384


Genotype
MGI:5903129
cn1
Allelic
Composition		 Cxcr5tm1.1Namt/Cxcr5tm1.1Namt
Tg(Itgax-cre)1-1Reiz/0
Tg(Prnp)a20Cwe/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr5tm1.1Namt mutation (0 available); any Cxcr5 mutation (25 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:241561 )
• following oral administration of scrapie prion proteins, mice exhibit reduced follicular cell-associated prion infectivity in the spleen compared with control mice
• however, accumulation of prions in medial lymph nodes is normal




Genotype
MGI:4821388
cx2
Allelic
Composition		 Prnptm2Edin/Prnptm2Edin
Tg(Prnp)a20Cwe/0
Genetic
Background		 B6.Cg-Prnptm2Edin Tg(Prnp)a20Cwe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (150 available)
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:107170 )
• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells

cellular
abnormal neuronal precursor proliferation ( J:107170 )
• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells




Genotype
MGI:4821386
cx3
Allelic
Composition		 Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)a20Cwe/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (39 available); any Prnp mutation (150 available)
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:129512 )
• mice exhibit a reduction in thymocyte numbers compared with wild-type mice
• however, supplementation with copper partially reverses lowered thymocyte numbers
abnormal T cell differentiation ( J:129512 )
• gammadelta T cell differentiation is promoted while alphabeta T cell differentiation is impaired compared to in wild-type mice
• T cell differentiation is partially arrested at DN3 unlike in wild-type mice
• however, supplementation with copper partially reverses defects in T cell differentiation
increased double-negative T cell number ( J:129512 )
• partially reversed by copper supplementation
decreased double-positive T cell number ( J:129512 )
• partially reversed by copper supplementation
increased gamma-delta T cell number ( J:129512 )
• 9-fold, partially reversed by copper supplementation
abnormal B cell morphology ( J:129512 )
• the proportion of CD19+ and B220+ B cells is increased compared to in wild-type mice
• however, the total number of B cells is normal

homeostasis/metabolism
abnormal copper level ( J:129512 )
• copper levels in the brain and thymus are increased compared to in wild-type mice
increased brain copper level ( J:126728 )
• after 12 months, mice exhibit increased brain copper levels compared with wild-type mice
• copper levels in the synaptosomes are increased compared to in wild-type mice
abnormal magnesium ion homeostasis ( J:126728 )
• mice exhibit an increase in brain magnesium level compared with wild-type mice

hematopoietic system
decreased thymocyte number ( J:129512 )
• mice exhibit a reduction in thymocyte numbers compared with wild-type mice
• however, supplementation with copper partially reverses lowered thymocyte numbers
abnormal T cell differentiation ( J:129512 )
• gammadelta T cell differentiation is promoted while alphabeta T cell differentiation is impaired compared to in wild-type mice
• T cell differentiation is partially arrested at DN3 unlike in wild-type mice
• however, supplementation with copper partially reverses defects in T cell differentiation
increased double-negative T cell number ( J:129512 )
• partially reversed by copper supplementation
decreased double-positive T cell number ( J:129512 )
• partially reversed by copper supplementation
increased gamma-delta T cell number ( J:129512 )
• 9-fold, partially reversed by copper supplementation
abnormal B cell morphology ( J:129512 )
• the proportion of CD19+ and B220+ B cells is increased compared to in wild-type mice
• however, the total number of B cells is normal

nervous system
increased brain copper level ( J:126728 )
• after 12 months, mice exhibit increased brain copper levels compared with wild-type mice
• copper levels in the synaptosomes are increased compared to in wild-type mice

endocrine/exocrine glands
decreased thymocyte number ( J:129512 )
• mice exhibit a reduction in thymocyte numbers compared with wild-type mice
• however, supplementation with copper partially reverses lowered thymocyte numbers




Genotype
MGI:3531092
cx4
Allelic
Composition		 Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)a20Cwe/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Cwe mutation (39 available); any Prnp mutation (150 available)
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to prion infection ( J:32214 )
• scrapie-innoculated transgenic mice displayed typical scrapie symptoms, such as hind limb paresis, foot clasp reflex, kyphosis, ataxia, disorientation and minced gait
• incubation times to occurrence of first symptoms as well as the terminal state were shorter than wild-type control group




Genotype
MGI:4821384
tg5
Allelic
Composition		 Tg(Prnp)a20Cwe/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to prion infection ( J:130657 , J:143528 )
• following inoculation with RML scrapie prion, mice exhibit more rapid scrapie development and spread with axonal degeneration compared with similarly treated wild-type mice (J:130657)
• mice inoculated with mouse-adapted Rocky Mountain Laboratory prions develop scrapie after 74 +/- 6 days compared to wild-type mice that develop scrapie after 170 +/- 12 days (J:143528)

nervous system
axon degeneration ( J:130657 )
• following inoculation with RML scrapie prion




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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory