About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ltb/Tnf/Ltatm1Dvk
targeted mutation 1, Dmitry V Kuprash
MGI:2446567
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk B6.Cg-Ltb/Tnf/Ltatm1Dvk MGI:4440881
hm2
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk involves: C57BL/6 MGI:3652521
cx3
Mertknmf12/Mertknmf12
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
involves: C57BL/6J MGI:5287882


Genotype
MGI:4440881
hm1
Allelic
Composition
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic
Background
B6.Cg-Ltb/Tnf/Ltatm1Dvk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching (J:80616)
• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching (J:80616)
• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity (J:80616)
• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity (J:80616)
• spleen architecture is severely disturbed (J:80616)
• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles (J:80616)
• spleen architecture is severely disturbed (J:80616)
• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles (J:80616)
• absence of polarized B-cell follicles (J:80616)
• absence of polarized B-cell follicles (J:80616)
• do not form germinal centers (J:80616)
• do not form germinal centers (J:80616)
• gradual reduction of white pulp size (J:80616)
• gradual reduction of white pulp size (J:80616)
• specific IgG antibodies are almost undetectable in SRBC immunized mutants (J:80616)
• specific IgG antibodies are almost undetectable in SRBC immunized mutants (J:80616)
• increased susceptibility to Listeria monocytogenes infections, with mutants dying by day 8 while wild-type mice survive (J:80616)
• increased susceptibility to Salmonella enterica infection (J:80616)
• increased susceptibility to Listeria monocytogenes infections, with mutants dying by day 8 while wild-type mice survive (J:80616)
• increased susceptibility to Salmonella enterica infection (J:80616)

hematopoietic system
• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching (J:80616)
• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching (J:80616)
• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity (J:80616)
• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity (J:80616)
• spleen architecture is severely disturbed (J:80616)
• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles (J:80616)
• spleen architecture is severely disturbed (J:80616)
• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles (J:80616)
• absence of polarized B-cell follicles (J:80616)
• absence of polarized B-cell follicles (J:80616)
• do not form germinal centers (J:80616)
• do not form germinal centers (J:80616)
• gradual reduction of white pulp size (J:80616)
• gradual reduction of white pulp size (J:80616)
• specific IgG antibodies are almost undetectable in SRBC immunized mutants (J:80616)
• specific IgG antibodies are almost undetectable in SRBC immunized mutants (J:80616)




Genotype
MGI:3652521
hm2
Allelic
Composition
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts (J:109621)
• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts (J:109621)

immune system
• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts (J:109621)
• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts (J:109621)




Genotype
MGI:5287882
cx3
Allelic
Composition
Mertknmf12/Mertknmf12
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Tnf mutation (20 available)
Mertknmf12 mutation (1 available); any Mertk mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at P45 abnormalities are seen across the entire retina (J:175587)
• at P45 abnormalities are seen across the entire retina (J:175587)
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone (J:175587)
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone (J:175587)
• in the peripheral retina at 3 months of age (J:175587)
• in the peripheral retina at 3 months of age (J:175587)
• markedly thinned across the entire retina at 3 months of age (J:175587)
• markedly thinned across the entire retina at 3 months of age (J:175587)

nervous system
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone (J:175587)
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone (J:175587)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory