Mouse Genome Informatics
hm1
    Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
B6.Cg-Ltb/Tnf/Ltatm1Dvk
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity
• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching
• spleen architecture is severely disturbed
• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles
• absence of polarized B-cell follicles
• do not form germinal centers
• gradual reduction of white pulp size
• specific IgG antibodies are almost undetectable in SRBC immunized mutants
• increased susceptibility to Listeria monocytogenes infections, with mutants dying by day 8 while wild-type mice survive
• increased susceptibility to Salmonella enterica infection

hematopoietic system
• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity
• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching
• spleen architecture is severely disturbed
• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles
• absence of polarized B-cell follicles
• do not form germinal centers
• gradual reduction of white pulp size
• specific IgG antibodies are almost undetectable in SRBC immunized mutants


Mouse Genome Informatics
hm2
    Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts

immune system
• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts


Mouse Genome Informatics
cx3
    Mertknmf12/Mertknmf12
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk

involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
• at P45 abnormalities are seen across the entire retina
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone
• in the peripheral retina at 3 months of age
• markedly thinned across the entire retina at 3 months of age

nervous system
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone