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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ltb/Tnf/Ltatm1Dvk
targeted mutation 1, Dmitry V Kuprash
MGI:2446567
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk B6.Cg-Ltb/Tnf/Ltatm1Dvk MGI:4440881
hm2
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk involves: C57BL/6 MGI:3652521
cx3
Mertknmf12/Mertknmf12
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
involves: C57BL/6J MGI:5287882


Genotype
MGI:4440881
hm1
Allelic
Composition
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic
Background
B6.Cg-Ltb/Tnf/Ltatm1Dvk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Tnf mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching
• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity
• spleen architecture is severely disturbed
• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles
• absence of polarized B-cell follicles
• do not form germinal centers
• gradual reduction of white pulp size
• specific IgG antibodies are almost undetectable in SRBC immunized mutants
• increased susceptibility to Listeria monocytogenes infections, with mutants dying by day 8 while wild-type mice survive
• increased susceptibility to Salmonella enterica infection

hematopoietic system
• specific IgG antibodies are almost undetectable in SRBC immunized mutants, indicating defective class switching
• 2-3 fold increase in the number of leukocytes in the spleen, blood, and peritoneal cavity
• spleen architecture is severely disturbed
• distribution of lymphocytes and their functional compartmentalization are severely disorganized in the spleen, with IgD+ B cells scattered along red and white pulp and T cells mostly condensed around central arterioles
• absence of polarized B-cell follicles
• do not form germinal centers
• gradual reduction of white pulp size
• specific IgG antibodies are almost undetectable in SRBC immunized mutants




Genotype
MGI:3652521
hm2
Allelic
Composition
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Tnf mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts

immune system
• percentage of splenic white pulp is lower than in wild-type, Ltb, the two Lta mutant lines, Ltb or Ltbr knockouts




Genotype
MGI:5287882
cx3
Allelic
Composition
Mertknmf12/Mertknmf12
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnf/Ltatm1Dvk mutation (1 available); any Tnf mutation (26 available)
Mertknmf12 mutation (1 available); any Mertk mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at P45 abnormalities are seen across the entire retina
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone
• in the peripheral retina at 3 months of age
• markedly thinned across the entire retina at 3 months of age

nervous system
• accelerated degeneration compared to mice homozygous for the Mertk mutation alone





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory