About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ltb/Tnftm1.1Dvk
targeted mutation 1.1, Dmitry V Kuprash
MGI:2446565
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 MGI:3768333


Genotype
MGI:3768333
hm1
Allelic
Composition
Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb/Tnftm1.1Dvk mutation (1 available); any Tnf mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• germinal centers do not form in the spleen
• spleen architecture is more disrupted than in Ltbtm1Kpf homozygotes
• the marginal zone in the spleen is absent and T and B cell areas are variable
• mature follicular dendritic cells are absent from the mesenteric lymph nodes
• in most mice only one large spherical mesenteric lymph node is present unlike in wild-type mice that possess a chain of three elongated lymph node segments
• mature follicular dendritic cells are absent from the mesenteric lymph nodes
• unlike in Ltbtm1Kpf homozygotes and wild-type mice, PNA+ B cells do not aggregate but remain scattered
• the reticulum of the deep cortex is uniform and coarser than in wild-type mice and there is no transition to germinal center-like structures
• cervical lymph nodes could not be identified
• mice lack brachial, iliac, axillary, inguinal and popliteal lymph nodes
• however, mesenteric and sacral lymph nodes are present

hematopoietic system
• germinal centers do not form in the spleen
• spleen architecture is more disrupted than in Ltbtm1Kpf homozygotes
• the marginal zone in the spleen is absent and T and B cell areas are variable





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory