Mouse Genome Informatics
hm1
    Ltb/Tnftm1.1Dvk/Ltb/Tnftm1.1Dvk
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• germinal centers do not form in the spleen
• spleen architecture is more disrupted than in Ltbtm1Kpf homozygotes
• the marginal zone in the spleen is absent and T and B cell areas are variable
• mature follicular dendritic cells are absent from the mesenteric lymph nodes
• in most mice only one large spherical mesenteric lymph node is present unlike in wild-type mice that possess a chain of three elongated lymph node segments
• mature follicular dendritic cells are absent from the mesenteric lymph nodes
• unlike in Ltbtm1Kpf homozygotes and wild-type mice, PNA+ B cells do not aggregate but remain scattered
• the reticulum of the deep cortex is uniform and coarser than in wild-type mice and there is no transition to germinal center-like structures
• cervical lymph nodes could not be identified
• mice lack brachial, iliac, axillary, inguinal and popliteal lymph nodes
• however, mesenteric and sacral lymph nodes are present

hematopoietic system
• germinal centers do not form in the spleen
• spleen architecture is more disrupted than in Ltbtm1Kpf homozygotes
• the marginal zone in the spleen is absent and T and B cell areas are variable