Phenotypes associated with this allele

• Allele Symbol: Icos^tm1Mak
• Allele Name: targeted mutation 1, Tak Mak
• Allele ID: MGI:2445839
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Icos^tm1Mak/Icos^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:2672936

Genotype
MGI:2672936

hm1

• Allelic Composition: Icos^tm1Mak/Icos^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell number ( J:155586 )

• drastic reduction in the percentage of germinal B cells relative to the total number of B cells

decreased CD4-positive, alpha-beta T cell number ( J:155586 )

• percentage of TFH (CXCR5+, ICOS+) cells reduced in the Peyer's patch and spleen

abnormal spleen morphology ( J:66702 )

decreased spleen germinal center number ( J:66702 , J:155586 )

• the mean number of germinal centers is severely reduced (J:66702)

• decreased number of germinal center B cells and germinal center foci (J:155586)

decreased spleen germinal center size ( J:66702 )

• the size of the germinal centers is severely reduced

abnormal Peyer's patch germinal center morphology ( J:155586 )

• the germinal center area is greatly reduced

small Peyer's patches ( J:155586 )

• total cellularity of Peyer's Patches is substantially reduced

abnormal immune system physiology ( J:66702 )

• interactions between T and B cells were impaired

abnormal B cell physiology ( J:66702 )

• B cell proliferation normal

• no impairment in T-cell independent response and B cell development was normal

abnormal class switch recombination ( J:66702 )

• B cell isotype switching was impaired in both primary and secondary T-cell dependent B cell response

decreased IgA level ( J:155586 )

• content of secreted IgA in the feces is dramatically reduced

• but serum IgA is normal

decreased IgE level ( J:66702 )

• after stimulation with T-cell dependent antigen

decreased IgG1 level ( J:66702 , J:155586 )

• IgG1 only immunoglobulin significantly reduced in amount (J:66702)

decreased IgG2b level ( J:155586 )

decreased IgG2c level ( J:155586 )

abnormal T cell physiology ( J:66702 )

• fewer T cells producing IL4

• IFN-gamma production unaffected

decreased T cell proliferation ( J:66702 )

• impaired early stage T-cell proliferation to some stimuli

• however, T cell development was unaffected

decreased interleukin-21 secretion ( J:155586 )

• expression analysis of CD4 T-cells shows decreased IL-21 in response to secondary activation

hematopoietic system

abnormal B cell number ( J:155586 )

• drastic reduction in the percentage of germinal B cells relative to the total number of B cells

decreased CD4-positive, alpha-beta T cell number ( J:155586 )

• percentage of TFH (CXCR5+, ICOS+) cells reduced in the Peyer's patch and spleen

abnormal spleen morphology ( J:66702 )

decreased spleen germinal center number ( J:66702 , J:155586 )

• the mean number of germinal centers is severely reduced (J:66702)

• decreased number of germinal center B cells and germinal center foci (J:155586)

decreased spleen germinal center size ( J:66702 )

• the size of the germinal centers is severely reduced

abnormal B cell physiology ( J:66702 )

• B cell proliferation normal

• no impairment in T-cell independent response and B cell development was normal

abnormal class switch recombination ( J:66702 )

• B cell isotype switching was impaired in both primary and secondary T-cell dependent B cell response

decreased IgA level ( J:155586 )

• content of secreted IgA in the feces is dramatically reduced

• but serum IgA is normal

decreased IgE level ( J:66702 )

• after stimulation with T-cell dependent antigen

decreased IgG1 level ( J:66702 , J:155586 )

• IgG1 only immunoglobulin significantly reduced in amount (J:66702)

decreased IgG2b level ( J:155586 )

decreased IgG2c level ( J:155586 )

abnormal T cell physiology ( J:66702 )

• fewer T cells producing IL4

• IFN-gamma production unaffected

decreased T cell proliferation ( J:66702 )

• impaired early stage T-cell proliferation to some stimuli

• however, T cell development was unaffected

cellular

decreased T cell proliferation ( J:66702 )

• impaired early stage T-cell proliferation to some stimuli

• however, T cell development was unaffected