All Phenotypes Cer1<tm1Belo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cer1^tm1Belo/Cer1^tm1Belo	either: 129X1/SvJ-Cer1^tm1Belo or (involves: 129X1/SvJ * C57BL/6)	MGI:3723107
hm2	Cer1^tm1Belo/Cer1^tm1Belo	involves: 129X1/SvJ	MGI:3723134
cx3	Cer1^tm1Belo/Cer1^tm1Belo Nog^tm1Amc/Nog^tm1Amc	involves: 129S1/Sv * 129X1/SvJ	MGI:3723131
cx4	Cer1^tm1Belo/Cer1^tm1Belo Cripto^tm1Eda/Cripto^tm1Eda	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3851256
cx5	Cer1^tm1Belo/Cer1^tm1Belo Shisa2^tm1Sia/Shisa2^tm1Sia	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3718479

Allelic Composition	Cer1^tm1Belo/Cer1^tm1Belo
Genetic Background	either: 129X1/SvJ-Cer1^tm1Belo or (involves: 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cer1^tm1Belo mutation (0 available); any Cer1 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:62082 )

• homozygotes are healthy and fertile and show no anterior patterning defects

Allelic Composition	Cer1^tm1Belo/Cer1^tm1Belo
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cer1^tm1Belo mutation (0 available); any Cer1 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:74136 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:74136 )

• double homozygotes exhibit the same abnormalities as single homozygous Nog mutants

nervous system

abnormal neural tube closure ( J:74136 )

• abnormalities is neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon

open neural tube ( J:74136 )

exencephaly ( J:74136 )

• in mutants where the frontal, parietal and interparietal bones are absent, the brain is exposed at birth

skeleton

abnormal basicranium morphology ( J:74136 )

• fusion of presphenoid, basisphenoid, and basioccipital bones

abnormal frontal bone morphology ( J:74136 )

• frontal bone is loose or absent

abnormal interparietal bone morphology ( J:74136 )

• interparietal bones are loose or absent

abnormal occipital bone morphology ( J:74136 )

• occipital condyles are loose, showing variability in the distance separating them

abnormal parietal bone morphology ( J:74136 )

• parietal bone is loose or absent

limbs/digits/tail

short limbs ( J:74136 )

• truncated limbs

absent tail ( J:74136 )

craniofacial

abnormal basicranium morphology ( J:74136 )

• fusion of presphenoid, basisphenoid, and basioccipital bones

abnormal frontal bone morphology ( J:74136 )

• frontal bone is loose or absent

abnormal interparietal bone morphology ( J:74136 )

• interparietal bones are loose or absent

abnormal occipital bone morphology ( J:74136 )

• occipital condyles are loose, showing variability in the distance separating them

abnormal parietal bone morphology ( J:74136 )

• parietal bone is loose or absent

embryo

abnormal neural tube closure ( J:74136 )

• abnormalities is neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon

open neural tube ( J:74136 )

Allelic Composition	Cer1^tm1Belo/Cer1^tm1Belo Cripto^tm1Eda/Cripto^tm1Eda
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cer1^tm1Belo mutation (0 available); any Cer1 mutation (11 available)
Cripto^tm1Eda mutation (1 available); any Cripto mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:132584 )

N	• well developed embyonic region at E9.5 • migration of anterior visceral endoderm is rescued

abnormal rostral-caudal axis patterning ( J:132584 )

• anterior-posterior axis has developed by E6.5

• delayed at E9.5 relative to controls (equivalent to E8)

• well developed anterior-posterior axis at E8

nervous system

nervous system phenotype ( J:132584 )

N	• posterior neuroectoderm is present at E12.5

cardiovascular system

cardiovascular system phenotype ( J:132584 )

N	• developing heart is present at E12.5

Allelic Composition	Cer1^tm1Belo/Cer1^tm1Belo Shisa2^tm1Sia/Shisa2^tm1Sia
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cer1^tm1Belo mutation (0 available); any Cer1 mutation (11 available)
Shisa2^tm1Sia mutation (0 available); any Shisa2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:122557 )

N	• no defects in anterior neuroectoderm development are detected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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